Newest studies

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

33/100 ✓ Peer-reviewed Genetics JMIR Aging

Key finding: Fifty-four participants (~8% response rate) from the MindCrowd web-based cohort (mean age of 62.39 years; 39 females; and 23 APOE ε4 carriers) completed 75 trials of Super G. +4 more findings

• Genetics
• Risk Factors
• Digital Tools

Full summary, score breakdown and related studies → Original source

O impacto da genética e fatores epigenéticos no desenvolvimento do Alzheimer

27/100 ✓ Peer-reviewed Genetics Brazilian Journal of Implantology and Health Sciences

Key finding: Este estudo consiste em uma revisão de literatura exploratória, qualitativa e transversal. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Interaction of Glucagon-Like Peptide 1 and Its Analogues with Amyloid-β Peptide Affects Its Fibrillation and Cytotoxicity

38/100 ✓ Peer-reviewed Drug development International journal of molecular sciences

Key finding: Meanwhile, the direct interactions of GLP-1RAs with Aβ and their functional consequences remain unexplored. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study

72/100 ✓ Peer-reviewed Clinical trials Alzheimer's & Dementia

Key finding: Exercise intensity did not differentially affect cognitive trajectory. +1 more finding

• Clinical Trials
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Localized Intense Uptake in the Skull on 18 F-Flortaucipir PET/CT

48/100 ✓ Peer-reviewed Brain scans and imaging Clinical nuclear medicine

Key finding: 18 F-Flortaucipir, as a classical Tau protein visualizer, has been widely used in the diagnosis of neurodegenerative diseases, especially Alzheimer disease. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Editorial introduction to the special issue on biomarker-based diagnosis of Alzheimer's disease: A synthesis of the commentaries

43/100 ✓ Peer-reviewed Biomarkers Journal of neuropsychology

Key finding: This enthusiasm was tempered by concerns about the biomarker-only diagnostic approach, including the potential for significant harm (e.g. stigma, depression, suicide) caused by labelling asymptomatic older adults who might otherwise never behaviourally express the underlying disease pathology.

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Practical brain MRI guidelines for anti-Aβ antibody treatment in early symptomatic Alzheimer's disease

45/100 ✓ Peer-reviewed Treatments Japanese journal of radiology

Key finding: These guidelines facilitate the accurate diagnosis and effective management of ARIA; ensure the safe administration of anti-Aβ drugs; and provide a framework for MRI facilities, includes staffing requirements and the use of MRI management systems. +1 more finding

• Treatments
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease

46/100 ✓ Peer-reviewed Vascular contributions NeuroImage

Key finding: • Patients with Parkinson's disease (PD) and cognitive impairment demonstrated a significantly greater burden of white matter hyperintensities (WMH), with the highest burden observed in those with PD dementia. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia

36/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Pharmacology

Key finding: The volatile oil of ATR mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, reducing neuroinflammation, and alleviating vascular risk factors. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia

43/100 ✓ Peer-reviewed Inflammation and the immune system Cell Reports

Key finding: Functional analysis revealed METTL3 and downstream m6A readers, including YTHDF2 and IGF2BP1-3, may regulate the proinflammatory secretome of activated microglia. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study

51/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Alzheimer s Disease

Key finding: TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Neuropsychological phenotypic characteristics in a cohort of community-based older adults: Data from the Framingham Heart Study

44/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer s Disease

Key finding: The number of Trail Making Test - Part B (TMT-B) pen lifts and TMT-B examiner-corrected errors were associated with the dysexecutive phenotype and differentiated it from the CN group (OR = 1.39, 95% CI = 1.28-1.52, p < 0.001, AUC = 0.85 and OR = 3.40, 95% CI = 2.65-4.38, p < 0.001, AUC = 0.92; respectively). +2 more findings

Full summary, score breakdown and related studies → Original source

The role of quantitative EEG biomarkers in Alzheimer’s disease and mild cognitive impairment: applications and insights

45/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: It has been shown that decreased α power and increased θ power within the qEEG spectrum correlate with enhanced AD severity. +3 more findings

