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37/100

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Altered cerebrovascular hemodynamics and low cerebral perfusion contribute to the development and progression of dementia. Dynamic cerebral autoregulation (dCA), a measure of the cerebral vasculature’s ability to buffer abrupt changes in mean arterial pressure and prevent hypoperfusion, such as during a supine-to-standing transition, have mixed results in people clinically diagnosed with mild cognitive impairment (MCI, people with objective cognitive impairment but maintained functional independence). Therefore, in 30 people with MCI, we tested the hypothesis that participants with a higher standing middle cerebral artery velocity (MCAv) at diastole (higher-velocity group) would have lower dCA values, to confer better cerebrovascular outcomes and enhanced cognitive function compared to participants with a lower MCAv at diastole (lower-velocity group). This study separated people with MCI into different diastolic MCAv groups. dCA was calculated as (MCAv nadir -MCAv supine /MCAv supine )/(MAP MCAnadir -MAP MCAsupine /MAP MCAsupine ). This work led to the identification of a dysregulated dCA in the higher-velocity group (p = 0.009) compared to the lower-velocity group despite having greater cognitive scores (p = 0.008). Elevated levels of cerebral oxygen tissue saturation (p = 0.039) and lower end-tidal carbon dioxide (p = 0.042) suggest that a favourable dCA value may be a compensatory mechanism in the neurodegenerative disease processes. The unexpected results highlight the importance of uncovering hemodynamic pathways in clinical populations.

Key findings

Dynamic cerebral autoregulation (dCA), a measure of the cerebral vasculature’s ability to buffer abrupt changes in mean arterial pressure and prevent hypoperfusion, such as during a supine-to-standing transition, have mixed results in people clinically diagnosed with mild cognitive impairment (MCI, people with objective cognitive impairment but maintained functional independence).
Therefore, in 30 people with MCI, we tested the hypothesis that participants with a higher standing middle cerebral artery velocity (MCAv) at diastole (higher-velocity group) would have lower dCA values, to confer better cerebrovascular outcomes and enhanced cognitive function compared to participants with a lower MCAv at diastole (lower-velocity group).
This work led to the identification of a dysregulated dCA in the higher-velocity group (p = 0.009) compared to the lower-velocity group despite having greater cognitive scores (p = 0.008).
Elevated levels of cerebral oxygen tissue saturation (p = 0.039) and lower end-tidal carbon dioxide (p = 0.042) suggest that a favourable dCA value may be a compensatory mechanism in the neurodegenerative disease processes.
The unexpected results highlight the importance of uncovering hemodynamic pathways in clinical populations.

Why it matters

In 30 people with mild cognitive impairment, this study found dysregulated dynamic cerebral autoregulation in a higher-velocity group despite better cognitive scores. As a small study, it describes a physiological difference and does not test any treatment, cure, or prevention.

Study details

Participants30
Evidence strengthLow

How this study scored 37/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Cerebral Blood Flow & Metabolism)
Journal's citation record	3 / 4	Journal of Cerebral Blood Flow & Metabolism: journal h-index 285 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	30 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Jaspreet S. Bhangu: h-index 13 (OpenAlex, whole career)
Institution's track record	1 / 3	Western University: institution h-index 899 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40458006)
Free to read	2 / 2	Free to read
Total	37 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Fitzgibbon‐Collins, L. K., BORRIE, M. J., Peters, S., Shoemaker, J. K., & Bhangu, J. S. (2025). Dynamic cerebral autoregulation in people with mild cognitive impairment. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1177/0271678x251345361

Vancouver

Fitzgibbon‐Collins LK, BORRIE MJ, Peters S, Shoemaker JK, Bhangu JS. Dynamic cerebral autoregulation in people with mild cognitive impairment. Journal of Cerebral Blood Flow & Metabolism. 2025. doi:10.1177/0271678x251345361. PMID: 40458006.

BibTeX

@article{fitzgibboncollins2025-40458006,
  author  = {Fitzgibbon‐Collins, Laura Keiko and BORRIE, MICHAEL J. and Peters, Sue and Shoemaker, J. Kevin and Bhangu, Jaspreet S.},
  title   = {{Dynamic cerebral autoregulation in people with mild cognitive impairment}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2025},
  doi     = {10.1177/0271678x251345361},
  pmid    = {40458006},
  url     = {https://doi.org/10.1177/0271678x251345361}
}

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