Newest studies

Co-designing a model of palliative care for people with advanced dementia

33/100 ✓ Peer-reviewed End-of-life care International Journal of Integrated Care

Key finding: These inputs and activities were shown in the logic model to result in short, medium, and long-term outcomes, including reduced healthcare resource use and increased quality of life for people with dementia at the end of life. +1 more finding

• End-of-Life Care

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The meaning of “total pain” in the context of living and dying with dementia

33/100 ✓ Peer-reviewed End-of-life care Frontiers in Sociology

Key finding: A balanced understanding of dementia’s impact (acknowledging both continuity and loss, alternatives and socially constructed aspects) better reflects the realities of dementia and creates new possibilities for supportive care practices to improve pain management and quality of life. +4 more findings

• End-of-Life Care

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Medical decision-making experiences of persons with dementia and their carepartners: a qualitative study

44/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: We interviewed 30 participants (9 PWD, 21 carepartners). +3 more findings

• End-of-Life Care

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Caregiver burden in mild cognitive impairment due to Alzheimer's disease—a longitudinal study

39/100 ✓ Peer-reviewed Mild cognitive impairment Psychogeriatrics

Key finding: At baseline, the mean ZBI score was 24.5 ± 15.2 and correlated positively with caregiver CES-D and STAI scores and with patient neuropsychiatric symptoms (NPI-frequency × severity) and distress felt by the caregiver (NPI-distress). +3 more findings

• Early Stage
• Caregiving

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Mapping knowledge landscapes and emerging trends in digital biomarkers for dementia in older adults: A scoping and bibliometric analysis

38/100 ✓ Peer-reviewed Digital health tools Archives of Gerontology and Geriatrics Plus

Key finding: The results reveal growing contributions from global regions, particularly the U.S., Italy, and China, with increasing emphasis on assistive technologies and artificial intelligence for early diagnosis. +1 more finding

• Digital Tools

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Cochlear Implantation Is Associated With Reduced Incidence of Dementia in Severe Hearing Loss

39/100 ✓ Peer-reviewed How common it is Ear and Hearing

Key finding: The study involved 649 individuals in the CI group, 35,076 in the HA, 16,494 in the NR, and 1,280,788 in the NHL group. +4 more findings

• Risk Factors

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Amyloid and Tau Pathology in Cognitively Unimpaired Individuals With a Parental History of Alzheimer Disease

58/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: (69.4% female) were aged 68.3 ± 5.1 years at their first PET scans. +4 more findings

• Brain Scans
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans

62/100 ✓ Peer-reviewed Laboratory science Nature Communications

Key finding: Putative glymphatic influx, evaluated using intravenous contrast-enhanced dynamic T1 mapping, increases significantly at the putamen after 12 weeks of long-term exercise using a cycle ergometer. +3 more findings

• Brain Biology
• Lifestyle

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Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease

59/100 ✓ Peer-reviewed Laboratory science Nature

Key finding: Single-nucleus RNA sequencing revealed a subpopulation of MGnD microglia in Havcr2-deficient 5×FAD mice characterized by increased pro-phagocytic and anti-inflammatory gene expression alongside reduced pro-inflammatory gene expression. +1 more finding

• Brain Biology

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Bilingualism and "brain reserve" in subregions of the hippocampal formation

55/100 ✓ Peer-reviewed Risk factors GeroScience

Key finding: With aging, the hippocampal formation shows variable structural atrophy, which is associated with a decline in cognitive performance. +4 more findings

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Membrane Charge Drives the Aggregation of TDP-43 Pathological Fragments

45/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the American Chemical Society

Key finding: Our results show that lipid charge affects the modality by which M85 interacts with membranes: a higher negative charge induces the protein to bind to the bilayer surface, promoting protein aggregation and decreasing lipid bilayer damage that this interaction causes.

