Newest studies

Plasma p-tau217 and APOE genotype: Prodromal Alzheimer's disease staging

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Plasma p-tau217 was 57% higher in subjects with at least one APOE ε4 allele, increased with age, was higher in males, and negatively correlated with brain volume measures by magnetic resonance imaging. +3 more findings

• Biomarkers
• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosis

43/100 ✓ Peer-reviewed Brain tissue and pathology Brain

Key finding: Here, we show that cofilin is hyper-phosphorylated in human ALS and disease models compared to controls. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

DCPS modulates TDP-43-linked neurodegeneration through P-body-mediated RNA decay

45/100 ✓ Peer-reviewed Brain tissue and pathology Neuron

Key finding: Our findings reveal that TDP-43 LOF leads to aberrant mRNA degradation via dysregulating the properties and activity of processing bodies (P-bodies). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

PI-NIP: Protocolo Neuro-Imune de Precisão para Alzheimer baseado em razão IL-6/IL-10 e estimulação 40Hz/10Hz

41/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: Perspectivas futuras O mesmo princípio de modulação glial pode ser aplicado em cenários de morte clínica (parada cardiorrespiratória). +4 more findings

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PI-NIP: Protocolo Neuro-Imune de Precisão para Alzheimer baseado em razão IL-6/IL-10 e estimulação 40Hz/10Hz

29/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: Perspectivas futuras O mesmo princípio de modulação glial pode ser aplicado em cenários de morte clínica (parada cardiorrespiratória). +4 more findings

Full summary, score breakdown and related studies → Original source

The Amyloid Plaque Proteomes of Alzheimer’s Disease and Mild Cognitive Impairment

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's Research Square

Key finding: We identified differentially abundant proteins with robust differences at a false discovery rate (FDR) < 5% and fold-change > 1.5 for 135 proteins in MCI and 156 in AD plaque tissue compared to neighboring non-plaque tissue, which included proteins described previously as well as novel proteins. +3 more findings

• Brain Biology
• Early Stage

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Early Binding of Anti-Amyloid Antibodies to CAA Drives Complement Activation, Inflammation and ARIA in Mice

41/100 ✓ Peer-reviewed Treatments Molecular neurodegeneration

Key finding: Weekly short-term immunization over 7 weeks resulted in elevated CAA- and plaque-associated complement deposition, red blood cell extravasation and microhemorrhages, and was accompanied by significant transcriptomic changes in genes related to complement, inflammation, vascular dysfunction, and endothelial lipid responses. +2 more findings

• Treatments
• Brain Biology
• Side Effects

Full summary, score breakdown and related studies → Original source

Additional file 1 of Quality of end-of-life care among individuals with and without dementia: a Swedish registry-based study

31/100 ✓ Peer-reviewed End-of-life care Figshare

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Additional file 1 of Quality of end-of-life care among individuals with and without dementia: a Swedish registry-based study

41/100 ✓ Peer-reviewed End-of-life care Figshare

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Quality of end-of-life care among individuals with and without dementia: a Swedish registry-based study

36/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: Individuals with dementia were more likely to have staff or family members present at death, to receive documented decisions to shift to EOL care, have symptom assessments made the final week of life and prescription of injectables. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Pyk2 plays a critical role in synaptic dysfunction during the early stages of Alzheimer’s disease

32/100 ✓ Peer-reviewed Disease mechanisms Molecular Neurodegeneration Advances

Key finding: The locus of the gene PTK2B encoding the tyrosine kinase Pyk2 has been associated with the risk of late-onset Alzheimer’s disease, the predominant form of dementia. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Resource-stratified machine learning framework for cognitive status classification and mild cognitive impairment to dementia progression prediction

46/100 ✓ Peer-reviewed Digital health tools Alzheimer s Research & Therapy

Key finding: The Level 3 model achieved high classification performance (AUC: 93.98%), and the Level 1 model achieved comparable performance (AUC: 91.53%). +4 more findings

• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Additional file 1 of National trends in the prevalence of dementia in Medicare Advantage and Traditional Medicare

41/100 ✓ Peer-reviewed Health systems and care delivery Figshare

Full summary, score breakdown and related studies → Original source

Additional file 1 of National trends in the prevalence of dementia in Medicare Advantage and Traditional Medicare

