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Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting
Simone Galati, Michele Rossi, Federica Del Signore, Giulia Chiavegato Locatelli, Antonio Guaita, Elena Rolandi. Scientific Reports, 2025-06-05
Topic: Risk, prevention and care in population studies
Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction. However, there is currently no agreement on the MCI criteria, leading to wide heterogeneity in the prognosis of MCI patients and high reversion rates. Our study aimed to compare the prognostic value of Conventional (Petersen/Winblad) and Neuropsychological (Jak/Bondi) criteria for the diagnosis of MCI. We directly compared the ability of each classification method to predict progression to dementia and the stability of the diagnosis over 12 years in a population-based sample of 1021 older adults without dementia. The relative impact of subjective complaints and objective impairment on clinical progression was further evaluated. Baseline MCI diagnosis with the Neuropsychological and Conventional criteria was associated with a comparable risk of dementia over time. Across the study period, the Neuropsychological criteria led to more consistent diagnoses (63.2% vs. 43.2%). The copresence of subjective memory complaints and objective impairment at baseline was associated with increased dementia risk within both diagnostic frameworks. These results further support the use of comprehensive neuropsychological assessment to make timely and appropriate MCI diagnoses and show the added prognostic value of subjective complaints.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Galati, S., Rossi, M., Del Signore, F., Locatelli, G. C., Guaita, A., & Rolandi, E. (2025). Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting. Scientific Reports. https://doi.org/10.1038/s41598-025-04275-y
Vancouver
Galati S, Rossi M, Del Signore F, Locatelli GC, Guaita A, Rolandi E. Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting. Scientific Reports. 2025. doi:10.1038/s41598-025-04275-y. PMID: 40473666.
BibTeX
@article{galati2025-40473666,
author = {Galati, Simone and Rossi, Michele and Del Signore, Federica and Locatelli, Giulia Chiavegato and Guaita, Antonio and Rolandi, Elena},
title = {{Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting}},
journal = {Scientific Reports},
year = {2025},
doi = {10.1038/s41598-025-04275-y},
pmid = {40473666},
url = {https://doi.org/10.1038/s41598-025-04275-y}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Baseline MCI diagnosis with the Neuropsychological and Conventional criteria was associated with a comparable risk of dementia over time.
- The copresence of subjective memory complaints and objective impairment at baseline was associated with increased dementia risk within both diagnostic frameworks.
- These results further support the use of comprehensive neuropsychological assessment to make timely and appropriate MCI diagnoses and show the added prognostic value of subjective complaints.
Why it matters
This study compared two sets of diagnostic criteria for MCI in 1021 older adults over 12 years and found both predicted dementia risk similarly, though the Neuropsychological criteria gave more consistent diagnoses. It also found that having both subjective memory complaints and objective impairment at baseline was linked to higher dementia risk, supporting comprehensive neuropsychological assessment for timely diagnosis.
Study details
- Effect size63.2%; 43.2%
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 40 of the 96 points we could judge it on, which is 42 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific Reports) |
| Journal's citation record | 3 / 4 | Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | University of Pavia: institution h-index 809 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40473666) |
| Free to read | 2 / 2 | Free to read |
| Points | 40 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 40 of the 96 points we could judge it on is 42 out of 100. |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s41598-025-04275-y
- PubMed: 40473666
- Original source →
- Free full text: Scientific Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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