This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

51/100

✓ Peer-reviewed alzhub usefulness score 51 out of 100. Inflammation and the immune system

Topic: Amyloid, tau and blood-test diagnosis

Currently, ample evidence has shown that inflammasomes are closely related to the occurrence and development of Alzheimer's disease. Results A total of 1,128 publications related to the inflammasome in Alzheimer's disease were recorded in the WoSCC, comprising 738 articles and 390 reviews. Keyword analysis showed that nlrp3 inflammasome, neuroinflammation, microglia activation, and amyloid-beta were the most common terms, reflecting the main research interests in currently published papers in this field. Research in this field primarily focuses on the NLRP3 inflammasome, which is closely associated with pathological products like Aβ and tau proteins.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Chen, Y., Pei, H., Li, H., Zeng, W., & Li, Z. (2025). Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis. Frontiers in neurology. https://doi.org/10.3389/fneur.2025.1540083

Vancouver

Chen Y, Pei H, Li H, Zeng W, Li Z. Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis. Frontiers in neurology. 2025. doi:10.3389/fneur.2025.1540083. PMID: 40538660.

BibTeX

@article{chen2025-40538660,
  author  = {Chen, Y. and Pei, H. and Li, H. and Zeng, W. and Li, Z.},
  title   = {{Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis}},
  journal = {Frontiers in neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1540083},
  pmid    = {40538660},
  url     = {https://doi.org/10.3389/fneur.2025.1540083}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

Key findings

Currently, ample evidence has shown that inflammasomes are closely related to the occurrence and development of Alzheimer's disease.
Results A total of 1,128 publications related to the inflammasome in Alzheimer's disease were recorded in the WoSCC, comprising 738 articles and 390 reviews.
Keyword analysis showed that nlrp3 inflammasome, neuroinflammation, microglia activation, and amyloid-beta were the most common terms, reflecting the main research interests in currently published papers in this field.
Research in this field primarily focuses on the NLRP3 inflammasome, which is closely associated with pathological products like Aβ and tau proteins.

Why it matters

This bibliometric analysis counted 1,128 publications on inflammasomes, protein complexes that trigger inflammation, in Alzheimer's disease. Most research centers on the NLRP3 inflammasome and its close ties to Aβ and tau proteins, with microglia activation and neuroinflammation as common themes. It maps research activity rather than reporting new treatment results.

Study details

Study designsystematic review
Participants464
Evidence strengthLow

How this study scored 51/100

Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for effect reported because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 49 of the 96 points we could judge it on, which is 51 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in neurology)
Journal's citation record	2 / 4	Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29)
Study design	12 / 12	A systematic review of all the studies on the question
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	464 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	A review of other studies — randomization is not credited here
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Zhitao Li holds only 5 work(s), too few to judge a track record — left out of this score
Institution's track record	0 / 3	China Academy of Chinese Medical Sciences: institution h-index 304 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40538660)
Free to read	2 / 2	Free to read
Points	49 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 49 of the 96 points we could judge it on is 51 out of 100.
Total	51 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Inflammation and the immune system

Also in Inflammation and the immune system

138 studies in the library are filed under Inflammation and the immune system with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Inflammation and the immune system hub.

Similar studies

More on Inflammation and the immune system

See all studies in Inflammation and the immune system →