Newest studies

Effects of regional white matter hyperintensities and β-amyloid on domain-specific cognition and progression to dementia

40/100 ✓ Peer-reviewed Vascular contributions Brain and Cognition

Key finding: White matter hyperintensities (WMHs) and cerebral β-amyloid (Aβ) have been characterized as clinically significant biomarkers associated with greater cognitive decline and incidence of Alzheimer's Disease (AD) dementia. +2 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Determinants of Mortality and Causes of Death in Patients With Dementia and Very Severe Challenging Behavior

45/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: Of the 127 participants, one-third died during their stay. +4 more findings

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Quantification of Alzheimer disease neuropathology using tissue microarrays

39/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuropathology & Experimental Neurology

Key finding: The results demonstrated that 2 mm cores differentiated AD-affected individuals from healthy donors. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment due to cerebrovascular disease and Alzheimer’s

31/100 ✓ Peer-reviewed Mild cognitive impairment Neurology neuropsychiatry Psychosomatics

Key finding: For several years before dementia develops, it is often preceded by mild cognitive impairment (MCI), which is characterized by reduced memory and/or other cognitive functions without significant decline in daily activities. +2 more findings

• Early Stage
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia

40/100 ✓ Peer-reviewed Lewy body dementia Cell Reports

Key finding: Here, we assess mRNA nucleocytoplasmic localization by performing transcriptome-wide profiling on nuclear and cytoplasmic fractions of human iPSC-derived cortical neurons from healthy individuals compared to those with familial AD or FTD. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study

53/100 ✓ Peer-reviewed How common it is Journal of Alzheimer s Disease

Key finding: We show that semaglutide was associated with a significantly reduced risk of overall ADRD incidence with a hazard ratio ranging from 0.54 (0.49-0.59) compared with insulin, 0.67 (0.61-0.74) compared with metformin, to 0.80 (0.72-0.89) compared with older generation glucagon-like peptide-1 agonists (GLP-1RAs). +3 more findings

• Risk Factors
• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Caring for loved ones as community: Supporting caregivers of Native Hawaiians living with dementia

32/100 ✓ Peer-reviewed Caregiving SSM - Mental Health

Key finding: Caring as a community was a common theme. +4 more findings

• Caregiving

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Anti-Amyloid Aggregation Effects of Gobaishi (Galla chinensis) and Its Active Constituents

39/100 ✓ Peer-reviewed Treatments Molecules

Key finding: Evaluation of their anti-Aβ aggregation effects revealed that PGG and MG contribute 1.5% and 0.7% of the activity of Gobaishi, respectively. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Dementia in ancient Greece and Rome

43/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: Texts from the Roman era with references to elderly memory loss did not have any earlier Greek counterpart, suggesting historically novel environmental and lifestyle factors in dementia that are associated with the modern dementia epidemic.

Full summary, score breakdown and related studies → Original source

Donanemab: The dawn of disease-modifying treatment for Alzheimer's disease in Australia

43/100 ✓ Peer-reviewed Treatments Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

Key finding: The roll-out of disease-modifying treatment comes with significant challenges but also provides a unique opportunity to improve care for people with AD and other dementias.

• Treatments

Full summary, score breakdown and related studies → Original source

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

43/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: HT was associated with increased CSF α-klotho levels. +3 more findings

• Biomarkers

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BRAIN-Diabetes: a randomised trial to test the feasibility of an adapted FINGER multidomain intervention in adults with type 2 diabetes living in rural border regions of Ireland

52/100 ✓ Peer-reviewed Prevention trials European Journal of Ageing

Key finding: In total, 156 individuals were assessed for eligibility, and 79 (51%) were recruited (mean age 61.6 ± 6.9 (range 60-75) years; 68% male). +4 more findings

• Clinical Trials
• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology Study

61/100 ✓ Peer-reviewed Lewy body dementia Movement Disorders

Key finding: The LBD-present group had higher QSM values in the SNc (P = 0.008) than the LBD-absent group with no differences in SNr. +4 more findings

