Newest studies

Home as mind: AI extenders and affective ecologies in dementia care

37/100 ✓ Peer-reviewed Caregiving Synthese

Key finding: I consider applications of “AI extenders” to dementia care.

• Digital Tools

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Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias

63/100 ✓ Peer-reviewed Risk factors JAMA Internal Medicine

Key finding: The sample included 3 329 977 beneficiaries (2 126 290 [63.9%] female, 33 887 [1.0%] Asian, 354 771 [10.7%] Black, 61 515 [1.8%] Hispanic, 2 831 391 [85.0%] White, and 891 815 [26.8%] dual eligible for Medicaid). +4 more findings

• Care Services
• Health Equity

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Bioaccumulation of microplastics in decedent human brains

64/100 ✓ Peer-reviewed Getting a diagnosis Nature medicine

Key finding: MNPs in these organs primarily consist of polyethylene, with lesser but significant concentrations of other polymers. +3 more findings

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Ultrasound Neuromodulation With Transcranial Pulse Stimulation in Alzheimer Disease: A Randomized Clinical Trial

66/100 ✓ Peer-reviewed Treatments JAMA network open

Key finding: For the intention-to-treat analysis, 60 patients between ages 51 and 82 years (mean [SD], 70.65 [8.16] years; 30 females; 30 males) were included. +4 more findings

• Treatments
• Clinical Trials

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Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity

73/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: The mean (SD) baseline age of 758 participants was 61.5 (6.1) years, and 424 participants [55.9%] were female. +3 more findings

• Biomarkers
• Risk Factors

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A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests

79/100 ✓ Peer-reviewed Biomarkers Brain

Key finding: Plasma %p-tau217WashU had the highest performance, with significantly higher AUCs than all the immunoassays (Pdiff < 0.007). +4 more findings

• Biomarkers

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Network models of late life depression symptoms and cognitive impairments across time

64/100 ✓ Peer-reviewed Risk factors Aging & mental health

Key finding: Across 3544 participants, ≥65 years of age, with no diagnosed dementia-related disorders, the depression symptom everything was an effort showed high expected influence across all time points. +4 more findings

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Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Interquartile range differences in amyloid beta 42/40, percent phosphorylated tau 217 (%p-tau217), and Amyloid Probability Score 2 were associated with 1.29 (P = 0.09), 1.38 (P < 0.001), and 1.20 (P = 0.05) increases, respectively, in the hazard of progression from A- to A+ and 0.27 (P = 0.16), 0.50 (P = 0.007), and 0.28 (P = 0.15) Centiloid/year increases, respectively, in annual rate of amyloid PET change. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Models including plasma biomarkers yielded the most accurate predictions of tau-PET burden (best model: R-squared = 0.66-0.69), with especially high contribution from plasma phosphorylated tau-217 (p-tau217). +4 more findings

• Brain Scans
• Biomarkers
• Digital Tools

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Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: On NULISA, phosphorylated tau (p-tau217, p-tau231, and p-tau181), glial fibrillary acidic protein (GFAP), and microtubule-associated protein tau (MAPT-tau) showed the top significant association with amyloid beta (Aβ) positron emission tomography (PET) status, followed by the neuroinflammation markers C-C motif ligand 2 (CCL2), chitotriosidase 1 (CHIT1) and interleukin-8 (CXCL8), and the synaptic marker neurogranin (NRGN). +4 more findings

• Biomarkers
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic

66/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma p-tau biomarkers had a greater diagnostic performance and larger effect sizes compared to t-tau and Aβ42/40 assays in detecting Aβ pathology. +4 more findings

• Biomarkers
• Diagnosis
• Care Services

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Examining multimorbidity contributors to dementia over time

52/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: Hypertension, acute myocardial infarction, atrial fibrillation, diabetes, heart failure, ischemic heart disease, stroke, and arthritis additively accounted for 71.8% (95% confidence interval [CI]: 62.9%-79.1%) of ADRD incident cases based on LE-AAF. +4 more findings

