Newest studies

Alzheimers and Brain Tumor Detection Using Deep Learning

28/100 ✓ Peer-reviewed Brain scans and imaging International Journal of Innovative Science and Research Technology

Key finding: The results may contribute to refining current diagnostic techniques, promoting earlier detection, and assisting in the development of advanced tools for accurate brain tumor diagnosis and treatment planning.

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Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related Dementias Pathology: The Multi‐Ethnic Study of Atherosclerosis

59/100 ✓ Peer-reviewed Getting a diagnosis Journal of the American Heart Association

Key finding: Higher structural stiffness of the carotid artery is associated with cognitive decline, whereas both structural and load‐dependent stiffness are associated with brain structural abnormalities common in Alzheimer disease‐related dementias. +4 more findings

• Diagnosis
• Brain Scans
• Health Equity

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Pulling Back the Curtain on Hospital Dementia Detection: Validation of the Informant‐Based Clinical Dementia Rating

54/100 ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society

Key finding: Of 65 participants (mean age = 79.4 years; women = 54%), 34% had dementia and 32% had CIND. +4 more findings

• Diagnosis
• Care Services

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End-of-Life Care and Health Care Spending for Medicare Beneficiaries With Dementia in Accountable Care Organizations

54/100 ✓ Peer-reviewed Costs and economics JAMA Health Forum

Key finding: Of 162 034 eligible Medicare beneficiaries (mean [SD] age, 85.0 [7.9] years; 94 304 female [58.2%]), 51 191 (31.6%) were attributed to MSSP ACO. +1 more finding

• Policy

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Misfolded α-synuclein co-occurrence with Alzheimer's disease proteinopathy

71/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Syn positivity (synSAA+) co-occurred with T (in synSAA+ vs. synSAA-, 36% vs. 20% T+; Pp = 0.011) and with cognitive impairment (10% vs. 7% mild cognitive impairment; 10% vs. 0% dementia; p = 0.00050). synSAA+ participants' cognitive performance declined ≈ 40% faster than synSAA- for Digit Symbol Substitution, but not other tests. +3 more findings

• Brain Biology

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Multisystem failure, tipping points, and risk of Alzheimer's disease

46/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Hypertension or diabetes before age 62 exerted greater AD risk than APOEε4 alone. +4 more findings

• Risk Factors

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PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In 5xFAD mice, the absence of PLCG2 resulted in reduced TREM2 expression and impaired microglial associations with amyloid beta plaques. +4 more findings

• Genetics
• Brain Biology

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Lectins and neurodegeneration: A glycobiologist's perspective

43/100 ✓ Peer-reviewed TREM2 and immune genetics Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Key finding: The progress of neurodegenerative diseases is associated with a complex activity of the immune system in the brain tissue.

• Brain Biology

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The performance of plasma p-tau217 in Black middle-aged and older adults

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, cardiovascular disease (CVD), and amyloid- and tau-PET-positive status demonstrated higher p-tau217. +4 more findings

• Biomarkers
• Risk Factors

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Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population-based study

64/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: PF and BF were significantly associated with increased likelihoods of dementia, Alzheimer's disease (AD), vascular dementia (VaD), and MCI. +4 more findings

• Biomarkers

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The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis

83/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: Subgroup analyses included (i) MCI versus mild AD; (ii) with versus without concomitant AD medications; and (iii) Apolipoprotein E (ApoE4) carriers versus non-carriers. +4 more findings

• Treatments
• Clinical Trials
• Side Effects

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TRAILBLAZER-ALZ 4: A phase 3 trial comparing donanemab with aducanumab on amyloid plaque clearance in early, symptomatic Alzheimer's disease

88/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Donanemab treatment resulted in earlier and greater AP clearance compared to aducanumab. +4 more findings

• Clinical Trials
• Treatments
• Brain Biology

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Pericyte K ATP Channel Hyperactivity Contributes to Layer IV Cortex Hypoperfusion in Cerebral Small Vessel Disease

31/100 ✓ Peer-reviewed Vascular contributions Physiology

Key finding: Our research, conducted both in vivo and ex vivo, demonstrated a 50% decrease in pressure-induced constriction in the CADASIL ACT zone. +4 more findings

• Other Dementias

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Sharing patient technology preferences with care networks: Stakeholders’ views of the “Let’s Talk Tech” decision aid for dementia care

