Newest studies

What Helps or Hinders Annual Wellness Visits for Detection and Management of Cognitive Impairment Among Older Adults? A Scoping Review Guided by the Consolidated Framework for Implementation Research

33/100 ✓ Peer-reviewed Health systems and care delivery Nursing reports (Pavia, Italy)

Key finding: Among 19 included studies, most used quantitative designs and secondary data. +4 more findings

• Policy

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Smart Room Design for Dementia Nursing Home Based on Kano-AHP-QFD Integrated Methodology

33/100 ✓ Peer-reviewed Clinical safety HERD Health Environments Research & Design Journal

Key finding: BackgroundWith the growing demand for dementia-friendly care environments, existing smart room designs often lack systematic methods to translate user needs into functional solutions. +4 more findings

• Care Services

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MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model

51/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurodegeneration

Key finding: We identified several new mutations of MS4A6A with altered AD risks, and discovered specific correlation for some of them with the amount of β-amyloid in cerebrospinal fluid. +4 more findings

• Brain Biology

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Emerging Trends in Early Dementia Diagnosis: An Analysis on Advanced Machine Learning Approaches

32/100 ✓ Peer-reviewed Digital health tools ACM Computing Surveys

Key finding: Despite recent advances in dementia informatics research and AI, accurate early diagnoses are still far from ideal. +4 more findings

• Digital Tools
• Diagnosis

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Acceptability of wearable technology for the early detection of dementia-causing diseases: perspectives from the CODEC II cohort

41/100 ✓ Peer-reviewed Digital health tools BMC Digital Health

Key finding: Five key themes were identified, including ease of use, wearability, usefulness, transparency, and behavioral intention. +4 more findings

• Digital Tools
• Diagnosis

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Associations between traumatic brain injury and the prevalence of Alzheimer’s disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study

50/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: We assessed 452,718 patients (mean age: 67.16 years). +2 more findings

• Risk Factors

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Age-related hearing loss and dementia risk across the lifespan: mechanisms, equity, and prevention

41/100 ✓ Peer-reviewed Prevention and risk Neuroscience

Key finding: Age-related hearing loss (ARHL) has emerged as a significant and potentially modifiable risk factor for neurodegenerative disorders, including Alzheimer's disease.

• Risk Factors
• Prevention
• Health Equity

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GLP-1 receptor agonist semaglutide ameliorates motor deficits and tau pathology in the rTg4510s mouse model

43/100 ✓ Peer-reviewed Drug development Neuropharmacology

Key finding: Semaglutide significantly improved motor coordination in rTg4510 mice on the pole test, though not rotarod endurance. +4 more findings

• Treatments
• Brain Biology

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Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization

42/100 ✓ Peer-reviewed Vascular contributions Journal of Stroke and Cerebrovascular Diseases

Key finding: The relative risk of dementia following cerebral hemorrhage ( relative risk(RR):3.02[1.17-7.78],P<0.001 ) was higher than that of cerebral infarction (RR: 2.07[1.47-2.96], P<0.001). +4 more findings

• Risk Factors

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Rapidly Progressive Dementia After Platelet-Rich Plasma Therapy: A Case of Sporadic Creutzfeldt-Jakob Disease in the Context of Chronic Ehrlichiosis

33/100 ✓ Peer-reviewed End-of-life care Cureus

Key finding: MRI revealed multifocal cortical diffusion restriction involving the basal ganglia.

• Treatments

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C-reactive protein predicts functional decline in older adults newly diagnosed with dementia: A 5-year follow-up study

54/100 ✓ Peer-reviewed Cognitive tests and assessment Revista Española de Geriatría y Gerontología

Key finding: A total of 158 participants were included, with an average age of 75.2 years (SD 7.65). 60.8% (n=96) of patients had AD, and 39.2% (n=62) had LBD. +3 more findings

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Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia

37/100 ✓ Peer-reviewed Lewy body dementia Protein Science

Key finding: Biophysical and cellular assays demonstrated that both compounds more effectively inhibit the aggregation of mutant tau peptides compared to wild-type, with PUR preferentially targeting V287I and N279K variants, and OLC showing broader inhibitory activity. +3 more findings

• Other Dementias
• Treatments
• Brain Biology

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Supporting Individuals With Cognitive Impairment and Family Members in Rural Communities: Protocol for a Mixed Methods Digital Health Study

33/100 ✓ Peer-reviewed Digital health tools JMIR Research Protocols

Key finding: Data from the qualitative interviews will provide dyad preferences for intervention development. +3 more findings

• Digital Tools
• Caregiving
• Health Equity

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Integrative machine learning approach to risk prediction for dementia and Alzheimer’s disease

50/100 ✓ Peer-reviewed Digital health tools GeroScience

Key finding: These findings highlight the value of integrating diverse data sources for dementia risk prediction and emphasize the role of sex-specific modeling and modifiable factors in early, personalized intervention strategies.

