Newest studies

Both Amyloid and Tau Assessments Are Desired Before Initiating Disease-modifying Therapy for Alzheimer Disease: Three Real-world Cases

32/100 ✓ Peer-reviewed Treatments Clinical Nuclear Medicine

Key finding: To the Editor: We have recently highlighted the potential pitfalls of amyloid-beta (Aβ) PET, suggesting that both Aβ and tau assessments are necessary to relate clinical symptoms to Alzheimer disease (AD) pathology.1 Herein, we would like to present 3 additional cases related to the clinical practice of disease-modifying therapy (DMT) for AD. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease

44/100 ✓ Peer-reviewed Tau biomarkers The journal of prevention of Alzheimer's disease

Key finding: Alzheimer disease (AD)-modifying therapies are approved for treatment of early-symptomatic AD. +3 more findings

• Biomarkers
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

The costs of dementia care by US state: Medical spending and the cost of unpaid caregiving

47/100 ✓ Peer-reviewed Costs and economics Journal of Alzheimer's Disease

Key finding: BackgroundThere are 5.5 million people living with dementia in the United States (US), with the cost of unpaid care making up a significant portion of the care costs. +1 more finding

• Policy

Full summary, score breakdown and related studies → Original source

APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease

43/100 ✓ Peer-reviewed Genetics Neuron

Key finding: The apolipoprotein E (APOE) gene is the strongest genetic risk modifier for Alzheimer's disease (AD), with the APOE4 allele increasing risk and APOE2 decreasing it compared with the common APOE3 allele. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis

47/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in human neuroscience

Key finding: Bibliometric analysis is crucial in identifying research gaps and trends and guiding future studies to address unmet needs in understanding and modeling human physiology and pathology.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Central Nervous System-Active Medication Use in Older Adults With and Without Dementia-A Retrospective Cohort Study

56/100 ✓ Peer-reviewed Health systems and care delivery Journal of general internal medicine

Key finding: Dementia diagnosis was associated with decreased slopes of opioid (- 0.2% [- 0.3, - 0.1], p < 0.001) and benzodiazepine (- 0.07% [- 0.11, - 0.03], p < 0.001) use. +1 more finding

• Treatments

Full summary, score breakdown and related studies → Original source

Key informants’ perceptions of telehealth palliative care for people living with dementia in nursing homes

44/100 ✓ Peer-reviewed End-of-life care BMC Geriatrics

Key finding: (n = 14) included NH administrators and other leaders, palliative care providers, telehealth representatives, dementia advocates, a care partner, and a PLWD. +4 more findings

• End-of-Life Care
• Digital Tools

Full summary, score breakdown and related studies → Original source

Longitudinal Analysis of Amyloid PET and Brain MRI for Predicting Conversion from Mild Cognitive Impairment to Alzheimer’s Disease: Findings from the ADNI Cohort

49/100 ✓ Peer-reviewed Mild cognitive impairment Tomography

Key finding: Shape features demonstrated the highest predictive accuracy for conversion, with areas under the curve of 0.891 at baseline and 0.898 at 2 years. +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women

64/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Of 733 participants (mean age 82.5 ± 2.9 years), 164 (22.4%) developed MCI and 93 (12.7%) developed dementia by the follow-up visit. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals

63/100 ✓ Peer-reviewed Digital health tools Nature Communications

Key finding: Using harmonized MRI data from 37,096 participants (45-85 years) in a large multinational dataset of 10 cohort studies, we generated five in silico severity markers that: i) outperformed conventional structural MRI markers with a ten-fold increase in effect sizes, ii) captured subtle patterns at sub-clinical CVM stages, iii) were most sensitive in mid-life (45-64 years), iv) were associated with brain beta-amyloid status, and v) showed stronger associations with cognitive performance than diagnostic CVM status.

