Newest studies

Genetic background and multidomain interventions in mild cognitive impairment

40/100 ✓ Peer-reviewed Prevention trials Alzheimer s Research & Therapy

Key finding: Although the partial efficacy of multidomain interventions for dementia prevention has been demonstrated, understanding the characteristics of individuals who benefit most from these interventions is crucial for optimizing resource allocation. +3 more findings

• Genetics
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Comprehensive Anatomical Staging Predicts Clinical Progression in Mild Cognitive Impairment: A Data-Driven Approach

41/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: Alzheimer’s disease (AD) presents significant challenges in clinical practice due to its heterogeneous manifestation and variable progression rates. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Evaluating EEG complexity and spectral signatures in Alzheimer’s disease and frontotemporal dementia: evidence for rostrocaudal asymmetry

39/100 ✓ Peer-reviewed Lewy body dementia npj Aging

Key finding: In contrast, fractal dimension and long-range temporal correlations (LRTCs) revealed distinct topographical differences: AD exhibited rostral dominance in fractal dimension, whereas FTD showed caudal dominance. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Regional Differences in Dementia Incidence Among US Veterans

54/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: Among the 1 268 599 participants (mean age, 73.9 [SD, 6.1] years; n = 25 335 [2%] female), dementia incidence rates per 1000 person-years were lowest in the Mid-Atlantic (11.2; 95% CI, 11.1-11.4) and highest in the Southeast (14.0; 95% CI, 13.8-14.2). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Dementia in Sub-Saharan Africa: Risk factors, public perception, and management approaches

41/100 ✓ Peer-reviewed Prevention and risk Journal of Medicine Surgery and Public Health

Key finding: Incidence figures are also weak and mostly restricted to a few countries, thus potentially underestimating the true regional burden. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Brain tau PET-based identification and characterization of subpopulations in patients with Alzheimer’s disease using deep learning-derived saliency maps

44/100 ✓ Peer-reviewed Genetics EJNMMI Physics

Key finding: Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder in which tau neurofibrillary tangles are a pathological hallmark closely associated with cognitive dysfunction and neurodegeneration. +4 more findings

• Brain Scans
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Active Travel Mode and Incident Dementia and Brain Structure

57/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: The study encompassed 479 723 participants (mean [SD] age, 56.5 [8.1] years; 260 730 females [54.4%]), including 271 690 in the YOD analyses and 334 939 in the LOD analyses. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Prediction Of Alzheimer Patients with Machine Learning Algorithms

28/100 ✓ Peer-reviewed Genetics Indonesian Journal of Computer Science

Key finding: The results indicate that the Random Forest algorithm with Transformer methods achieved the highest accuracy of 98.9%. +1 more finding

• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

White Matter Abnormalities and Cognition in Aging and Alzheimer Disease

70/100 ✓ Peer-reviewed Genetics JAMA Neurology

Key finding: Of 4467 participants who underwent 9208 longitudinal cognitive sessions, 2698 (60.4%) were female, and the mean age (SD) was 74.3 (9.2) years; 3213 were cognitively unimpaired, 972 had mild cognitive impairment, and 282 had AD dementia. +1 more finding

Full summary, score breakdown and related studies → Original source

Antiamyloid treatment for dementia: concerns outweigh hopes

35/100 ✓ Peer-reviewed Drug development Current opinion in psychiatry

Key finding: Recent findings There is an association, but Alzheimer pathology explains less than 40% of the attributable risk of dementia when other pathologies such as vascular, Lewy Body and TDP-43 are accounted. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Estimation of the value-based price of a blood test for Alzheimer's disease pathology in primary and specialty care in the U.S

45/100 ✓ Peer-reviewed Costs and economics Journal of Prevention of Alzheimer's Disease

Key finding: The results project substantial cost savings from implementing a blood test for AD pathology within the diagnostic pathway based on modeling results, which future research should confirm with actual data. +3 more findings

• Biomarkers
• Policy

Full summary, score breakdown and related studies → Original source

Metformin protects against insulin resistance-related dementia risk involving restored microglial homeostasis

39/100 ✓ Peer-reviewed Inflammation and the immune system Life sciences

Key finding: Our findings suggest that metformin exerts therapeutic effects beyond glycemic control in the context of T2D. By mitigating neuroinflammation and modulating microglial autophagy, metformin emerges as a promising therapeutic agent for cognitive decline associated with diabetes and potentially other neurological disorders. +3 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