• Early Stage
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Research models to study lewy body dementia

42/100 ✓ Peer-reviewed Lewy body dementia Molecular Neurodegeneration

Key finding: While existing animal and cellular models have facilitated significant discoveries in PD and AD research, they lack specificity in capturing LBD's unique pathogenic mechanisms, limiting the exploration of therapeutic avenues for LBD specifically.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Relationship Between Depression and Neurodegeneration: Risk Factor, Prodrome, Consequence, or Something Else? A Scoping Review

50/100 ✓ Peer-reviewed Risk factors Biomedicines

Key finding: Most studies suggest depression may contribute to neurodegeneration, but clinical, neuroimaging, and longitudinal evidence also support its role as a prodrome or consequence, indicating a bidirectional relationship. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory

54/100 ✓ Peer-reviewed Digital health tools npj Parkinson s Disease

Key finding: Scents were ranked by area-under-the-curve values for group classification and results leveraged by 8 published studies with 5853 individuals.

• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source

Detection Bias in EHR-Based Research on Clinical Exposures and Dementia

64/100 ✓ Peer-reviewed How common it is JAMA Network Open

Key finding: Among 228 392 participants from UKB (n = 137 374; mean [SD] age at baseline, 62.5 [4.1] years; 53.8% female) and AOU (n = 91 018; mean [SD] age at baseline, 66.9 [7.8] years; 57.1% female), those with a history of a clinical exposure at baseline had higher dementia incidence rates compared with those without such history. +4 more findings

Full summary, score breakdown and related studies → Original source

Association Between Metabolic Syndrome and Young-Onset Dementia

62/100 ✓ Peer-reviewed How common it is Neurology

Key finding: A total of 1,979,509 participants (mean age, 49.0 years; 51.3% men; 50.7% with MetS) were included. +4 more findings

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Caring for the caregivers: a reflection on the challenges of caring for an older adult with dementia

30/100 ✓ Peer-reviewed Caregiving Cogent Gerontology

Key finding: Caring for an older adult with dementia is associated with high levels of chronic stress that may negatively impact the health of the caregiver.

• Caregiving

Full summary, score breakdown and related studies → Original source

An automated multimodal medical image fusion framework for Alzheimer detection using deep learning

31/100 ✓ Peer-reviewed Brain scans and imaging Journal of Combinatorial Mathematics and Combinatorial Computing

Key finding: These findings are important in understanding this area.

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Harmonized prevalence estimates of dementia in Europe vary strongly with childhood education

55/100 ✓ Peer-reviewed Getting a diagnosis Scientific Reports

Key finding: Prevalence rates vary plausibly with other risk factors such as age and comorbidities associated with dementia.

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A mass-producible macaque model displays a durable Alzheimer-like cognitive deficit and hallmark amyloid-β/tau/neurofilament light chain pathologies

36/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

Key finding: The rodent models have contributed greatly to unravel AD pathogenesis, but these AD models have been shown a modest clinical translational effectiveness. +3 more findings

• Biomarkers

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The development of a guidance document for interprofessional collaborative advance care planning in dementia care

34/100 ✓ Peer-reviewed End-of-life care Journal of Integrated Care

Key finding: The first three elements concerned common awareness of collaborative ACP in dementia care, role clarification for various professions and actively working towards shared goals in collaborative ACP in dementia care. +4 more findings

• End-of-Life Care

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Mild cognitive impairment, Alzheimer's disease dementia, and predictors of driving cessation: A 7-year longitudinal prospective study

46/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: Cox Regression multivariate analysis revealed age (Hazard Ratio-HR 1.080), semantic verbal fluency-SVF (HR 0.822) and Tandem Walking Test modified with simultaneous reverse number counting-mTWT (HR 1.099) as significant predictors of driving cessation. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Thalamus as a neural marker of cognitive reserve in bilinguals with frontotemporal dementia

34/100 ✓ Peer-reviewed Lewy body dementia Bilingualism Language and Cognition

Key finding: The results showed that bilinguals had reduced thalamic volume compared to monolinguals despite having similar cognitive performance. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source