• Risk Factors
• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI

42/100 ✓ Peer-reviewed Brain scans and imaging European Radiology Experimental

Key finding: The subdivisions exhibit different pathways, terminations, and structural characteristics. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Assessing brain vascular impairment, white matter lesions and ApoE status as predictors of behavioral and psychological symptoms of dementia (BPSD) in a multicentre sample of patients with Alzheimer's disease: a multidisciplinary retrospective study

37/100 ✓ Peer-reviewed Genetics Annali dell'Istituto superiore di sanita

Key finding: BPSD severity was independent from cognitive impairment, vascular impairment, white matter lesions and ApoE status. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

A head-to-head comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's medRxiv

Key finding: A barrier to recruitment for anti-amyloid trials includes the availability of the same amyloid PET radiotracer to multiple treatment centers. 237 adults with Down syndrome from the Trial-Ready Cohort – Down syndrome and Alzheimer Biomarker Consortium – Down syndrome studies were imaged using T1-w MRI and using PET images of PiB, Florbetapir (FBP), NAV4694 (NAV) or Flutemetamol (FMM) to screen for amyloid plaque (Aβ) burden. +3 more findings

• Down Syndrome
• Clinical Trials
• Brain Scans

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Incidence of Amyloid-Related Imaging Abnormalities in Phase III Clinical Trials of Anti-Amyloid-β Immunotherapy: An Updated Meta-Analysis

71/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Nine phase 3 RCT cohorts from 8 eligible studies were identified, analyzing data from 6,315 patients. +2 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease

68/100 ✓ Peer-reviewed Brain tissue and pathology Molecular neurodegeneration

Key finding: αSyn SAA positivity was more common in Aβ + vs. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuroimaging of psychosis, agitation, and affective disturbance in Alzheimer’s disease, dementia with Lewy bodies, and mild cognitive impairment

45/100 ✓ Peer-reviewed Lewy body dementia International Psychogeriatrics

Key finding: Three factors (psychosis, agitation, and affective disturbance) were extracted for AD. +4 more findings

• Other Dementias
• Early Stage

Full summary, score breakdown and related studies → Original source

Enhancing Mild Cognitive Impairment Auxiliary Identification Through Multimodal Cognitive Assessment with Eye Tracking and Convolutional Neural Network Analysis

41/100 ✓ Peer-reviewed Getting a diagnosis Biomedicines

Key finding: Overall, the combined features model achieved a higher discrimination accuracy than models with single feature sets alone. +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Trends in hospital discharge outcomes among high-risk Medicare beneficiaries before and during the COVID-19 pandemic

35/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs Scholar

Key finding: We found that COVID patients initially experienced substantially longer hospital stays (8.3 vs 4.6 days) and higher 30-day mortality (34% vs 5%) compared to patients without COVID. +3 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function

51/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy

Key finding: Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. +3 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers: The D-CARE Randomized Clinical Trial

79/100 ✓ Peer-reviewed Caregiving JAMA

Key finding: In this randomized trial of dementia care programs, no significant differences existed between health system-based and community-based care interventions nor between either active intervention or usual care regarding patient behavioral symptoms and caregiver strain. +4 more findings

• Clinical Trials
• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers: The IN-PEACE Randomized Clinical Trial

77/100 ✓ Peer-reviewed Caregiving JAMA

Key finding: Among community-dwelling patients with moderate to severe dementia and their caregivers, dementia palliative care, compared with usual care, did not significantly improve patients' neuropsychiatric symptoms through 24 months. +4 more findings

• Clinical Trials
• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Magnitude and Time-Course of Dementia Risk in Stroke Survivors

54/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: In the Research Article "Magnitude and Time-Course of Dementia Risk in Stroke Survivors: A Population-Wide Matched Cohort Study" by Joundi et al., 1 the keys for Figure 3, A-D should indicate red for "Stroke," "Ischemic Stroke," "ICH," and "Stroke," respectively. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Western Mediterranean diet predicts 9-year changes in episodic memory in an adult lifespan sample of Americans

46/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer s Disease

Key finding: A wMD was related to slowed EM declines across sociodemographic populations in a national U.S. sample. +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

Diagnosis of Anosmia in Middle Age, But Not in Older Adulthood, Increases Alzheimer Dementia Risk

47/100 ✓ Peer-reviewed Brain tissue and pathology Clinical and Experimental Otorhinolaryngology

Key finding: After adjusting for various factors, the incidence of Alzheimer dementia was significantly higher in the anosmia group compared to the control group (hazard ratio [HR], 1.15; 95% CI, 1.04-1.28). +3 more findings

• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients

55/100 ✓ Peer-reviewed Mild cognitive impairment Hypertension Research

Key finding: This multi-centric study included 180 consecutive hypertensive patients without medical diseases and/or drugs with known significant effects on cognition but with a not negligible comorbidity burden to avoid a possible "hyper-normality bias". +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source