Newest studies

Imaging and Fluid Biomarkers of Alzheimer Disease: Complementation Rather Than Competition

43/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: In addition, new types of blood-based biomarkers are being introduced, holding diagnostic potential together with potentially easy and broad accessibility in the future. +4 more findings

• Biomarkers
• Brain Scans

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Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis

51/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neurology

Key finding: Currently, ample evidence has shown that inflammasomes are closely related to the occurrence and development of Alzheimer's disease. +3 more findings

• Brain Biology

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Association between Serum Levels of Interleukin-6 and Stroke, Cardiovascular Events, and Alzheimer’s Disease Dementia

39/100 ✓ Peer-reviewed Vascular contributions Journal of Atherosclerosis and Thrombosis

Key finding: During a median follow-up period of 4.6 years, stroke, MACEs, and AD dementia occurred in 24, 36, and 21 patients, respectively. +4 more findings

• Risk Factors

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AI-delirium guard: Predictive modeling of postoperative delirium in elderly surgical patients

50/100 ✓ Peer-reviewed Clinical safety PLoS ONE

Key finding: The optimized XGBoost model demonstrated superior performance, achieving an AUC of 0.85. +4 more findings

• Digital Tools

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Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease

42/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Molecular Neuroscience

Key finding: We report 14 TF proteins that showed altered protein expression in the AD group compared to the CO group. +1 more finding

• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting

42/100 ✓ Peer-reviewed Mild cognitive impairment Scientific Reports

Key finding: Baseline MCI diagnosis with the Neuropsychological and Conventional criteria was associated with a comparable risk of dementia over time. +2 more findings

• Early Stage

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Economic Burden of Alzheimer Disease and Related Dementias by Race and Ethnicity, 2020 to 2060

54/100 ✓ Peer-reviewed Caregiving JAMA Network Open

Key finding: Of 31 028 older adults in MEPS, 5184 (10%) were African American; 146 (<1%) American Indian or Alaska Native; 1043 (3%) Asian (Indian, Chinese, or Filipino); 5346 (10%) Latino; 690 (2%) Other Asian, Native Hawaiian, and Pacific Islander; and 18 617 (75%) were White. +4 more findings

• Caregiving
• Health Equity
• Policy

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BIOCHEMICAL MARKERS FOR EARLY DETECTION OF DEMENTIA: A REVIEW OF CURRENT ADVANCES

29/100 ✓ Peer-reviewed Getting a diagnosis Asclepius International Journal of Scientific Health Science

Key finding: Recent studies highlight the significance of plasma phosphorylated tau proteins, neurofilament light chain, and amyloid-beta ratios as reliable biomarkers. +3 more findings

• Diagnosis

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Exercise Prescription in Arrhythmogenic Cardiomyopathy: Finding the Right Balance Between Risks and Benefits

44/100 ✓ Peer-reviewed Prevention and risk Journal of the American Heart Association

Key finding: ACM is one of the most common etiology of sudden cardiac death in athletes and young individuals. +4 more findings

• Lifestyle

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Association of Plasma Phosphorylated Tau 217 With Clinical Deterioration Across Alzheimer Disease Stages

63/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Plasma p-tau217 levels showed a significant increase across advancing AD stages, with all between-group comparisons remaining significant after false discovery rate adjustment ( p p = 0.002) and CSF p-tau181 (β = 3.2, 95% CI 1.4-5.0, p = 0.001). +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Economic Burden of Alzheimer Disease and Related Dementias by Race and Ethnicity, 2020 to 2060

61/100 ✓ Peer-reviewed Costs and economics JAMA Network Open

Key finding: Total US economic burden of ADRD projected to rise from $344 billion (2020) to over $3 trillion (2060) +3 more findings

• Health Equity
• Policy

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A Systematic Review of the Efficacy and Safety of Anti-amyloid Monoclonal Antibodies in Alzheimer's Disease

72/100 ✓ Peer-reviewed Treatments Cureus

Key finding: While statistically significant, the 27% ADCOMS (Alzheimer's Disease Composite Score) reduction warrants comparison to MCID (minimal clinically important difference) thresholds (e.g., ~0.5-1.0 points for CDR-SB in early AD) to assess real-world impact. +1 more finding

• Treatments
• Side Effects
• Clinical Trials

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Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration

43/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia. Behavior & socioeconomics of aging

Key finding: Neighborhood deprivation is associated with shorter survival, cognitive impairment and neurodegeneration in aging and Alzheimer's disease. +2 more findings