• Brain Biology

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Financial Toxicity in Dementia Caregiving: Sociodemographic Predictors in a U.S. Nationally Representative Survey

42/100 ✓ Peer-reviewed Disparities The Gerontologist

Key finding: 52.7% of dementia caregivers in the United States experience financial toxicity. +4 more findings

• Side Effects
• Caregiving

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Pain Assessment and Management in Dementia Care: Qualitative Perspectives of People With Dementia, Their Families, and Healthcare Professionals

43/100 ✓ Peer-reviewed Caregiving Journal of Clinical Nursing

Key finding: Four main themes and 10 subthemes were identified. +4 more findings

• Caregiving

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AI-Driven Alzheimer’s Detection Performance Analysis of Pretrained CNN Models on MRI Data

31/100 ✓ Peer-reviewed Brain scans and imaging International Journal for Research in Applied Science and Engineering Technology

Key finding: We trained and compared six pre-trained Convolutional Neural Network (CNN) models—VGG19, ResNet101, EfficientNetB3, MobileNetV2, InceptionV3, and DenseNet121—to differentiate MRI scans as Alzheimer and Non-Alzheimer. +4 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes

62/100 ✓ Peer-reviewed Prevention and risk Nature Medicine

Key finding: Recent research revealed pathophysiological heterogeneity and distinct subgroups in both T2D and prediabetes, prompting exploration of personalized risk factors. +3 more findings

• Lifestyle

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Nature-based Solutions as Building Blocks for coastal flood risk reduction: a model-based ecosystem service assessment

46/100 ✓ Peer-reviewed Prevention and risk Scientific Reports

Key finding: While already challenging for present-day evaluations, this limitation becomes even more significant when addressing future climate scenarios, introducing deep uncertainties in the evaluation. +2 more findings

• Prevention

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Lecanemab en la enfermedad de Alzheimer

30/100 ✓ Peer-reviewed Treatments Acta neurológica colombiana

Key finding: En el estudio se inscribieron 1795 participantes, de los cuales 898 fueron asignados para recibir lecanemab y 897 para placebo. +4 more findings

• Treatments

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Incidence of Frailty, Dementia, and Disability Among Community‐Living Older Americans According to County‐Level Disadvantage

56/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: Totally 7499 participants were included in the analysis, representing 40,728,543 community-living older Americans. +4 more findings

• Risk Factors

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SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

43/100 ✓ Peer-reviewed Disease mechanisms Cell reports

Key finding: We previously showed that SFRP1, a glial-derived protein elevated in AD brains from preclinical stages, contributes to disease progression, implicating glial factors in early pathogenesis. +1 more finding

• Brain Biology

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NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies

43/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in immunology

Key finding: The NLRP3 inflammasome, a key mediator of neuroinflammation, has emerged as a critical player in AD pathogenesis, contributing to the accumulation of β-amyloid (Aβ) plaques, tau hyperphosphorylation, and neuronal damage. +4 more findings

• Brain Biology
• Treatments

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The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis

88/100 ✓ Peer-reviewed Drug development BMC medicine

Key finding: Our analysis encompassed 22 RCTs involving 138,282 participants (mean age 64.8 years, 36.4% female). +4 more findings

• Treatments

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Unraveling the Link Between Bullous Pemphigoid and Neurological Disease: A Single-center Study of 257 Patients

33/100 ✓ Peer-reviewed Inflammation and the immune system Actas dermo-sifiliograficas

Key finding: Our case series highlighted the relevance of neurological comorbidities in BP patients; although the pathogenesis is still to be elucidated, the neuroinflammation present in neurodegenerative diseases could explain the neurocutaneous link and the chronological relationship between these entities. +2 more findings

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Rate of advance care planning practice during the COVID-19 outbreak in Japan: a cross-sectional survey study

44/100 ✓ Peer-reviewed End-of-life care Aging Clinical and Experimental Research

Key finding: Of the 258 surveyed doctors, 74 (28.7%) practiced ACP. +4 more findings

• End-of-Life Care

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Unmet Palliative Care Needs Among Patients with Dementia at the End of Life and Frequent Use of the Emergency Department: One-Year Retrospective Study in a Central Hospital

44/100 ✓ Peer-reviewed End-of-life care Journal of Palliative Medicine

Key finding: Unmet PC needs were highly prevalent (78.2%). +3 more findings

• End-of-Life Care
• Care Services

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Relationship Between Perceived and Objective Financial Abilities Among Older Adults: Results From the Advanced Cognitive Training for Independent and Vital Elderly Cohort

46/100 ✓ Peer-reviewed Prevention trials The Gerontologist

Key finding: In years when older adults subjectively reported fewer difficulties with their finances, they objectively performed better at financial tasks and this relationship became stronger over 10 years. +4 more findings

Full summary, score breakdown and related studies → Original source