33/100 ✓ Peer-reviewed Health systems and care delivery Figshare

Full summary, score breakdown and related studies → Original source

HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease

48/100 ✓ Peer-reviewed Inflammation and the immune system Brain : a journal of neurology

Key finding: Transcriptomic profiling further revealed downregulation of disease-associated microglial and neurotoxic astrocyte signatures alongside enrichment of synaptic pathways. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

TREM2 in neurodegeneration and diseases

48/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular psychiatry

Key finding: TREM2-initiated signaling plays a crucial role in regulating neuroinflammation and neurodegeneration, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), through the activation of downstream signaling pathways and transcriptional regulation of relevant genes. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

RNA-binding proteins TDP-43 and FUS promote R-loop resolution and regulate transcription termination

41/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Biological Chemistry

Key finding: We have previously demonstrated the role of symmetrical dimethylation (me2s) of a conserved arginine residue (R1810 in human POLR2A) in the C-terminal domain (CTD) of RNA polymerase II (RNAPII), which facilitates the recruitment of the Tudor domain-containing protein SMN to resolve R-loops at transcriptional termination sites. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Prevalence and clinical effects of Lewy Body pathology in non-prion rapidly progressive dementias: a retrospective cohort study

49/100 ✓ Peer-reviewed How common it is Alzheimer s Research & Therapy

Key finding: In the cohort, 39.2% (67/171) tested positive by α-syn SAA. α-syn SAA positivity was more frequently detected alone than in combination with biomarkers of AD pathology (25.1% vs. 14.0%). α-syn SAA+ status was independently associated with higher odds of fluctuating cognition (OR 2.99, 95%CI 1.46–6.25, p = 0.012), visual hallucinations (OR 2.41, 95%CI 1.24–4.75, p = 0.027), extrapyramidal signs (OR 4.57, 95%CI 2.35–9.11, p < 0.001) and akinetic mutism (OR 3.77, 95%CI 1.22–12.82, p = 0.038). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

APOE ε4 and Cognition Among Middle-Aged and Older East Asian Adults

50/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: In their study, Chen et al 1 examined the association between apolipoprotein E (APOE) genotype and longitudinal cognitive trajectories among middle-aged and older East Asian adults participating in the Healthy Aging Longitudinal Study of Taiwan (HALST).Although sporadic late-onset Alzheimer disease

• Genetics
• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults

58/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: Among 4392 participants (mean [SD] age, 68.2 [7.8] years; 2359 [53.7%] women), 723 (16.5%) were APOE ε4 heterozygotes and 33 (0.8%) were APOE ε4 homozygotes. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

National trends in the prevalence of dementia in Medicare Advantage and Traditional Medicare

47/100 ✓ Peer-reviewed Health systems and care delivery BMC Health Services Research

Key finding: Among TM enrollees, prevalence of dementia was lower by 4% points in 2014 (9.0%, 95%CI: 7.8%, 9.3%) compared to 2000 (13.0%, 95%CI: 12%, 14%). +4 more findings

Full summary, score breakdown and related studies → Original source

Promoting Healthy Sleep–Wake and Circadian Rhythms to Prevent Delirium: Next Step, Target Engagement

60/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: First, based on pooled results of RCTs, the melatonin agonists melatonin and ramelteon were not found to reduce delirium incidence (RR 0.94, 95% CI 0.72–1.22, k = 16 studies; RR 0.63, 95% CI 0.39–1.03, k = 8, respectively). +4 more findings

• Prevention
• Lifestyle

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Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy

55/100 ✓ Peer-reviewed Inflammation and the immune system Science

Key finding: Together, these findings support the therapeutic potential of CAR-A as a disease-modifying strategy for AD.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Ethical Tensions in the Use of Real-Time Location Systems in Dementia Care: Balancing Safety, Privacy, and Autonomy

44/100 ✓ Peer-reviewed Caregiving The American Journal of Bioethics

Key finding: However, these technologies raise significant ethical concerns, particularly for vulnerable populations such as residents living with dementia.

• Side Effects

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The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model

49/100 ✓ Peer-reviewed Brain scans and imaging Molecular Psychiatry

Key finding: Collectively, these findings suggest that Aβ promotes gut symptoms through alteration of ENS connectivity and butyrate counteracts these impairments with an amelioration of neuroinflammation and memory function in AD model.

• Brain Biology

Full summary, score breakdown and related studies → Original source