Home › Research › Prevention trials
Managing Cognitive Decline Through a Social Robot–Based Intervention: Protocol for the engAGE Proof of Concept and Randomized Controlled Trial
Giulio Amabili, Elvira Maranesi, Arianna Margaritini, Anna Rita Bonfigli, Elisa Felici, Federico Barbarossa, Marco Benadduci, Laëtitia Gosetto et al.. JMIR Research Protocols, 2025-06-03
Topic: Risk, prevention and care in population studies
Data collection commenced in November 2023 and finished in July 2024, with the enrollment of 49 older adults with MCI (n=40, 81.6%, assigned to the experimental group [EG] and n=9, 18.4%, to the control group [CG]) conducted from October 2023 to April 2024. Data analysis was concluded in November 2024, and results will be published by 2026. The engAGE PoC represents an innovative study focused on the impact of a technology-based multidomain intervention designed for older adults with MCI that aimed to counteract cognitive decline through cognitive training, as well as improvement in terms of the quality of life, social engagement, physical activity, and sleep quality of primary end users. TRIAL REGISTRATION: ClinicalTrials.gov NCT06302686; https://clinicaltrials.gov/study/NCT06302686. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/67601.
Key findings
- Data collection commenced in November 2023 and finished in July 2024, with the enrollment of 49 older adults with MCI (n=40, 81.6%, assigned to the experimental group [EG] and n=9, 18.4%, to the control group [CG]) conducted from October 2023 to April 2024.
- Data analysis was concluded in November 2024, and results will be published by 2026.
- The engAGE PoC represents an innovative study focused on the impact of a technology-based multidomain intervention designed for older adults with MCI that aimed to counteract cognitive decline through cognitive training, as well as improvement in terms of the quality of life, social engagement, physical activity, and sleep quality of primary end users.
- TRIAL REGISTRATION: ClinicalTrials.gov NCT06302686; https://clinicaltrials.gov/study/NCT06302686.
- INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/67601.
Why it matters
This is a protocol describing a social robot-based intervention for older adults with mild cognitive impairment, with results not yet published. No conclusions about treating, curing, or preventing Alzheimer's disease can be drawn from it.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designrandomized controlled trial
- Participants40
- Effect size81.6%; 18.4%
- Evidence strengthHigh
How this study scored 59/100
Published in a peer-reviewed journal, and it is a randomised controlled trial.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (JMIR Research Protocols) |
| Journal's citation record | 0 / 4 | JMIR Research Protocols: journal h-index 62 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 40 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Roberta Bevilacqua: h-index 24 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University Hospital of Geneva: institution h-index 635 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40896828) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Amabili, G., Maranesi, E., Margaritini, A., Bonfigli, A. R., Felici, E., Barbarossa, F., et al. (2025). Managing Cognitive Decline Through a Social Robot–Based Intervention: Protocol for the engAGE Proof of Concept and Randomized Controlled Trial. JMIR Research Protocols. https://doi.org/10.2196/67601
Vancouver
Amabili G, Maranesi E, Margaritini A, Bonfigli AR, Felici E, Barbarossa F, et al. Managing Cognitive Decline Through a Social Robot–Based Intervention: Protocol for the engAGE Proof of Concept and Randomized Controlled Trial. JMIR Research Protocols. 2025. doi:10.2196/67601. PMID: 40896828.
BibTeX
@article{amabili2025-40896828,
author = {Amabili, Giulio and Maranesi, Elvira and Margaritini, Arianna and Bonfigli, Anna Rita and Felici, Elisa and Barbarossa, Federico and Benadduci, Marco and Gosetto, Laëtitia and others},
title = {{Managing Cognitive Decline Through a Social Robot–Based Intervention: Protocol for the engAGE Proof of Concept and Randomized Controlled Trial}},
journal = {JMIR Research Protocols},
year = {2025},
doi = {10.2196/67601},
pmid = {40896828},
url = {https://doi.org/10.2196/67601}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.