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Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study
Yuichi Ishihara, Akira Taguchi, Shiho Yunoue, Misaki Mugiyama, Kazumi Hosokubo, Minami Ido, Kaori Nohara, Momo Shinmei et al.. BMC Oral Health, 2025-06-03
Topic: Risk, prevention and care in population studies
Of the participants, 25, 92, and 61 were classified as cognitively normal, with mild cognitive impairment, and with dementia, respectively. Oral diadochokinesis /ka/ was associated with a high risk of mild cognitive impairment: adjusted odds ratio, 6.930 (95% confidence interval: 1.284-37.402, P = 0.024). Repetitive salivary swallowing test score was associated with a high-risk tendency for dementia: adjusted odds ratio, 4.171 (95% confidence interval: 0.981-17.736, P for trend = 0.053). Number of present teeth, occlusal force, and tongue pressure were not associated with mild cognitive impairment or dementia. Oral diadochokinesis /ka/ was independently associated with mild cognitive impairment. A well-designed cohort study is needed to clarify the causal relationships between cognitive decline and oral diadochokinesis. The ability to identify study participants with possible mild cognitive impairment through regular dental examinations would help to prevent dementia. TRIAL REGISTRATION: This study was registered to UMIN Clinical Trials Registry (UMIN000048126) at 2022-06-21.
Key findings
- Of the participants, 25, 92, and 61 were classified as cognitively normal, with mild cognitive impairment, and with dementia, respectively.
- Oral diadochokinesis /ka/ was associated with a high risk of mild cognitive impairment: adjusted odds ratio, 6.930 (95% confidence interval: 1.284-37.402, P = 0.024).
- Repetitive salivary swallowing test score was associated with a high-risk tendency for dementia: adjusted odds ratio, 4.171 (95% confidence interval: 0.981-17.736, P for trend = 0.053).
- Number of present teeth, occlusal force, and tongue pressure were not associated with mild cognitive impairment or dementia.
- Oral diadochokinesis /ka/ was independently associated with mild cognitive impairment.
Why it matters
This study found that a specific oral movement task, oral diadochokinesis /ka/, was independently associated with mild cognitive impairment. This suggests that dental examinations could help identify possible cognitive impairment, but no treatment or prevention is tested.
Study details
- Study designcohort study
- Effect size49.4%
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMC Oral Health) |
| Journal's citation record | 1 / 4 | BMC Oral Health: journal h-index 113 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Kenji Matsushita: h-index 34 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | National Center for Geriatrics and Gerontology: institution h-index 249 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40462097) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s12903-025-06289-4
- PubMed: 40462097
- Original source →
- Free full text: BMC Oral Health →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Ishihara, Y., Taguchi, A., Yunoue, S., Mugiyama, M., Hosokubo, K., Ido, M., et al. (2025). Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study. BMC Oral Health. https://doi.org/10.1186/s12903-025-06289-4
Vancouver
Ishihara Y, Taguchi A, Yunoue S, Mugiyama M, Hosokubo K, Ido M, et al. Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study. BMC Oral Health. 2025. doi:10.1186/s12903-025-06289-4. PMID: 40462097.
BibTeX
@article{ishihara2025-40462097,
author = {Ishihara, Yuichi and Taguchi, Akira and Yunoue, Shiho and Mugiyama, Misaki and Hosokubo, Kazumi and Ido, Minami and Nohara, Kaori and Shinmei, Momo and others},
title = {{Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study}},
journal = {BMC Oral Health},
year = {2025},
doi = {10.1186/s12903-025-06289-4},
pmid = {40462097},
url = {https://doi.org/10.1186/s12903-025-06289-4}
}
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