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BIOCHEMICAL MARKERS FOR EARLY DETECTION OF DEMENTIA: A REVIEW OF CURRENT ADVANCES
Giovana Barraboni Cabrini, Paula Schoen, Elisabeth Dotti Consolo, Carolina Gonçalves. Asclepius International Journal of Scientific Health Science, 2025-06-05
Topic: Amyloid, tau and blood-test diagnosis
Recent studies highlight the significance of plasma phosphorylated tau proteins, neurofilament light chain, and amyloid-beta ratios as reliable biomarkers. These markers have demonstrated high sensitivity and specificity in detecting early pathological changes associated with dementia. Advancements in biochemical markers offer promising avenues for early dementia detection. Integrating these biomarkers into clinical practice could enhance diagnostic accuracy and patient outcomes.
Key findings
- Recent studies highlight the significance of plasma phosphorylated tau proteins, neurofilament light chain, and amyloid-beta ratios as reliable biomarkers.
- These markers have demonstrated high sensitivity and specificity in detecting early pathological changes associated with dementia.
- Advancements in biochemical markers offer promising avenues for early dementia detection.
- Integrating these biomarkers into clinical practice could enhance diagnostic accuracy and patient outcomes.
Why it matters
This review states that blood markers such as phosphorylated tau, neurofilament light chain, and amyloid-beta ratios show high sensitivity and specificity for early detection of dementia. These markers may improve diagnosis, but the review does not report any treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 29/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 28 of the 96 points we could judge it on, which is 29 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Asclepius International Journal of Scientific Health Science) |
| Journal's citation record | 0 / 4 | Asclepius International Journal of Scientific Health Science: journal h-index 2 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | Faculdade de Ciências Médicas da Santa Casa de São Paulo: institution h-index 147 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 28 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 28 of the 96 points we could judge it on is 29 out of 100. |
| Total | 29 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.70779/aijshs.v4i6.142
- Original source →
- Free full text: Asclepius International Journal of Scientific Health Science →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Cabrini, G. B., Schoen, P., Consolo, E. D., & Gonçalves, C. (2025). BIOCHEMICAL MARKERS FOR EARLY DETECTION OF DEMENTIA: A REVIEW OF CURRENT ADVANCES. Asclepius International Journal of Scientific Health Science. https://doi.org/10.70779/aijshs.v4i6.142
Vancouver
Cabrini GB, Schoen P, Consolo ED, Gonçalves C. BIOCHEMICAL MARKERS FOR EARLY DETECTION OF DEMENTIA: A REVIEW OF CURRENT ADVANCES. Asclepius International Journal of Scientific Health Science. 2025. doi:10.70779/aijshs.v4i6.142.
BibTeX
@article{cabrini2025-65e9c8f8,
author = {Cabrini, Giovana Barraboni and Schoen, Paula and Consolo, Elisabeth Dotti and Gonçalves, Carolina},
title = {{BIOCHEMICAL MARKERS FOR EARLY DETECTION OF DEMENTIA: A REVIEW OF CURRENT ADVANCES}},
journal = {Asclepius International Journal of Scientific Health Science},
year = {2025},
doi = {10.70779/aijshs.v4i6.142},
url = {https://doi.org/10.70779/aijshs.v4i6.142}
}
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