• Risk Factors

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Lower Retinal Arteriolar Density Is Associated With Higher Cerebral Small Vessel Disease Burden: An Optical Coherence Tomography Angiography Study

40/100 ✓ Peer-reviewed Vascular contributions Brain and Behavior

Key finding: 246 older adults (mean age = 58.84 ± 7.00 years; 38.21 % males) were included in our data analysis. +4 more findings

• Other Dementias

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Protocol for a meta-review of interventions to prevent and manage ICU delirium

54/100 ✓ Peer-reviewed Clinical safety BMJ Open

Key finding: ICU delirium is also associated with increased mortality and dementia in the longer term. +2 more findings

• Prevention

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Impact of frailty status on the effect of a multidomain lifestyle intervention on cognition

52/100 ✓ Peer-reviewed Prevention trials Age and Ageing

Key finding: Frailty status (prefrail/frail n = 520, robust n = 625) at baseline did not modify the effect of intervention on global cognition during the 2-year follow-up (P-value for frailty × intervention × time interaction > .05). +4 more findings

• Lifestyle

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Relationship between Alzheimer's Disease and Type 2 Diabetes: Critical Review On Cellular and Molecular Common Pathogenic Mechanisms

31/100 ✓ Peer-reviewed Disease mechanisms Current Alzheimer Research

Key finding: Both diseases exhibit common genetic, epigenetic, biochemical and physiological characteristics. +4 more findings

• Brain Biology
• Risk Factors

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The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias

38/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: Our findings indicate that the prevention and treatment of vascular health may be a potential target for ADRD combination therapy. +1 more finding

• Brain Biology
• Risk Factors

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Effect of Steroids on the Progression of Alzheimer's Dementia: A Retrospective Chart Review

37/100 ✓ Peer-reviewed Inflammation and the immune system Aging Medicine

Key finding: In our study, steroid use delayed the progression of dementia. +2 more findings

• Brain Biology

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Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression

55/100 ✓ Peer-reviewed Brain tissue and pathology Nature Communications

Key finding: Participants with a prior brain health event are 4% epigenetically older (β = 0.04, SE = 0.01), indicating these conditions are associated with accelerated aging beyond that captured by chronological age. +4 more findings

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Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts

46/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: After controlling for the level of cognitive impairment, we found a double dissociation between AD clinical phenotype and localization/magnitude of atrophy, characterized by predominant neocortical involvement in EOAD and more focal anterior medial temporal involvement in LOAD. +4 more findings

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Perspective: Emerging challenges for a future ADNI

44/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: In the last two decades, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has significantly advanced our understanding, technologies, and methods for detecting and diagnosing Alzheimer's disease and related dementias.

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Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank

46/100 ✓ Peer-reviewed Long-term cohort studies CNS Neuroscience & Therapeutics

Key finding: During a median follow-up of 13.8 years, 6554 (1.9%) cases of incident delirium were documented. +4 more findings

• Lifestyle

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Associations of Mid‐ and Late‐Life Fasting Blood Glucose Levels With Dementia Risk Among Patients With Diabetes: Framingham Heart Study

44/100 ✓ Peer-reviewed Long-term cohort studies European Journal of Neurology

Key finding: Higher FBG level at midlife was not associated with an increased risk of dementia. +4 more findings

• Risk Factors

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Etomidate ameliorates Alzheimer-like neuropathology and cognitive impairment in APP/PS1 mice

26/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

Key finding: In conclusion, etomidate ameliorates Alzheimer-like neuropathology and cognitive impairment in APP/PS1 mice, indicating that etomidate may be a potentially useful drug for the treatment of AD.

• Brain Biology
• Digital Tools

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Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period

44/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: We identified that the APOE4 genotype affected ΔHV in females. +4 more findings

• Genetics
• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source