Newest studies

‘Machine Learning’ multiclassification for stage diagnosis of Alzheimer’s disease utilizing augmented blood gene expression and feature fusion

35/100 ✓ Peer-reviewed Digital health tools Discover Applied Sciences

Key finding: Three blood gene expression datasets of high dimensionality and low sample size (HDLSS) have been utilized in this study, with one dataset exhibiting significant class imbalance. +4 more findings

• Digital Tools
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Long-term exposure to air pollution and risk of dementia among older individuals of a Danish nationwide administrative cohort

51/100 ✓ Peer-reviewed Disparities Environment International

Key finding: Among 934,792 individuals, 81,731 developed dementia over a mean follow-up of 11·6 years.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Ethnoracial Disparities in Advance Care Planning Among People With Alzheimer’s Disease and Related Dementias

45/100 ✓ Peer-reviewed Disparities American Journal of Geriatric Psychiatry

Key finding: Ethnoracial identity was significantly associated with the likelihood of ACP engagement. +4 more findings

• Health Equity

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Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease

47/100 ✓ Peer-reviewed Brain scans and imaging American Journal of Neuroradiology

Key finding: Thirty-two patients met the inclusion criteria (n=11 moderate-to-severe SVD, mean age 72 ± 10 years, 6 women; n = 21 none-to-minimal SVD, mean age 70 ± 10 years, 12 women). +2 more findings

• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

Adherence to Mediterranean Diet and Implications for Cardiovascular Risk Prevention

45/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Significant correlations emerged between higher MEDAS scores and BMI (r = −0.53, p < 0.01), FM% (r = −0.49, p < 0.01), VAT (r = −0.63, p < 0.01), and cIMT (r = −0.88, p < 0.01). +4 more findings

• Lifestyle
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Comparative performance of plasma pTau181/Aβ42, pTau217/Aβ42 ratios, and individual measurements in detecting brain amyloidosis

59/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: The pTau217/Aβ42 ratio demonstrated the highest diagnostic accuracy, with an AUC of 0.927 (0.900-0.954). +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Dose- and pattern- physical activity is associated with lower risk of dementia

56/100 ✓ Peer-reviewed Prevention and risk Journal of Prevention of Alzheimer's Disease

Key finding: Accumulating >300 min/week of MVPA, whether concentrated within 1-2 days or distributed evenly across the week, was associated with a decreased risk of dementia. +3 more findings

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Tirzepatide: a novel therapeutic approach for Alzheimer's disease

43/100 ✓ Peer-reviewed Drug development Metabolic brain disease

Key finding: Together, T2D and obesity are regarded as potential risk factors implicated in the development and progression of Alzheimer's disease (AD), which is the most common neurodegenerative disease and represents the most typical cause of dementia. +4 more findings

• Treatments
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults

44/100 ✓ Peer-reviewed Vascular contributions Journal of the American Heart Association

Key finding: A total of 197 participants were included in the study. +4 more findings

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Association of Leucocyte Telomere Length With Stroke, Dementia, and Late-Life Depression

57/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: The study included 356,173 participants (median age 56 years; 53.69% female). +4 more findings

• Risk Factors

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CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

50/100 ✓ Peer-reviewed Mild cognitive impairment Annals of Clinical and Translational Neurology

Key finding: In PD‐SCD, baseline CSF Aβ42 is associated with cognitive progression. +4 more findings

• Biomarkers
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Recapitulation of Ageism in Artificial Intelligence–Generated Images: Longitudinal Comparative Study

45/100 ✓ Peer-reviewed Digital health tools Journal of Medical Internet Research

Key finding: Representations of White-racialized older adults were 5-fold higher than those of other races in both years. +4 more findings

• Digital Tools

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Machine Learning to Detect Motor Agitation in People With Dementia Using Real-Time Location Data

50/100 ✓ Peer-reviewed Digital health tools American Journal of Geriatric Psychiatry

Key finding: Our findings indicate that using location-based trajectory metrics with clinical measures significantly improves the predictability of motor agitation beyond individual baselines. +4 more findings

