Newest studies

Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology

58/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: These findings suggest EPVS burden to be a potential marker of both CSVD and AD-related BBM pathology. +2 more findings

• Biomarkers
• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies

70/100 ✓ Peer-reviewed Biomarkers Movement disorders : official journal of the Movement Disorder Society

Key finding: A total of 143 iRBD participants (110 male, 67.7 ± 8.0 years) were included. +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults

52/100 ✓ Peer-reviewed Vascular contributions Age and Ageing

Key finding: This study included 3540 participants with RVC data and 489 with WMH data (median [IQR] age: 73.2 [71.4-76.3] and 72.5 [71.2-75.4] years; female: 52.9% and 47.6%) over a median follow-up of 7.4 [IQR 5.5-8.5] and 3.8 [IQR 2.9-5.3] years, respectively. +4 more findings

Full summary, score breakdown and related studies → Original source

An exploratory study of the diffusion tensor imaging analysis along perivascular spaces (DTI-ALPS) index combined with quantitative analysis of choroid plexus volume and perivascular spaces in different cognitive stages of cerebral small vessel disease

36/100 ✓ Peer-reviewed Vascular contributions Quantitative Imaging in Medicine and Surgery

Key finding: NCs/CSVD-CN: AUC =0.900, 95% CI: 0.847-0.952. +1 more finding

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates

41/100 ✓ Peer-reviewed Vascular contributions European journal of medical research

Key finding: Neuropsychological assessments indicated that the CSVD group scored significantly lower than the HC group in general cognitive level, memory, visuospatial ability, executive function, and language function (p < 0.05). 2. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Acceptability of Euthanasia for People With Dementia: Perspectives of Clinicians From Six Countries

52/100 ✓ Peer-reviewed End-of-life care American Journal of Geriatric Psychiatry

Key finding: Participants included 202 physicians and three nurse specialists who assumed similar medical responsibilities. +4 more findings

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Advance care planning with people living with dementia: ethical considerations of physicians in the United States and the Netherlands

42/100 ✓ Peer-reviewed End-of-life care The Journals of Gerontology Series B

Key finding: Interviews with 50 Dutch physicians and 47 American physicians and 3 nurse practitioners generated three themes of ethical considerations: (1) Respecting the autonomy of the person with dementia, (2) Rationality as the basis for decisions and subsequent actions, and (3) Minimizing burden and suffering. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Apolipoprotein E, Executive Function, and Falls across Cognitive Status: A Cross-Sectional Study

44/100 ✓ Peer-reviewed Clinical safety Dementia and Geriatric Cognitive Disorders

Key finding: ApoE4 did not moderate the EF and falls relationship (p ≥ 0.05). +4 more findings

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2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

32/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Pharmacology

Key finding: 2′-FL improved cognitive performance in 5xFAD mice, reduced Aβ plaque deposition and pro-inflammatory cytokine levels in vivo , and mitigated oxidative stress and synaptic dysfunction in cellular models. +3 more findings

• Brain Biology

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CSF markers of neuroinflammation, synaptic dysfunction and [18F]DOPA-PET in Parkinson's disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Parkinsonism & Related Disorders

Key finding: In PD patients, a decrease in [ 18 F]DOPA PET retention correlated with disease duration as well as CSF neurodegenerative and synaptic biomarkers but not with inflammatory biomarkers or [ 18 F]RO948 PET midbrain off-target retention. +1 more finding

• Brain Biology
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Mutaciones en los genes PSEN1 y PSEN2 como marcadores moleculares en la Enfermedad de Alzheimer. Revisión Sistemática

28/100 ✓ Peer-reviewed Risk genes beyond APOE MQRInvestigar

Key finding: Objetivo: Analizar la evidencia disponible sobre mutaciones en los genes PSEN1 y PSEN2 como marcadores moleculares en la enfermedad de Alzheimer. +4 more findings

• Genetics

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Management and Care for People Living With Dementia and Their Caregivers: Findings From an Italian National Survey on Caregivers and Services Use

47/100 ✓ Peer-reviewed Caregiving Psychogeriatrics

Key finding: A total of 2369 caregivers participated in the survey. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Nutritional knowledge, sociodemographic, and lifestyle factors as determinants of diet quality – a Polish population-based study

49/100 ✓ Peer-reviewed Prevention and risk Frontiers in Public Health

Key finding: Nutritional knowledge supports better diet quality but may not suffice especially in older adults. +2 more findings

• Lifestyle

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APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv : the preprint server for biology

Key finding: These findings suggest that impaired lipid droplet clearance, rather than accumulation, distinguishes APOE4-associated AD risk, and may present a new metabolic node for modulating risk.

