Newest studies

Fentanyl Test Strip Use and Overdose Risk Reduction Behaviors Among People Who Use Drugs

65/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: The study included 732 participants (median [IQR] age, 41 [34.0-48.0] years; 369 [50.4%] male; 64 [8.9%] Black or African American, 587 [81.3%] White, and 71 [9.8%] other races); 414 reported baseline FTS use and 318 did not. +4 more findings

• Prevention

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Dampening of Microglial Activation With Nasal Foralumab Administration in Moderate Alzheimer’s Disease Dementia

43/100 ✓ Peer-reviewed Treatments Clinical Nuclear Medicine

Key finding: A 78-year-old man with moderate Alzheimer disease (AD) dementia was treated with nasal-foralumab, a fully human anti-CD3 monoclonal antibody, as part of a Food and Drug Administration expanded-access-program, based on previously demonstrated efficacy of anti-CD3 antibody in animal models. 18 F-PBR06-PET, utilizing a second-generation 18-kDa-translocator-protein ligand targeting microglia, showed diffuse reduction of radiotracer uptake throughout the brain, following 3 months of nasal-foralumab compared with baseline.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Long-Term Exposure to Ambient Particulate Matter and Structural Brain Changes in Older Adults

68/100 ✓ Peer-reviewed Risk factors Stroke

Key finding: At study entry, the mean (SD) age of the participants was 70 (SD, 8.9) years and 41% were males. +4 more findings

• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

TAU PET HARMONIZATION VIA SURFACE-BASED DIFFUSION MODEL

43/100 ✓ Peer-reviewed Brain scans and imaging Proceedings. IEEE International Symposium on Biomedical Imaging

Key finding: The heterogeneity inherent in tau positron emission tomography (PET) imaging data across different tracers challenges the integration of multi-site tau PET data, thereby necessitating the trustful harmonization technique for a better utilization of the emerging large-scale datasets. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

PLASMA-CYCLEGAN: PLASMA BIOMARKER-GUIDED MRI TO PET CROSS-MODALITY TRANSLATION USING CONDITIONAL CYCLEGAN

43/100 ✓ Peer-reviewed Biomarkers Proceedings. IEEE International Symposium on Biomedical Imaging

Key finding: By evaluating three widely used cross-modality translation models, we found that BBBMs integration consistently enhances the generative quality across all models. +2 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Monoclonal antibody administration in an academic institution and private neurological practice: a tale of two clinics

50/100 ✓ Peer-reviewed Treatments Journal of neurology

Key finding: Challenges with MAB adoption into clinical practice may vary depending on whether the institution is an academic/integrated healthcare organization versus a private neurological practice. +4 more findings

• Treatments
• Diagnosis

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R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 19

35/100 ✓ Peer-reviewed Health systems and care delivery Journal of comparative effectiveness research

Key finding: In this update, we examine a checklist for real-world evidence use in Medicare drug price negotiations under the Inflation Reduction Act, a review of health technology assessment reassessments across major health technology assessment agencies, and two complementary studies that used natural experiment approaches to explore the relationship between herpes zoster vaccination and reduced dementia risk.

• Digital Tools
• Policy

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History of hypertensive disorders of pregnancy and risk of Alzheimer’s disease and vascular dementia

38/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Neuroendocrinology

Key finding: Thus, it is plausible that pregnancy experience, which is unique to women, may play a contributing role. +4 more findings

• Other Dementias
• Risk Factors

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Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies

48/100 ✓ Peer-reviewed Lewy body dementia npj Parkinson s Disease

Key finding: Compared to controls, DLB exhibited increased MD and FWF, reduced tNDI across multiple regions, and focal ODI reductions in the occipital cortex. +2 more findings

• Other Dementias

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Language, literacy, and sensory impairments and missing cognitive test scores in the Harmonized Cognitive Assessment Protocol of the China Health and Retirement Longitudinal Study

57/100 ✓ Peer-reviewed Getting a diagnosis Aging Clinical and Experimental Research

Key finding: We observed high levels of missing data in most cognitive test items - on average 13% and as high as 65%. +4 more findings

• Diagnosis

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The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC

46/100 ✓ Peer-reviewed Prevention and risk Seminars in Cancer Biology

Key finding: Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

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The two cut-offs approach for plasma p-tau217 in detecting Alzheimer's disease in subjective cognitive decline and mild cognitive impairment

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Plasma p-tau217 was accurate for discriminating between Core1+ and Core1- patients (area under the curve = 0.92) with an optimal cut-off value of 0.274 pg/mL, revealing good accuracy (86.29%), positive predictive value (PPV; 88.18%), and negative predictive value (NPV; 83.09%). +3 more findings

• Biomarkers
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer's disease

60/100 ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine

Key finding: We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. +4 more findings

• Diagnosis
• Early Stage
• Digital Tools

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Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit

48/100 ✓ Peer-reviewed Biomarkers Scientific Reports

Key finding: A nomogram and a double cut-off strategy were proposed to visualize the model results, and stratify patients (AD, non-AD, uncertain), respectively.