• Digital Tools

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Remnant cholesterol lowering in cardiovascular disease risk reduction in statin, ezetimibe, and PCSK9 inhibitor trials: meta-regression analyses

49/100 ✓ Peer-reviewed Prevention and risk European Journal of Preventive Cardiology

Key finding: A total of 43 trials of 327,264 participants with 42,016 major adverse cardiovascular events where included. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain

37/100 ✓ Peer-reviewed Vascular contributions European Journal of Nuclear Medicine and Molecular Imaging

Key finding: This study shows that WMHs do not significantly alter gray matter nicotinic signaling in directly connected regions. +4 more findings

• Brain Scans

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Bridging Gaps in Sundown Syndrome Research: a Scoping Review and Roadmap for Future Multimodal Approaches

40/100 ✓ Peer-reviewed Clinical safety Archives of Clinical Neuropsychology

Key finding: We identified key limitations in traditional assessment methods and classified SS symptoms into five domains: psychomotor symptoms, cognitive and perceptual disturbances, mood and affective symptoms, psychosis, and disruptions in activities of daily living and instrumental activities of daily living. +3 more findings

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Fluorescence Lifetime-Based FRET Biosensors for Monitoring N Terminal Domain-Dependent Interactions of TDP-43 in Living Cells: A Novel Approach for ALS and FTD Drug Discovery

38/100 ✓ Peer-reviewed Brain tissue and pathology ACS Chemical Neuroscience

Key finding: These findings establish both the biosensors and the HTS platform as innovative tools for TDP-43 drug discovery and support an exciting translational approach for targeting TDP-43 proteinopathies.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential

45/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Neurodegeneration

Key finding: EVs are associated with the 43 kDa trans-active response DNA binding protein (TDP-43), aggregates of which are a key pathological feature across the spectrum of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other TDP-43 proteinopathies.

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

The current status, trends, and challenges of Alzheimer’s disease and other dementias in Asia (1990–2036)

42/100 ✓ Peer-reviewed How common it is Frontiers in Public Health

Key finding: In 2021, Asia experienced a 250.44% increase in prevalent cases, a 297.34% rise in mortality, and a 249.54% surge in DALYs for AD and other dementias compared to 1990. +4 more findings

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Assessing the Time for Living and Caring (TLC) Study: Mixed-Methods Feasibility Study of a Web-Based Caregiver Intervention to Improve Respite

36/100 ✓ Peer-reviewed Caregiving JMIR Aging

Key finding: The TLC study used an appropriate design and data collection procedures, along with acceptable recruitment capability. +4 more findings

• Caregiving

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Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice

37/100 ✓ Peer-reviewed Genetics Communications Medicine

Key finding: The apolipoprotein ε4 allele (APOE4) is associated with decreased longevity and increased vulnerability to age-related declines and disorders across multiple systems. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Educación artística y salud emocional: el proyecto ukiyo como propuesta integral para el bienestar en el máster medart

25/100 ✓ Peer-reviewed Health systems and care delivery International Journal of Developmental and Educational Psychology Revista INFAD de psicología

Key finding: Inspired by the Japanese concept Ukiyo , which refers to “living in the present moment,” the project addresses the post-pandemic context where students’ mental health has been significantly impacted. +1 more finding

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Trends and mechanisms of Alzheimer's disease and hearing impairment: A 20-year perspective

52/100 ✓ Peer-reviewed Risk factors Ageing research reviews

Key finding: Alzheimer's disease (AD) and hearing loss (HL) are major age-related public health challenges with emerging evidence suggesting their interconnection. +1 more finding

• Brain Biology

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Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice

46/100 ✓ Peer-reviewed TREM2 and immune genetics Nature aging

Key finding: Genome-wide association studies have identified many gene polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease (LOAD). +2 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Rapid health technology assessment of galantamine for the treatment of Alzheimer's disease: A review

52/100 ✓ Peer-reviewed Health systems and care delivery Medicine

Key finding: We extracted information and pooled the results of the studies for qualitative analyses instead of quantitative meta-analysis. +4 more findings

• Treatments
• Digital Tools
• Policy

Full summary, score breakdown and related studies → Original source