• Brain Scans
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants

50/100 ✓ Peer-reviewed Lewy body dementia Acta Neuropathologica

Key finding: However, preanalytical and analytical factors significantly affect these parameters, reducing reproducibility. +4 more findings

• Brain Biology
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Exploring Factors Related to Social Isolation Among Older Adults in the Predementia Stage Using Ecological Momentary Assessments and Actigraphy: Machine Learning Approach

42/100 ✓ Peer-reviewed Digital health tools Journal of Medical Internet Research

Key finding: Of the 99 participants, 43 were classified into the low social interaction frequency group, and 37 were classified into the high loneliness level group. +4 more findings

• Digital Tools
• Lifestyle

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Epidemiology of oral health in older adults aged 65 or over: prevalence, risk factors and prevention

46/100 ✓ Peer-reviewed Prevention and risk Aging Clinical and Experimental Research

Key finding: According to the global multi-country epidemiological survey and the WHO report, the prevalence of oral diseases in the elderly aged 65 and above showed a significant increase, and the burden of disease was concentrated on dental caries, periodontal disease and tooth loss.

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Mechanisms of interventions targeting modifiable factors for dementia risk reduction

47/100 ✓ Peer-reviewed Prevention and risk Molecular Neurodegeneration

Key finding: The findings of this review underscore the potential of lifestyle-based interventions in modulating several different types of pathophysiological pathways associated with dementia.

• Prevention
• Risk Factors
• Biomarkers

Full summary, score breakdown and related studies → Original source

APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban

58/100 ✓ Peer-reviewed Genetics JAMA Neurology

Key finding: Of 413 477 All of Us participants, 2038 were eligible. +4 more findings

• Genetics
• Treatments

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Meta-Analysis Reveals Consistently Positive Effects of Dementia Caregiver Interventions on Psychological Distress

41/100 ✓ Peer-reviewed Caregiving Dementia and Geriatric Cognitive Disorders

Key finding: These findings highlight the importance of tailoring interventions to caregiver characteristics and outcome type. +4 more findings

• Caregiving

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Comparison of the diagnostic accuracy of five cross-cultural cognitive screening instruments for dementia and mild cognitive impairment in a multicultural memory clinic sample

53/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: Receiver operating characteristic curve (ROC) analysis was used to examine diagnostic accuracy for dementia and MCI as compared to specialist diagnosis. +1 more finding

• Diagnosis
• Early Stage
• Care Services

Full summary, score breakdown and related studies → Original source

Prevalence, timing and characteristics of delirium preceding dementia with Lewy bodies: a retrospective case series

36/100 ✓ Peer-reviewed Clinical safety Journal of Neurology

Key finding: 26% of the participants experienced delirium prior to diagnosis of DLB, with one participant experiencing multiple episodes in the 24 months before diagnosis. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Evaluation of preanalytical factors on quantification of amyloid-β (1-42), phosphorylated tau 181, and total tau in cerebrospinal fluid

31/100 ✓ Peer-reviewed Tau biomarkers Laboratory Medicine

Key finding: For all 3 analytes, less than 10% difference was observed between the concentrations measured on day 0 and after 14 days of transportation and refrigeration. +2 more findings

• Biomarkers

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Dissecting the Interactions of Diabetes Mellitus and Hearing Loss with Cognitive Decline and Dementia

36/100 ✓ Peer-reviewed Risk factors Brain Sciences

Key finding: The aging population is increasingly affected by both diabetes mellitus and hearing loss, two conditions that often coexist and can significantly impact quality of life.

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Artificial Intelligence in the Diagnostic Use of Transcranial Doppler and Sonography: A Scoping Review of Current Applications and Future Directions

45/100 ✓ Peer-reviewed Digital health tools Bioengineering

Key finding: Despite promising advances, significant challenges remain, including data standardization, algorithm interpretability, and the integration of these tools into clinical practice. +1 more finding

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Plasma p-tau217 predicting brain-wide tau accumulation in preclinical AD

63/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Plasma p-tau217 was associated with concurrent Aβ in most cortical regions and tau in temporo-parietal cortices. +2 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source