47/100 ✓ Peer-reviewed End-of-life care Journal of Alzheimer s Disease

Key finding: Care partners completed independent follow-up interviews, and 32 clinicians at four Alzheimer's Disease Research Center-affiliated clinics viewed an LTT report and completed a 10-question survey. +4 more findings

• Digital Tools
• Early Stage

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Planning Ahead: protocol for a randomised trial of advance care planning for community dwelling older adults at increased mortality risk

54/100 ✓ Peer-reviewed End-of-life care BMJ Open

Key finding: An important goal of advance care planning (ACP) is ensuring that patients receive care concordant with their preferences. +4 more findings

• Clinical Trials
• End-of-Life Care

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Efficacy of Sodium Valproate in Behavioral and Psychological Symptoms of Dementia: A Retrospective Observational Study from PUMCH Dementia Cohort

42/100 ✓ Peer-reviewed Clinical safety Current Alzheimer Research

Key finding: Among the 116 patients studied, 62.1% exhibited effective responses, 12.1% showed ineffectiveness, and 25.9% had uncertain outcomes with valproate therapy. +4 more findings

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The importance of the presence of chosen family in preventing peri-operative delirium

55/100 ✓ Peer-reviewed Clinical safety European Journal of Anaesthesiology

Key finding: It remains a common yet underrecognised complication in older surgical patients, significantly influencing recovery, prolonging hospital stays and increasing healthcare costs and workload.1 Although traditionally peri-operative care has prioritised physical stabilisation, effectively addressing POD requires a holistic approach that also considers patients’ emotional and social well being.2 One well established strategy for managing delirium is the active involvement of family and caregivers. +4 more findings

• Caregiving

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Choroid plexus free‐water correlates with glymphatic function in Alzheimer's disease

61/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: At baseline, Aβ+ participants showed higher CP FWf, increased white matter hyperintensity (WMH) volume, and decreased diffusion tensor image analysis along the perivascular space (DTI-ALPS). +4 more findings

• Brain Biology
• Brain Scans

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Directionality bias underpins divergent spatiotemporal progression of Alzheimer‐related tauopathy in mouse models

38/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: Retrograde bias better predicted tau progression than anterograde bias, but our best-fitting biophysical models incorporate the mixed effects of both retrograde- and anterograde-directed spread, with notable tau-strain-specific differences. +3 more findings

• Brain Biology

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Sex differences in amyloid PET in a large, real‐world sample from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) Study

61/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: Females had higher rates of positive amyloid PET visual reads (63% vs. 59%, P < 0.001) and higher Centiloids (CLs; median 48.7 vs. 36.8, p < 0.001). +4 more findings

• Brain Scans

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Regular use of opioids and dementia, cognitive measures, and neuroimaging outcomes among UK Biobank participants with chronic non‐cancer pain

42/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: Regular opioid use was associated with a 20% higher risk of all-cause dementia and a 49% higher risk of vascular dementia (VD) compared with those not using analgesics. +4 more findings

• Brain Scans

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Comment on “Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US”

32/100 ✓ Peer-reviewed Drug development Alzheimer s & Dementia

Key finding: Letter in response to the article by Wang et al. recently published in Alzheimer's & Dementia (Wang W, Wang Q, Qi X, Gurney M, Perry G, Volkow ND, Davis PB, Kaelber DC, Xu R. +2 more findings

• Treatments
• Clinical Trials
• Diagnosis

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Cerebrospinal fluid biomarkers including tau protein and amyloid-beta 42 for early detection and differential diagnosis of Alzheimer's disease

35/100 ✓ Peer-reviewed Tau biomarkers International Journal of Advanced Biochemistry Research

Key finding: CSF t-tau and p-tau181 showed progressive elevation from cognitively normal through advanced AD stages, while Aβ42 demonstrated an inverse pattern with progressive decline. +1 more finding

• Biomarkers
• Diagnosis
• Brain Biology

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Repeated plasma p‐tau217 measurements to monitor clinical progression heterogeneity

63/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Three progression clusters emerged in both cohorts: stable cognition, slow decline, and rapid decline-each including cases initially classified as CN or MCI. +4 more findings

• Early Stage

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Characterizing bidirectional transitions in mild cognitive impairment and post‐reversion based on longitudinal neuroimaging and cognitive assessments

44/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: The probability of reversion increased from 2% at baseline to a maximum of 8% by year 10 before gradual decline thereafter. +4 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source