• Biomarkers
• Genetics
• Diagnosis

Full summary, score breakdown and related studies → Original source

The Impact of Delirium on Hospitalized Patients With COPD Exacerbation: Insights From the National In-Patient Sample

44/100 ✓ Peer-reviewed Clinical safety Respiratory Care

Key finding: A total of 8,062,333 subjects hospitalized with COPD exacerbation were included, of whom 574,005 (7.2%) had a diagnosis of delirium. +4 more findings

• Care Services

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Models and mechanisms of post-stroke dementia and cognitive impairment

40/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Stroke

Key finding: Stroke is a leading cause of death and disability globally, with significant long-term impacts such as post-stroke cognitive impairment (PSCI).

• Brain Biology

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Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study

39/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: value = 0.04). ε4 on cognition is mediated by structural brain imaging markers, driven mainly by cerebral microbleeds. +1 more finding

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Data-driven characterization of distinct cognitive subtypes in Parkinson’s disease dementia

42/100 ✓ Peer-reviewed Cognitive tests and assessment npj Parkinson s Disease

Key finding: These findings reveal distinct memory-predominant and visuospatial-predominant PDD subtypes, which associate with different clinical and genetic features but are independent of comorbid Alzheimer's pathology.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Psychometric Performance of the EQ Health and Wellbeing in Caregivers of Persons Living With Dementia

42/100 ✓ Peer-reviewed Caregiving Value in Health

Key finding: In known-group validity analysis, the EQ-HWB instruments performed similarly to the C-DEMQOL in terms of effect sizes across a range of variables and slightly better than the CarerQol on some variables. +3 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Advances in immunotherapy for Alzheimer's Disease 2020-2023 – a literature review

27/100 ✓ Peer-reviewed Treatments Journal of Education Health and Sport

Key finding: Recent years have seen a large increase in research directed at AD immunotherapy. +4 more findings

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Expression of Concern: Paladugu et al. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease. Int. J. Mol. Sci. 2021, 22, 860

43/100 ✓ Peer-reviewed Drug development International journal of molecular sciences

Key finding: With this notice, the Internation Journal of Molecular Sciences Editorial Office states their awareness of the concerns regarding the integrity of a number of the figures published within this publication [...].

• Treatments
• Brain Biology

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Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges

43/100 ✓ Peer-reviewed Drug development Pharmacological research

Key finding: Patients with T2DM have a higher risk of developing neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), accompanied by more severe motor deficits and faster disease progression, suggesting dysregulation of insulin signaling in these diseases. +4 more findings

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid solutions: lecanemab, gantenerumab, and donanemab in the treatment of Alzheimer's disease

35/100 ✓ Peer-reviewed Treatments The Egyptian Journal of Neurology Psychiatry and Neurosurgery

Key finding: Alzheimer’s disease (AD), the leading cause of dementia, is a multifaceted neurodegenerative disorder characterized by amyloid-beta (Aβ) aggregation, tau pathology, and neuroinflammation. +4 more findings

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Autophagy in alzheimer disease pathogenesis and its therapeutic values

40/100 ✓ Peer-reviewed Inflammation and the immune system Autophagy Reports

Key finding: Autophagy is also believed to be protective in neurodegeneration. +4 more findings

• Brain Biology
• Treatments

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Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses

44/100 ✓ Peer-reviewed Brain tissue and pathology Cells

Key finding: A hallmark of ALS-FTD pathology is the abnormal aggregation of proteins, including Cu/Zn superoxide dismutase (SOD1), transactive response DNA-binding protein 43 (TDP-43), fused in sarcoma/translocated in liposarcoma (FUS/TLS), and dipeptide repeat proteins resulting from C9orf72 hexanucleotide expansions. +4 more findings

• Brain Biology
• Prevention
• Genetics

Full summary, score breakdown and related studies → Original source