• Genetics
• Brain Biology

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Optimizing timing and cost-effective use of plasma biomarkers in Alzheimer's disease

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: When benchmarked against amyloid PET, plasma biomarker-based stratification achieves an optimal balance between diagnostic accuracy and cost-effectiveness. +4 more findings

• Biomarkers
• Policy
• Diagnosis

Full summary, score breakdown and related studies → Original source

Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease

35/100 ✓ Peer-reviewed Vascular contributions Matrix Biology

Key finding: We also identified evidence for abnormal cerebrovascular basement membranes and elevated matrix metalloproteinase 9 ( mmp9) transcription associated with loss of col4a1 . +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Perspectives of Hospice Medical Directors on Challenges and Solutions for Improving Care for Persons Living With Dementias (PLWD) and Their Caregivers

35/100 ✓ Peer-reviewed End-of-life care American Journal of Hospice and Palliative Medicine®

Key finding: A larger proportion of PLWD outlive the 6-month hospice eligibility requirement compared to other terminally ill patients, which leads to high rates of hospice live discharge.

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Interventions for preventing falls in older people in care facilities

63/100 ✓ Peer-reviewed Clinical safety Cochrane Database of Systematic Reviews

Key finding: Critical outcomes were rate of falls (number of falls per unit time) and number of fallers (risk of experiencing one or more falls). +4 more findings

• Prevention
• Policy

Full summary, score breakdown and related studies → Original source

Artificial Intelligence and Personhood in Dementia

33/100 ✓ Peer-reviewed Digital health tools Dementia and Geriatric Cognitive Disorders

Key finding: The unprecedented rise of artificial intelligence (AI) in recent times is unparalleled in history.AI 1 seemingly possesses cognitive abilities that hitherto only humans could boast of -reason, an inimitable, embodied, and finite existence. 47Nonetheless, the ubiquitous abilities of AI can help to en

• Digital Tools

Full summary, score breakdown and related studies → Original source

Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study

62/100 ✓ Peer-reviewed How common it is The Lancet Regional Health - Europe

Key finding: Of 736 patients (245 [33%] female, mean age 68·0 years [SD 11·2], median admission National Institutes of Health Stroke Scale (NIHSS) 3 [IQR 1-5]), 557 (76%) were followed up until death or the end of the study, and 706 (96%) contributed to the PSD analysis. +4 more findings

• Risk Factors

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Race and Ethnicity and Comorbidities Among Medicare Beneficiaries With Young-Onset Dementia

47/100 ✓ Peer-reviewed Disparities JAMA Network Open

Key finding: In 2022, among a total of 2 189 231 Medicare beneficiaries aged 45 to 64 years, 71 092 (3.25%) received a diagnosis of YOD. +4 more findings

• Health Equity
• Policy

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Improving Community-Based Palliative Care Explanations: Insights From Persons Declining Services

37/100 ✓ Peer-reviewed Health systems and care delivery American Journal of Hospice and Palliative Medicine®

Key finding: Community-based palliative care can help seriously ill individuals manage their conditions and improve their quality of life. +4 more findings

• End-of-Life Care

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A nomogram for predicting post-stroke cognitive impairment no dementia in patients with first-ever mild ischemic stroke

50/100 ✓ Peer-reviewed Vascular contributions Frontiers in Neurology

Key finding: This validated nomogram incorporating clinical, biochemical, and neuroimaging biomarkers provides a robust tool for individualized PSCIND risk assessment in first-ever MIS patients, with potential to guide targeted interventions and cognitive monitoring. +1 more finding

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Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

45/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: < 0.1). -ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Exploring the effect of pre-clinical Alzheimer’s disease on blood pressure using Mendelian randomisation and parental dementia as an instrumental variable in UK Biobank

43/100 ✓ Peer-reviewed Long-term cohort studies BMC Medicine

Key finding: Both the higher parental dementia instrument and participant genetic instrument score were associated with higher mean SBP (difference in mean SBP mmHg per 1SD higher score: 0.12, 95% CI 0.06 to 0.17, p < 0.0001, and 0.07, 95% CI 0.00 to 0.13, p=0.037, respectively) but not DBP. +4 more findings

Full summary, score breakdown and related studies → Original source