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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,151–17,175 of 27,380 studies, newest first · page 687 of 1096.

March 2015 18

  1. 2015-03 month only

    [Inflammatory cerebral amyloid angiopathy]

    ✓ Peer-reviewed Treatments Brain and nerve = Shinkei kenkyu no shinpo

    Key finding: Neuropathological findings include frank vasculitis and/or perivascular inflammation with mononuclear or multinucleated giant cells that are associated with amyloid-beta (Aβ)-laden vessels. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2015-03-01

    Innate immunity in Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Nature immunology

    Key finding: Classically AD has been viewed as a neurodegenerative disease of the elderly, characterized by the extracellular deposition of misfolded amyloid-β (Aβ) peptide and the intracellular formation of neurofibrillary tangles. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-03-01

    Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model

    ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: The results suggest that tau oligomerization is not only a consequence of Aβ pathology but also a critical mediator of the toxic effects observed afterward in AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2015-03-01

    Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Neuron

    Key finding: Collectively, our findings reveal that FAD mutations can cause complete loss of Presenilin-1 function in vivo, suggesting that clinical PSEN mutations produce FAD through a loss-of-function mechanism.

    Full summary, score breakdown and related studies → Original source

  5. 2015-03-01

    Mediterranean diet and cognitive function: the SUN project

    ✓ Peer-reviewed Prevention trials The journal of nutrition, health & aging

    Key finding: A higher adherence to the MedDiet might be associated with better cognitive function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2015-03-01

    Cognitive plasticity in older adults: effects of cognitive training and physical exercise

    ✓ Peer-reviewed Prevention trials Annals of the New York Academy of Sciences

    Key finding: Cognitive training, physical activity, and exercise have often been reported to improve cognitive performance in older adults. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2015-03-01

    Screening for cognitive impairment after stroke: A systematic review of psychometric properties and clinical utility

    ✓ Peer-reviewed Cognitive tests and assessment Journal of rehabilitation medicine

    Key finding: Data sources EMBASE, CINAHL, MEDLINE, PsychInfo. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-03-01

    Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and Creutzfeldt-Jakob disease

    ✓ Peer-reviewed Tau biomarkers JAMA neurology

    Key finding: Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypes may pose a diagnostic challenge. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2015-03-01

    Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study

    ✓ Peer-reviewed Risk genes beyond APOE JAMA neurology

    Key finding: Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1)E280A mutation carriers and noncarriers from the world's largest known autosomal dominant Alzheimer disease (AD) kindred. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2015-03-01

    Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Brain : a journal of neurology

    Key finding: Because age is the primary risk factor for Alzheimer's disease, mechanisms of interest must include age-related alterations in protein expression, cell type-specific markers and pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2015-03-01

    Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study

    ✓ Peer-reviewed How common it is JAMA internal medicine

    Key finding: The most common anticholinergic classes used were tricyclic antidepressants, first-generation antihistamines, and bladder antimuscarinics. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2015-03-01

    Cognitive resilience to apolipoprotein E ε4: contributing factors in black and white older adults

    ✓ Peer-reviewed Disparities JAMA neurology

    Key finding: Although APOE ε4 carriers are at high risk for cognitive decline, our findings suggest possible intervention targets, including the enhancement of cognitive reserve and improvement of other psychosocial and health factors, to promote cognitive resilience among black and white APOE ε4 carriers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2015-03-01

    Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density

    ✓ Peer-reviewed Getting a diagnosis JAMA neurology

    Key finding: This study showed that flutemetamol injection labeled with radioactive fluorine 18 was safe and had high sensitivity and specificity in an end-of-life population. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2015-03-01

    2015 Alzheimer's disease facts and figures

    ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: This report discusses the public health impact of Alzheimer’s disease (AD), including incidence and prevalence, mortality rates, costs of care and the overall effect on caregivers and society.

    Full summary, score breakdown and related studies → Original source

  15. 2015-03-01

    Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review

    ✓ Peer-reviewed Prevention and risk The journal of nutrition, health & aging

    Key finding: A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer's disease (AD) and the symptoms of advanced AD may represent a unique continuum. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2015-03-01

    A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

    ✓ Peer-reviewed Genetics Annals of neurology

    Key finding: We provide evidence that 2 common variants within the TREM locus are associated with pathological features of AD and aging-related cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2015-03-01

    Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study

    ✓ Peer-reviewed Genetics JAMA psychiatry

    Key finding: Although the presence of abnormal levels of amyloid-β (Aβ) is associated with higher rates of progression to clinically classified mild cognitive impairment or dementia, little research has evaluated potentially modifiable moderators of Aβ-related cognitive decline, such as anxiety and depressive symptoms. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2015-03-01

    Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment

    ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

    Key finding: While vascular brain injuries (white matter lesions and infarcts) do not seem to influence amyloid pathology, some evidence from amyloid imaging suggests that increased vascular risk is related to increased amyloid burden. +1 more finding

    Full summary, score breakdown and related studies → Original source

February 2015 7

  1. 2015-02-28

    Gaussian process classification of Alzheimer's disease and mild cognitive impairment from resting-state fMRI

    ✓ Peer-reviewed Digital health tools NeuroImage

    Key finding: Our results support the hypothesis that GP-LR models can be effective at performing patient stratification: the implemented model achieves 75% accuracy disambiguating healthy subjects from subjects with amnesic mild cognitive impairment and 97% accuracy disambiguating amnesic mild cognitive impairment subjects from those with Alzheimer's disease, accuracies are estimated using a held-out test set. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2015-02-27

    Cryptotanshinone, an orally bioactive herbal compound from D anshen, attenuates atherosclerosis in apolipoprotein E ‐deficient mice: role of lectin‐like oxidized LDL receptor‐1 ( LOX ‐1)

    ✓ Peer-reviewed Genetics British Journal of Pharmacology

    Key finding: CTS significantly attenuated atherosclerotic plaque formation and enhanced plaque stability in ApoE −/− mice by inhibiting the expression of lectin‐like ox LDL receptor‐1 ( LOX ‐1) and MMP ‐9, as well as inhibiting reactive oxygen species ( ROS ) generation and NF‐κB activation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-02-27

    Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

    ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging

    Key finding: We report that TREM2 expression by microglia is significantly up-regulated upon prion infection. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2015-02-27

    Clinical and imaging features of mixed Alzheimer and vascular pathologies

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: Although epidemiologic studies report that vascular risk factors for arteriosclerosis increase the risk of incident AD, both autopsy and amyloid PET studies indicate that AD and VBI contribute additively, but independently, to the risk of dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2015-02-26

    Understanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection

    ✓ Peer-reviewed Inflammation and the immune system Clinical and Translational Medicine

    Key finding: While much of our insight regarding macrophage functional subtypes has been garnered through elegant studies in mice, which are amenable to genetic manipulation, far less is known about such cells in human tissues, and particularly in the brain under normal, disease, or injurious conditions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2015-02-26

    TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

    ✓ Peer-reviewed TREM2 and immune genetics Cell

    Key finding: Recent genome-wide association studies have shown that a rare R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2015-02-26

    Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

    ✓ Peer-reviewed Mild cognitive impairment Journal of neurochemistry

    Key finding: Our findings suggest that the alteration of mTOR signaling and autophagy occurs at early stages of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →