Newest studies

Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges

53/100 ✓ Peer-reviewed Prevention and risk Frontiers in medicine

Key finding: These pathological changes lead to widespread neuronal damage, significantly impacting daily functioning and quality of life. +2 more findings

• Treatments
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Effects of Mental Imagery on Quality of Life, Cognitive, and Emotional Status in Older Adults with Early-Stage Alzheimer's Disease Dementia: A Randomized Controlled Trial

56/100 ✓ Peer-reviewed Treatments Brain sciences

Key finding: The results indicate that incorporating MI can positively influence cognitive status, emotional status, and the quality of life in older adults diagnosed with early-stage dementia. +3 more findings

• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Insight into cerebral microvessel endothelial regulation of cognitive impairment: A systematic review of the causes and consequences

48/100 ✓ Peer-reviewed Inflammation and the immune system Experimental neurology

Key finding: Finally, we summarize the potential targets of endothelial damage in the development of cognitive dysfunction associated with Alzheimer's disease, vascular dementia, type 2 diabetes mellitus, and physiological aging.

• Brain Biology

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Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease

68/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Of 47 participants enrolled (mean age = 73.8 years; 43% female), 1 dropped out before treatment initiation and 6 before completion, including 2 in the nicotinamide and 4 in the placebo arm. +3 more findings

• Clinical Trials
• Biomarkers

Full summary, score breakdown and related studies → Original source

Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain

43/100 ✓ Peer-reviewed Genetics PLoS computational biology

Key finding: In the brain, we found that ApoE4 and ApoE2 both lead to modified regulation of mitochondrial membrane proteins relative to the wild-type control ApoE3. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Traumatic Brain Injury and Risk of Incident Comorbidities

67/100 ✓ Peer-reviewed Risk factors JAMA Network Open

Key finding: The study consisted of 20 400 patients (9264 female [45.4%]; 1576 Black [7.7%], 3944 Latinx [19.3%], and 10 480 White [51.4%]), including 5100 patients with mTBI (median [IQR] age, 36.0 [25.0-51.0] years), 5100 patients with msTBI (median [IQR age, 35.0 [25.0-52.0] years), and 10 200 matched patients in the control group (median [IQR] age, 36.0 [25.0-51.0] years). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Strong diagnostic performance of plasma ptau217 for CSF biomarker-defined young-onset Alzheimer disease in a diagnostically heterogeneous clinical cohort

42/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: Plasma ptau217 has strong diagnostic performance in distinguishing CSF biomarker-defined AD in a clinically relevant, younger cohort of people with symptoms, adding further weight for a simple diagnostic blood test for AD as a cause of a patient's symptoms. +1 more finding

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Technology literacy and access to digital resources for remote assessment among adults enrolled in Alzheimer's disease research

45/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: Cognitively unimpaired participants had higher odds of digital access (OR:3.75; 95% CI:2.45-5.73) and skill (OR:1.22; 95% CI:1.14-1.30). +2 more findings

• Digital Tools
• Health Equity

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The complex relationship between gut microbiota and Alzheimer's disease: A systematic review

64/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews

Key finding: The gut microbiota communicates bidirectionally with the central nervous system through the gut-brain axis, and alterations in its structure and function can influence the progression of AD. +4 more findings

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Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects

57/100 ✓ Peer-reviewed Inflammation and the immune system Glia

Key finding: We discuss the implications of these findings for the development, progression and ultimately treatment of this complex disease as well as directions for future omics studies in glia cells.