• Other Dementias

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Drivers with dementia: Forecasting the future

47/100 ✓ Peer-reviewed Clinical safety Journal of Alzheimer s Disease

Key finding: BackgroundA decline in driving skills is well documented in people with dementia. +2 more findings

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Student satisfaction of a dementia education intervention: a cross-sectional study of the time for dementia programme

42/100 ✓ Peer-reviewed Disparities BMC Medical Education

Key finding: 78% of students agreed or strongly agreed that Time for Dementia had increased their knowledge of psychosocial issues, and 69% enjoyed the programme. +4 more findings

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In Silico Design and Molecular Docking of Dalfina: A Tau-Targeting Small Molecule for Alzheimer's Disease Therapy

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Authorea Preprints

Key finding: Dalfina was optimized to selectively bind hyperphosphorylated tau isoforms and demonstrated favorable physicochemical properties for blood-brain barrier (BBB) permeability. +2 more findings

• Treatments

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Alzheimer's disease drug development pipeline: 2025

46/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)

Key finding: Clinical trials for Alzheimer's disease (AD) must be registered on clinicaltrials.gov.

• Treatments

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Comparisons of efficacy and safety of immunotherapies for Alzheimer's disease treatment: A network meta-analysis of randomised controlled trials

71/100 ✓ Peer-reviewed Treatments Clinical medicine (London, England)

Key finding: Donanemab and lecanemab ranked among the most effective treatments for improving cognitive function (Clinical Dementia Rating Scale - Sum of Boxes P-scores: 0.88 and 0.77) and daily activities (Alzheimer's Disease Cooperative Study - Activities of Daily Living P-scores: 0.85 and 0.90), based on network meta-analysis findings. +2 more findings

• Treatments

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Managing Cognitive Decline Through a Social Robot–Based Intervention: Protocol for the engAGE Proof of Concept and Randomized Controlled Trial

59/100 ✓ Peer-reviewed Prevention trials JMIR Research Protocols

Key finding: Data collection commenced in November 2023 and finished in July 2024, with the enrollment of 49 older adults with MCI (n=40, 81.6%, assigned to the experimental group [EG] and n=9, 18.4%, to the control group [CG]) conducted from October 2023 to April 2024. +4 more findings

• Clinical Trials
• Lifestyle
• Digital Tools

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Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer’s disease cohort

54/100 ✓ Peer-reviewed Disease mechanisms Scientific Reports

Key finding: Amyloid burden impacts cognitive decline in the pre-dementia stages of Alzheimer's disease (AD), but there remains significant variability in cognitive trajectories that may be explainable by markers of synaptic function and neurodegeneration. +1 more finding

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia

41/100 ✓ Peer-reviewed Inflammation and the immune system Fluids and Barriers of the CNS

Key finding: AMS-17 treatment improved cognitive function, enhanced blood-brain barrier (BBB) integrity, and promoted remyelination in VaD mice. +4 more findings

• Brain Biology
• Treatments

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Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank

43/100 ✓ Peer-reviewed Long-term cohort studies Stroke and Vascular Neurology

Key finding: During a median follow-up of 13.68 years, 4744 incident all-cause dementia (ACD) events (including 3013 Alzheimer's disease (AD) and 853 vascular dementia (VaD)) were recorded. +4 more findings

• Risk Factors

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Dynamic cerebral autoregulation in people with mild cognitive impairment

37/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Cerebral Blood Flow & Metabolism

Key finding: Dynamic cerebral autoregulation (dCA), a measure of the cerebral vasculature’s ability to buffer abrupt changes in mean arterial pressure and prevent hypoperfusion, such as during a supine-to-standing transition, have mixed results in people clinically diagnosed with mild cognitive impairment (MCI, people with objective cognitive impairment but maintained functional independence). +4 more findings

• Early Stage

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Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study

47/100 ✓ Peer-reviewed Mild cognitive impairment BMC Oral Health

Key finding: Of the participants, 25, 92, and 61 were classified as cognitively normal, with mild cognitive impairment, and with dementia, respectively. +4 more findings

• Early Stage

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Differentiating patients with dementia from patients with depression and healthy controls using the Cognitive Functions Dementia (CFD) test set and machine learning

40/100 ✓ Peer-reviewed Digital health tools The Clinical Neuropsychologist

Key finding: Using raw data from the CFD and the GLMnet algorithm, we could accurately differentiate between DEM vs. +3 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source