A rapid scoping review on operationalizing cognitive and social activities in research on dementia risk reduction

37/100 ✓ Peer-reviewed Prevention trials Aging & Mental Health

Key finding: Across 58 studies, 38 had an observational design and predominantly used questionnaires to measure cognitive and social activities. +4 more findings

• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation

43/100 ✓ Peer-reviewed Inflammation and the immune system Phytomedicine : international journal of phytotherapy and phytopharmacology

Key finding: Our results demonstrate CA effectively inhibits NLRP3 inflammasome activation, reduces microglial pyroptosis, and mitigates oxidative stress-induced mitochondrial impairment in BV-2 cells. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma biomarkers for early detection of alzheimer's disease: a cross-sectional study in a Japanese cohort

54/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Sixty-nine HC, 13 preclinical AD, 38 AD-MCI, 44 AD-D, and 79 non-AD CI participants were included. +4 more findings

• Biomarkers
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

The continuous learning needs of personal support workers who care for people living with dementia in long-term care

37/100 ✓ Peer-reviewed Clinical safety Educational Gerontology

Key finding: Personal support workers (PSWs) in long-term care (LTC) homes provide the most care to people living with dementia, yet receive the least education compared to other healthcare professionals.

• Care Services

Full summary, score breakdown and related studies → Original source

Impact of Glucagon‐Like Peptide‐1 Receptor Agonists on the Dementia Incidence in Patients With Type 2 Diabetes Mellitus: A Population‐Based Longitudinal Cohort Study

47/100 ✓ Peer-reviewed How common it is Diabetes/Metabolism Research and Reviews

Key finding: Among a cohort comprising 109,778 individuals, the use of GLP-1RA demonstrated a reduced risk of dementia compared with its non-use (aHR, 0.90; 95% CI, 0.83-0.97). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Ambulatory Care Sensitive Hospitalizations and Disparities Among Older Adults With Dementia Before and During the Pandemic

38/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: The study included 2.35 million beneficiaries in 2019 and 1.85 million in 2021. +4 more findings

• Health Equity
• Care Services

Full summary, score breakdown and related studies → Original source

Bridging the gap: A conversion framework for CDR-SB and MoCA scores in Alzheimer's disease and related dementia

49/100 ✓ Peer-reviewed Getting a diagnosis The Journal of Prevention of Alzheimer s Disease

Key finding: CDR-SB and MoCA scores showed strong inverse correlation (Spearman's ρ = -0.68; p < 0.001). +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Microglia-derived extracellular vesicles mediate fine particulate matter-induced Alzheimer's disease-like behaviors through the miR-34a-5p/DUSP10/p-p38 MAPK pathway

43/100 ✓ Peer-reviewed Risk factors Journal of hazardous materials

Key finding: Fine particulate matter (PM2.5), a major component of air pollution, poses significant global health risks. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma and MRI biomarkers capture neuronal damage in former professional boxers

66/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: We evaluated blood-based biomarkers for neurodegeneration and Alzheimer's Disease (AD) pathology, clinical features, and MRI biomarkers in former professional boxers compared to patients with AD or patients with subjective cognitive decline (SCD). +2 more findings

• Biomarkers
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Communicating palliative hope in late-stage dementia: thematic analysis of hope work in care plan meetings with nursing home residents’ families

37/100 ✓ Peer-reviewed Brain tissue and pathology The Journals of Gerontology Series B

Key finding: We identified three main themes of palliative hope in late-stage dementia: 1) Life is good and there is still time, 2) Agency and identity are not lost, and 3) Death will be good and professional support is available. +4 more findings

• End-of-Life Care
• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

The patient pathway for mild cognitive impairment due to Alzheimer’s disease in Asia: Current practices, barriers, and expert recommendations for optimization

42/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of Prevention of Alzheimer s Disease

Key finding: Forty-four physicians, primarily neurologists (n = 31; 70.5 %), were interviewed. +4 more findings

• Early Stage
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Readability of AI-Generated Patient Information Leaflets on Alzheimer’s, Vascular Dementia, and Delirium

41/100 ✓ Peer-reviewed Lewy body dementia Cureus

Key finding: There are meaningful differences in the readability of patient information generated by different large language models. +3 more findings

• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source

Training for dementia care and support in rural and remote Australia: appraisals from a nationwide workforce survey

41/100 ✓ Peer-reviewed Disparities BMC Geriatrics

Key finding: There were 558 respondents from residential aged care, community/primary care and hospital settings across all Australian states and territories. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source