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Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts
Julie Elisabeth Oomens, Justine E. F. Moonen, Stephanie J. B. Vos, Magdalena Beran, Pedro Mateus, Peter Paul De Deyn, Wiesje M. van der Flier, Mirjam I. Geerlings et al.. BMC Neurology, 2025-02-12
Topic: Risk, prevention and care in population studies
Plain-language summary
We increased the findability, accessibility, interoperability and reusability (FAIR) status of the cohorts through harmonization of data across cohorts, implementation of medical imaging repositories for scan management, implementation of the Personal Health Train infrastructure and provision of meta-data in existing cohort catalogues. We established the ethical and legal frameworks required for federated and pooled analyses and performed the first remote federated data analyses using the Personal Health Train infrastructure. To determine biomarkers of Alzheimer's disease, endothelial dysfunction and inflammation, 2554 plasma samples were analyzed centrally. Federated, pooled, and coordinated meta-analyses have led to multiple publications in the context of NCDC. The combination of population-based and clinical cohorts, the coordinated assessment of plasma markers in previously collected samples and implementation and use of the Personal Health Train infrastructure for federated analysis are both feasible and promising for future collaborative efforts.
What this study adds
Evidence grade: High
This is a pooled review. This consortium harmonized data across Dutch dementia cohorts and carried out federated analyses, including central analysis of plasma samples for biomarkers of Alzheimer's disease, endothelial dysfunction and inflammation. It shows that this collaborative infrastructure is feasible and promising for future research, but reports no treatment or prevention outcome.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Oomens, J. E., Moonen, J. E. F., Vos, S. J. B., Beran, M., Mateus, P., De Deyn, P. P., et al. (2025). Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts. BMC Neurology. https://doi.org/10.1186/s12883-024-03995-4
Vancouver
Oomens JE, Moonen JEF, Vos SJB, Beran M, Mateus P, De Deyn PP, et al. Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts. BMC Neurology. 2025. doi:10.1186/s12883-024-03995-4. PMID: 39939930.
BibTeX
@article{oomens2025-39939930,
author = {Oomens, Julie Elisabeth and Moonen, Justine E. F. and Vos, Stephanie J. B. and Beran, Magdalena and Mateus, Pedro and De Deyn, Peter Paul and van der Flier, Wiesje M. and Geerlings, Mirjam I. and others},
title = {{Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts}},
journal = {BMC Neurology},
year = {2025},
doi = {10.1186/s12883-024-03995-4},
pmid = {39939930},
url = {https://doi.org/10.1186/s12883-024-03995-4}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We increased the findability, accessibility, interoperability and reusability (FAIR) status of the cohorts through harmonization of data across cohorts, implementation of medical imaging repositories for scan management, implementation of the Personal Health Train infrastructure and provision of meta-data in existing cohort catalogues.
- We established the ethical and legal frameworks required for federated and pooled analyses and performed the first remote federated data analyses using the Personal Health Train infrastructure.
- To determine biomarkers of Alzheimer's disease, endothelial dysfunction and inflammation, 2554 plasma samples were analyzed centrally.
- Federated, pooled, and coordinated meta-analyses have led to multiple publications in the context of NCDC.
- The combination of population-based and clinical cohorts, the coordinated assessment of plasma markers in previously collected samples and implementation and use of the Personal Health Train infrastructure for federated analysis are both feasible and promising for future collaborative efforts.
Why it matters
This consortium harmonized data across Dutch dementia cohorts and carried out federated analyses, including central analysis of plasma samples for biomarkers of Alzheimer's disease, endothelial dysfunction and inflammation. It shows that this collaborative infrastructure is feasible and promising for future research, but reports no treatment or prevention outcome.
New to this subject? Start with our plain-English guide: Alzheimer's in numbers →
Study details
- Study designmeta-analysis
- Evidence strengthHigh
How this study scored 54/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMC Neurology) |
| Journal's citation record | 1 / 4 | BMC Neurology: journal h-index 122 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Pieter Jelle Visser: h-index 90 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 24 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39939930) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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