Newest studies

Characterizing dysregulations via cell-cell communications in Alzheimer's brains using single-cell transcriptomes

43/100 ✓ Peer-reviewed Genetics BMC neuroscience

Key finding: Specifically, we first performed broad communication pattern analyses to highlight that biologically related cell types in normal brains rely on largely overlapping signaling networks and that the AD brain exhibits the irregular inter-mixing of cell types and signaling pathways. +4 more findings

• Genetics
• Brain Biology

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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

48/100 ✓ Peer-reviewed Treatments Scientific reports

Key finding: Marked differences in Aβ antibody binding to CAA fibrils were observed. +4 more findings

• Side Effects
• Brain Biology
• Treatments

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Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank

69/100 ✓ Peer-reviewed Long-term cohort studies BMC medicine

Key finding: Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) are sensitive markers of neuroinflammation and neuronal damage. +3 more findings

• Biomarkers

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Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing

56/100 ✓ Peer-reviewed Prevention and risk Age and ageing

Key finding: Increased plasma lycopene concentrations (OR [95% CI] = 1.07 [1.01, 1.14]), higher red meat (OR [95% CI] = 1.10 [1.03, 1.19]), and lower poultry consumption (OR [95% CI] = 0.93 [0.87, 0.99]) were associated with an increased risk for AD in individuals with a neurogenesis-centred susceptibility. +1 more finding

• Lifestyle

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Metformin mitigates dementia risk among individuals with type 2 diabetes

63/100 ✓ Peer-reviewed Drug development Clinical diabetes and endocrinology

Key finding: However, the review shows the complex nature of these outcomes, revealing variations in results in some studies.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology

61/100 ✓ Peer-reviewed Biomarkers Dementia and geriatric cognitive disorders extra

Key finding: Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (odds ratio [OR] = 2.65, p = 0.005). +3 more findings

• Biomarkers

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Racial/Ethnic Disparities in Hospital Readmission and Frequent Hospitalizations Among Medicare Beneficiaries With Alzheimer’s Disease and Related Dementia: Traditional Medicare Versus Medicare Advantage

54/100 ✓ Peer-reviewed Health systems and care delivery The Journals of Gerontology Series B

Key finding: TM was associated with higher odds of 30-day readmission (OR = 1.07 [CI: 1.02 to 1.12]) and frequent hospitalizations (OR = 1.10 [CI: 1.06 to 1.14]) compared to MA. +4 more findings

• Care Services
• Health Equity

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Updated safety results from phase 3 lecanemab study in early Alzheimer's disease

78/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Overall, 1795 participants from Core and 1612 participants with at least one dose of lecanemab (Core + OLE) were included.

• Treatments
• Clinical Trials

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Incorporating advance care planning in dementia care

43/100 ✓ Peer-reviewed End-of-life care Nursing older people

Key finding: Recent policy focus in dementia care has been on living well with the condition; however, being able to die well with dementia is of equal importance. +3 more findings

• End-of-Life Care

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Alzheimer-like behavior and synaptic dysfunction in 3 × Tg-AD mice are reversed with calcineurin inhibition

43/100 ✓ Peer-reviewed Disease mechanisms Experimental brain research

Key finding: The results showed that FK506 treatment ameliorated cognitive deficits, as indicated by the decreased latency in the water maze, and attenuated tau hyperphosphorylation in 3 × Tg-AD mice. +1 more finding

• Brain Biology

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Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies

54/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica communications

Key finding: Morphologically, reactive and amoeboid microglia were common in mixed DLB + AD, while homeostatic microglia with a small soma and thin processes were observed in pure DLB cases. +4 more findings

• Brain Biology
• Other Dementias

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Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential

43/100 ✓ Peer-reviewed Disease mechanisms Aging and disease

Key finding: An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the gut microbiota. +4 more findings

• Treatments
• Brain Biology

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Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study

43/100 ✓ Peer-reviewed Tau biomarkers Journal of affective disorders

Key finding: The synaptic proteins revealed no statistically significant differences between BD and HC, neither at baseline, one-year follow-up, or in terms of changes from baseline to follow-up. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Clinical Evidence for GLP-1 Receptor Agonists in Alzheimer's Disease: A Systematic Review

83/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease reports

Key finding: GLP-1 RA therapy did not alter amyloid-β and tau biomarkers nor show improvements in cognition but showed potential metabolic and neuroprotective benefits.

• Treatments

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APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease

69/100 ✓ Peer-reviewed How common it is Nature medicine

Key finding: This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. +1 more finding

• Genetics

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Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model

55/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of disease

Key finding: The increased dosage of genes on HSA21 is associated with early neurodevelopmental changes and subsequently at adult age with the development of Alzheimer-like cognitive decline. +1 more finding

• Down Syndrome
• Brain Biology

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Soluble receptor of advanced glycation end product as a biomarker in neurocognitive and neuropsychiatric disorders: A meta-analysis of controlled studies

56/100 ✓ Peer-reviewed Disease mechanisms European journal of clinical investigation

Key finding: This meta-analysis revealed a significant reduction in sRAGE in neurocognitive and neuropsychiatric disorders particularly in Asians and moderate age. +3 more findings

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Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles

71/100 ✓ Peer-reviewed Biomarkers Brain

Key finding: The main findings demonstrated an association between serum GFAP level and post-mortem tau pathology (β = 12.85; P < 0.001) that was independent of amyloid deposits (β = 13.23; P = 0.02). +4 more findings

• Brain Biology
• Biomarkers

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Dietary factors and Alzheimer's disease risk: a Mendelian randomization study

43/100 ✓ Peer-reviewed Genetics European journal of medical research

Key finding: The MR analysis conducted in this study found no statistically significant causal association between 20 dietary habits and the risk of AD (All p > 0.05). +3 more findings

• Lifestyle

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Three major effects of APOE ε4 on Aβ immunotherapy induced ARIA

45/100 ✓ Peer-reviewed Treatments Frontiers in aging neuroscience

Key finding: The two categories of ARIA are of major concern for patients, families, and prescribing physicians, with ARIA-E presenting as cerebral edema, and ARIA-H as cerebral hemorrhages (micro- and macro-). +4 more findings

• Side Effects
• Genetics
• Brain Biology

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Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report

47/100 ✓ Peer-reviewed TREM2 and immune genetics Arteriosclerosis, thrombosis, and vascular biology

Key finding: Trem2 (triggering receptor on myeloid cells 2), a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell survival, proliferation, and anti-inflammatory responses. +3 more findings

• Genetics
• Brain Biology

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The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact

57/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs. +4 more findings

• Health Equity
• Diagnosis

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Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease

52/100 ✓ Peer-reviewed Biomarkers Autophagy

Key finding: This study reveals mitophagy impairment reflected in biofluid biomarkers of individuals with AD and associated with more advanced AD pathology.

• Biomarkers
• Early Stage
• Brain Biology

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Reserve, resilience and maintenance of episodic memory and other cognitive functions in aging

54/100 ✓ Peer-reviewed Risk factors Neurobiology of aging

Key finding: We found no evidence for the associations of brain reserve or brain maintenance on memory change. +2 more findings

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Sleep Disorders and Cognitive Aging Among Cognitively Impaired Versus Unimpaired Older Adults

54/100 ✓ Peer-reviewed Risk factors The Gerontologist

Key finding: In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b = 0.65, 95% confidence interval [95% CI] = [0.07, 1.23]) and less decline in GCA over time (b = 0.06, 95% CI = [0.001, 0.12]). +4 more findings

• Lifestyle

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