Newest studies

A village doctor-led mobile health intervention for cardiovascular risk reduction in rural China: cluster randomised controlled trial

70/100 ✓ Peer-reviewed Prevention and risk BMJ

Key finding: Enrolment took place between March 2023 and May 2023. +2 more findings

• Clinical Trials
• Risk Factors
• Prevention

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Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement

55/100 ✓ Peer-reviewed Prevention and risk European Heart Journal

Key finding: Specifically, a growing body of evidence suggests that vaccines against influenza, SARS-CoV-2, respiratory syncytial virus, herpes zoster, and other viruses significantly reduce infection and for influenza the incidence of major adverse cardiovascular events in vaccinated individuals.

• Prevention
• Risk Factors

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Evaluating the Cost-Effectiveness of Pharmacological Therapy in Alzheimer Disease in Brazil

41/100 ✓ Peer-reviewed Treatments Value in Health Regional Issues

Key finding: In the base-case analysis from the healthcare perspective, SoC was more clinically effective than BSC with a cost per QALY of $5211. +2 more findings

• Policy
• Treatments

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Adverse Social Exposome During the Life Course and Vascular Brain Injury

60/100 ✓ Peer-reviewed Risk factors JAMA Network Open

Key finding: The sample included 740 donors (417 female [56.4%]; mean [SD] age at death, 81.5 [10.3] years; mean [SD] VBI score, 0.7 [1.0]; and median life course ADI, 7.08 [IQR, 4.33-9.83]), with residential years spanning 1905 to 2018. +4 more findings

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Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

45/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: The emerging class of bispecific antibodies represents a significant advancement in Alzheimer's disease (AD) immunotherapy by addressing the limited brain concentrations achieved with conventional monoclonal antibodies. +2 more findings

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease

32/100 ✓ Peer-reviewed Vascular contributions The Egyptian Journal of Neurology Psychiatry and Neurosurgery

Key finding: OCTA is a handy, noninvasive tool that enables the visualization of diminished retinal microvascular density in cases of early CSVD. +2 more findings

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Directed acyclic graphs to minimise bias and optimise causal inference in SNAP-3: an observational cohort study of frailty, multimorbidity, and delirium in older surgical patients

55/100 ✓ Peer-reviewed Clinical safety British Journal of Anaesthesia

Key finding: DAGs provide visual representations of assumptions made, and provide an objective approach to appropriate statistical adjustments. +4 more findings

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Cerebral amyloid angiopathy in patients with Dementia with Lewy Bodies: A clinical and hippocampal morphology study

35/100 ✓ Peer-reviewed Brain tissue and pathology Parkinsonism & Related Disorders

Key finding: 87 DLB patients (77.5 ± 7.2yo; 34.5 % females) were included. +3 more findings

• Other Dementias

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Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank

51/100 ✓ Peer-reviewed Long-term cohort studies The Journal of Prevention of Alzheimer s Disease

Key finding: A total of 43,160 participants were included (mean [standard deviation] age, 64.2 [7.7] years, 53.1 % female). +4 more findings

• Brain Scans

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Prediction of mild cognitive impairment using blood multi-omics data

36/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Genetics

Key finding: We demonstrated, for the first time, that data at a genome structure level such as CNVs could be as informative as gene expression data to classify MCI patients from normal controls. +2 more findings

• Early Stage

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Long-term health conditions and their impact on people with sleep disturbances and dementia

40/100 ✓ Peer-reviewed Risk factors BMC Geriatrics

Key finding: Firstly, there was a complex interaction of LTCs, sleep and dementia. +4 more findings

• Lifestyle

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Sex differences in risk factors for Alzheimer dementia encephalopathy patients

56/100 ✓ Peer-reviewed Risk factors Frontiers in Dementia

Key finding: Our analysis identified risk factors that contribute to sex differences in ADEN. +3 more findings

• Risk Factors

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Experiences of dementia in farming communities: A scoping review

39/100 ✓ Peer-reviewed Disparities Journal of Rural Studies

Key finding: Farming communities experience significant rates of dementia, however research exploring the support needs of this population is scarce.

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Non-traditional socio-environmental and geospatial determinants of Alzheimer's disease-related dementia mortality

43/100 ✓ Peer-reviewed Risk factors The Science of The Total Environment

Key finding: Ambient air pollution interacts with SVI to influence ADRD mortality rates. +2 more findings

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Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

46/100 ✓ Peer-reviewed Vascular contributions Annals of Clinical and Translational Neurology

Key finding: Pulse pressure, but not mean arterial pressure, significantly mediated the relationship between age and white matter hyperintensity load. +4 more findings

• Brain Scans
• Risk Factors

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Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia

41/100 ✓ Peer-reviewed Lewy body dementia npj Aging

Key finding: Based on microarray data of GSE122063, bioinformatic analysis revealed 502 DEGs in the frontal and 674 DEGs in the temporal cortex of VaD patients. +1 more finding

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy

37/100 ✓ Peer-reviewed Lewy body dementia Theranostics

Key finding: : Integrating clinical bioinformatics with computational drug design, this study establishes a translational paradigm for nanomaterial development. +1 more finding

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores

48/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: Our findings support speech-based cognitive assessments as a promising avenue towards remote MCI screening, with implications for scalable screening in clinical trials and healthcare. +2 more findings

• Diagnosis
• Early Stage
• Digital Tools

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A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer's disease

68/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: We included 400 middle-aged CU participants, of whom 135 (33.8%) were CSF Aβ-positive. +4 more findings

• Biomarkers

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The Epidemiology of Social Isolation and Loneliness Among Family and Unpaid Caregivers of Older Adults: Findings From the National Study of Caregiving

48/100 ✓ Peer-reviewed Risk factors The Journals of Gerontology Series B

Key finding: About 12% of caregivers (2.8 million) were socially isolated and 27% (6.3 million) were lonely. +4 more findings

• Caregiving
• Lifestyle

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Epidemiological and sociodemographic transitions in the global burden and risk factors for Alzheimer's disease and other dementias: a secondary analysis of GBD 2021

43/100 ✓ Peer-reviewed Disparities International Journal for Equity in Health

Key finding: Globally, 9.84 million cases of ADOD occurred in 2021, with 1.95 million ADOD-related deaths, causing 36.33 million DALYs. +4 more findings

• Risk Factors

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Multicomponent Exercise and Functional Fitness: Strategies for Fall Prevention in Aging Women

59/100 ✓ Peer-reviewed Prevention and risk Sports

Key finding: Aging is associated with physiological changes that increase the risk of falls, impacting functional independence and quality of life. +3 more findings

• Lifestyle
• Clinical Trials
• Prevention

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Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC

40/100 ✓ Peer-reviewed Treatments Alzheimer s Research & Therapy

Key finding: In total, 24 recommendations were developed covering the research landscape and priorities within research in AD following a possible approval, potential impact on health care systems and diagnostic pathways, and communication to patients about anti-amyloid antibodies. +4 more findings

• Treatments

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Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease

43/100 ✓ Peer-reviewed Disease mechanisms Behavioural brain research

Key finding: Using a mouse model of 5xFAD, we found that physical exercise (PE) promoted the clearance of ER fragments and inhibited the ER stress via ER autophagy (ER - Phagy). +2 more findings

• Brain Biology
• Lifestyle

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Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease

68/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

Key finding: Sub-analysis of CSF biomarkers of neuronal damage, inflammation, and microglial activity was performed in a subset of patients treated with a placebo (n = 21) versus resveratrol (n = 30). +3 more findings

• Clinical Trials
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source