Newest studies

Modifiable factors associated with cognitive health trajectories among Indigenous, Hispanic, Black, and White older adults: an exploratory longitudinal panel analysis of the health and retirement study with a focus on Indigenous peoples

54/100 ✓ Peer-reviewed Disparities The Lancet Regional Health - Americas

Key finding: This diverse sample of Indigenous (1.65%), Black (11.43%), Hispanic (9.85%), and White (77.07%) older adults had a mean age of 61 (SD = 9.66) and was 52% female. +3 more findings

• Health Equity
• Prevention

Full summary, score breakdown and related studies → Original source

Storytelling in family-provided care - developing diversity-sensitive stories for family caregivers of Turkish individuals living with dementia

37/100 ✓ Peer-reviewed Caregiving BMC Nursing

Key finding: The study resulted in the creation of nine storytelling packs, each containing five stories tailored to specific caregiver personas. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study

47/100 ✓ Peer-reviewed Risk factors Alzheimer s Research & Therapy

Key finding: In the LA cohort only, higher WMHs load was associated with greater GM atrophy across all groups (HCs, AD, bvFTD), with a specific neurodegenerative pattern involving orbitofrontal, cingulate, and temporal areas. +4 more findings

Full summary, score breakdown and related studies → Original source

Single-cell transcriptome analysis reveals dysregulation of microglial iron homeostasis in temporal lobe epilepsy

43/100 ✓ Peer-reviewed Genetics Brain research

Key finding: Abnormal accumulation of iron and lipid peroxides in the brain of TLE patients has been demonstrated. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Downstream Revenue Generated After Visits to Neurologists: A Claims-Based Analysis of Medicare Data

40/100 ✓ Peer-reviewed Health systems and care delivery Neurology. Clinical practice

Key finding: To determine downstream revenue of neurologists compared with nonneurologists after incident diagnostic visits by analysis of Medicare claims. +3 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Emergency Department Care Coordination Program for Assisted Living Residents With Dementia

37/100 ✓ Peer-reviewed End-of-life care JAMA Network Open

Key finding: Of 22 total CCMs, 12 participated in this study (employed as a CCM for a median [IQR] of 2 [1-3] years; 12 [100%] female) and identified populations that they perceived to especially benefit from the program, including PLWD, patients in hospice, and patients living in group homes. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Patient- and Caregiver-Identified Goals for Advance Care Planning in Patients With Dementia or Cognitive Impairment

35/100 ✓ Peer-reviewed End-of-life care Dementia

Key finding: Most participants in the sample had not participated in a prior ACP conversation with a primary care provider. +4 more findings

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Incidence and perioperative risk factors for postoperative delirium in the intensive care unit among adult surgical patients – Retrospective cohort study

42/100 ✓ Peer-reviewed Clinical safety Indian Journal of Anaesthesia

Key finding: Affected patients were older, in poorer preoperative health, and had longer anaesthesia and surgery times. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Exploring Lymphovenous Anastomosis for Alzheimer Disease: Addressing Brain Lymphatic Dysfunction, Feasibility, and Outcome Metrics

38/100 ✓ Peer-reviewed Inflammation and the immune system Plastic & Reconstructive Surgery

Key finding: Alzheimer disease is a multifactorial neurodegenerative disorder characterized by amyloid-beta plaques, tau tangles, and neuroinflammation, with emerging evidence highlighting a potential role for brain lymphatic dysfunction. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior play a key role

39/100 ✓ Peer-reviewed Brain tissue and pathology Environmental Research

Key finding: UFPM/NPs produce oxidative stress and striking tissue retention and magnetic effects. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Reducing Neuroinflammation and Risk of Mild Cognitive Impairment and Alzheimer’s Disease by Reducing Dietary Lipopolysaccharides, Arachidonic Acid, and Advanced Glycation End Products

28/100 ✓ Peer-reviewed Mild cognitive impairment Journal of dementia and Alzheimer's disease

Key finding: Triggered by LPS and AGEs in food, inflammatory cytokines can enter the brain and stimulate microglial activation, inflammation, and oxidative damage. +4 more findings

• Brain Biology
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Sex Differences in Mortality and Health Care Utilization After Dementia Diagnosis

62/100 ✓ Peer-reviewed Caregiving JAMA Neurology

Key finding: A total of 5 721 711 patients (3 302 579 female and 2 419 132 male) with incident dementia between 2014 and 2021 were included in the study. +4 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cardiovascular-kidney-metabolic health, genetic susceptibility, and the risk of dementia: A prospective cohort study