• Brain Biology

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Neuroinflammation in Alzheimer disease

59/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Immunology

Key finding: Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. +3 more findings

• Brain Biology

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Mediterranean diet and brain functional connectivity in a population without dementia

52/100 ✓ Peer-reviewed Prevention and risk Frontiers in neuroimaging

Key finding: Rs-fMRI analysis revealed significant associations between FC and MedDietScore. +4 more findings

• Lifestyle

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The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers

63/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [ 11 C]PiB PET imaging, which has not been replicated with [ 18 F]florbetapir (FBP). +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Cerebrovascular-Specific Extracellular Matrix Bioink Promotes Blood-Brain Barrier Properties

43/100 ✓ Peer-reviewed Vascular contributions Biomaterials research

Key finding: The blood-brain barrier predominantly comprises endothelial cells, and their intercellular communication with pericytes and other cell types regulates neuroinflammation. +4 more findings

• Brain Biology

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Using cerebrospinal fluid biomarkers to diagnose Alzheimer's disease: an Australian perspective

43/100 ✓ Peer-reviewed Tau biomarkers Frontiers in psychiatry

Key finding: Testing of CSF biomarkers via lumbar puncture (LP), including quantification of amyloid-β peptide, total tau protein, and phosphorylated tau, can give insight into underlying pathophysiological changes and provide greater certainty in confirming or excluding the presence of Alzheimer's disease changes compared to standard clinical and radiological assessments. +1 more finding

• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease

58/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications

Key finding: Using a genetic and a pharmacological approach we demonstrate that depletion of microglia before amyloid-β (Aβ) plaque deposition, leads to a reduction in plaque numbers and neuritic dystrophy, confirming their role in plaque initiation. +3 more findings

• Brain Biology

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Dyadic Comparison of Pain and Stress in Alzheimer's Disease and Caregivers

43/100 ✓ Peer-reviewed Caregiving Pain management nursing : official journal of the American Society of Pain Management Nurses

Key finding: Contrary to expectations, pain and mental health measures for PLWAD displayed a trend toward negative correlation with their hair cortisol levels. +4 more findings

• Caregiving

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Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis

69/100 ✓ Peer-reviewed Treatments Ageing research reviews

Key finding: Likewise, reports were analyzed for adverse events associated with ARIA-A and ARIA-H. +4 more findings

• Treatments
• Side Effects

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Plasma p-tau immunoassays in clinical research for Alzheimer's disease

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: HIGHLIGHTS: Different plasma phosphorylated tau (p-tau) species reflect different pathological processes of Alzheimer's disease (AD), with p-tau231 showing the greatest association with the earliest increases in brain amyloid beta (Aβ) accumulation, while p-tau217 shows greater association with both brain Aβ and early tau pathology, and other p-tau and tau fragment species show greater association with later stages of brain tau pathology. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study

53/100 ✓ Peer-reviewed Tau biomarkers Resuscitation

Key finding: We studied the promising Alzheimer biomarker plasma tau phosphorylated at threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care to predict long-term neurological outcomes. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Chaperone-mediated autophagy as a modulator of aging and longevity

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in aging

Key finding: Both of these models are backed by experimental data, and they are not mutually exclusionary. +4 more findings

• Brain Biology

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Emerging Pharmacological Approaches for Psychosis and Agitation in Alzheimer's Disease

43/100 ✓ Peer-reviewed Clinical trials CNS drugs

Key finding: Additionally, we present strategies to optimize the clinical development of new drug candidates. +4 more findings

• Clinical Trials
• Treatments

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Portable, low-field magnetic resonance imaging for evaluation of Alzheimer's disease

55/100 ✓ Peer-reviewed Digital health tools Nature communications

Key finding: Here, we optimize LF-MRI acquisition and develop a freely available machine learning pipeline to quantify brain morphometry and white matter hyperintensities (WMH). +4 more findings

• Brain Scans

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Advance Care Planning in Palliative Care in Asia: Barriers and Implications

43/100 ✓ Peer-reviewed End-of-life care Journal of hospice and palliative care

Key finding: In these three sectors, which are influenced by Confucian values, family involvement plays a significant role in decision-making.

• End-of-Life Care

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Treatment of Alzheimer Disease

43/100 ✓ Peer-reviewed Treatments Continuum (Minneapolis, Minn.)

Key finding: Symptom-oriented treatment has been the mainstay of Alzheimer disease (AD) pharmacotherapy for decades. +3 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source