• Digital Tools
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Neurodetector: EEG-Based Cognitive Assessment Using Event-Related Potentials as a Virtual Switch

35/100 ✓ Peer-reviewed Getting a diagnosis Brain Sciences

Key finding: The participants controlled the EEG Switch above chance level across all tasks. +4 more findings

• Diagnosis

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Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia

55/100 ✓ Peer-reviewed Getting a diagnosis Molecular Neurodegeneration

Key finding: Forty-three proteins were differentially regulated in FTD compared to controls and AD, reflecting axon development, regulation of synapse assembly, and cell-cell adhesion mediator activity pathways. +4 more findings

• Biomarkers
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Stepwise approach to alzheimer's disease diagnosis in primary care using cognitive screening, risk factors, neuroimaging and plasma biomarkers

52/100 ✓ Peer-reviewed Tau biomarkers Scientific reports

Key finding: We evaluated the diagnostic performance of a scalable, multimodal framework in a real-world, population-based cohort. +3 more findings

• Diagnosis
• Biomarkers
• Care Services

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Plasma and neurostructural biomarkers in the clinical-biological characterization of early stages of the Alzheimer's disease continuum: findings from the Compostela Aging Study

45/100 ✓ Peer-reviewed Tau biomarkers The journal of prevention of Alzheimer's disease

Key finding: The main objective of this study was to contribute to the clinical-biological characterization of the initial stages of cognitive impairment by measurement of blood and neurostructural AD biomarkers in groups of participants classified according to their cognitive clinical phenotype. +3 more findings

• Biomarkers

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Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial

62/100 ✓ Peer-reviewed Treatments The American journal of clinical nutrition

Key finding: Higher plasma carotenoid concentrations were associated with slower cognitive decline in APOE ε4 carriers, potentially mitigating genetic risk. +2 more findings

• Clinical Trials
• Genetics
• Lifestyle

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PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice

43/100 ✓ Peer-reviewed Risk factors Ecotoxicology and environmental safety

Key finding: Ambient fine particulate matter (PM2.5) is a key environmental risk factor closely associated with Alzheimer's disease (AD), although its specific molecular mechanisms remain incompletely elucidated. +3 more findings

• Brain Biology
• Digital Tools

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Progress of radiomics research on white matter hyperintensity lesions

33/100 ✓ Peer-reviewed Vascular contributions Frontiers in Neurology

Key finding: This phenomenon is closely related to nervous system damage, such as cognitive impairment, dementia and increased risk of stroke. +1 more finding

• Brain Scans

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Survival Variations Based on Hospice Qualifying Condition: A Retrospective Review

33/100 ✓ Peer-reviewed End-of-life care American Journal of Hospice and Palliative Medicine®

Key finding: The median survival duration overall was 17.36 days (Inter-quartile range 5.35-62.08). +1 more finding

• End-of-Life Care

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Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study

48/100 ✓ Peer-reviewed Prevention trials Frontiers in Aging Neuroscience

Key finding: Out of 180 subjects, 74 showed short-term training gain transfer that was maintained over 3 months in 19 subjects. +4 more findings

• Clinical Trials

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Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and Neuroinflammation

40/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Furthermore, type 2 diabetes (T2DM) and metabolic syndrome (MS) have also been observed to be early markers that may provoke pathogenic pathways that lead to or aggravate AD progression and pathology. +4 more findings

• Brain Biology
• Genetics

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ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice

47/100 ✓ Peer-reviewed Inflammation and the immune system Nature Communications

Key finding: Our results reveal that part of TBK1-linked FTD disease originates from microglial dysfunction.

• Brain Biology

Full summary, score breakdown and related studies → Original source