53/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: Among 331,731 participants (mean ± SD age, 56.53 ± 8.1 years; 156,762 [47.26 %] male), 4413 (1.33 %) developed dementia during a mean follow-up of 12.8 years. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Protective Effects of Socioeconomic Status and Lifestyle on Amyloid‐ and White Matter Hyperintensity ‐Related Longitudinal Brain Atrophy and Cognitive Decline

54/100 ✓ Peer-reviewed Vascular contributions Annals of Neurology

Key finding: SES and LA were associated with better cognitive performance at baseline, but were not associated with cognitive decline over time. +4 more findings

• Brain Scans
• Prevention

Full summary, score breakdown and related studies → Original source

Association of Cognition, Frailty, & Peak Airflow With Dysphagia in Older Adults: A National Study

42/100 ✓ Peer-reviewed Clinical safety The Laryngoscope

Key finding: This study included 5899 older adults (65+) of whom 687 reported dysphagia (median age, 80 years; 62.2% female). +4 more findings

Full summary, score breakdown and related studies → Original source

Divergent and convergent TMEM106B pathology in murine models of neurodegeneration and human disease

40/100 ✓ Peer-reviewed Disease mechanisms Acta Neuropathologica Communications

Key finding: We found profound correlations between the endogenous TMEM106B protein with known TDP-43 and tau pathology in murine models of C9-ALS/FTD and tauopathy, respectively.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Changes in sleep dimensions, cognitive transitions, and incident dementia: a two-cohort longitudinal study

55/100 ✓ Peer-reviewed Risk factors SLEEP

Key finding: A total of 8994 and 14 720 participants were involved in the change-to-change analyses and change-to-dementia analyses, respectively. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Alzheimer's disease: Clinical trials to watch

43/100 ✓ Peer-reviewed Drug development Med (New York, N.Y.)

Key finding: Second-generation anti-amyloid therapies (ATTs) offer new options for early Alzheimer's disease treatment, but with modest efficacy and documented adverse events. +1 more finding

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Biological Age and Age Acceleration Predict Alzheimer's Disease Plasma Biomarker Levels

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv : the preprint server for health sciences

Key finding: Epigenetic clocks can predict pathological aging associated with Alzheimer's disease (AD) risk, albeit findings are mixed regarding if clocks are predictive in blood and in non-European populations. +3 more findings

• Biomarkers

Scored 25 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Cerebral small vessel disease and multiple sclerosis: Similarities and differences

29/100 ✓ Peer-reviewed Vascular contributions Meditsinskiy sovet = Medical Council

Key finding: But modern science finds significant similarities between “purely vascular” and immune-mediated diseases.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cognitive feature evaluation for disease progression in dementia and its precursors using feature selection

33/100 ✓ Peer-reviewed Cognitive tests and assessment Health and Technology

Key finding: The results of this study identified important relationships between cognitive features in the ADAS-Cog and provide a clear example of the value of data-driven machine learning approaches in the identification of markers that indicate disease progression in dementia. +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

The National Dementia Workforce Study: Methods for Surveying Community Clinicians Who Provide Care to People With Dementia

44/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: The National Dementia Workforce Study (NDWS), sponsored by the National Institute on Aging, is conducting large nationally representative surveys of health care workers who provide care to people with dementia in nursing homes, assisted living communities, home care, and community medical practices. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Comorbid Pathologies and Their Impact on Dementia with Lewy Bodies—Current View

42/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Molecular Sciences

Key finding: Neuropathological studies have demonstrated a high prevalence of coexistent AD-related neuropathological changes (ADNC), TAR DNA-binding protein 43 (TDP-43) proteinopathies, and cardiac and aging-related disorders, while frontotemporal lobar degeneration (FTLD) and tau-related syndromes play a minor role as DLB-related co-pathologies.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry

47/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: ε4, socioeconomic status, physical activity, smoking, subjective cognitive decline, and various cardiovascular risk factors and comorbidities. +3 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: In CU individuals from the development cohort, the combination of p-tau217 and Aβ42/40 significantly improved diagnostic accuracy (AUC: ALZpath 0.937 vs. 0.905, MSD 0.901 vs. 0.861; p < 0.05, DeLong test; 95% CIs) and model fit (AIC /BIC, p < 0.001) compared to p-tau217 alone. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source