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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

Out of 180 subjects, 74 showed short-term training gain transfer that was maintained over 3 months in 19 subjects. Neither microstructural integrity of the corpus callosum, nor bilateralized activation predicted training gain transfer alone. However, their interaction was associated with long-term transfer over 3 months: subjects with higher mean diffusivity of the corpus callosum and more bilateral functional activity or conversely with lower diffusivity of the corpus callosum and more lateral functional activity were more likely successful long-term transferers. We demonstrated successful training gain transfer in 41.1% of subjects, among whom 25.7% maintained the transfer over 3 months. Successful long-term transfer of training gains may depend on divergent mechanisms of structural and functional connectivity, which may explain previous heterogeneous results in the literature. Trial register: German Clinical Trials Register (DRKS), ID: DRKS00013077. Registered on November 19th 2017.

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APA 7th

Fischer, F. U., Kollmann, B., Wolf, D. G. F., Sebastian, A., Knaepen, K., Riedel, D., et al. (2025). Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2025.1587395

Vancouver

Fischer FU, Kollmann B, Wolf DGF, Sebastian A, Knaepen K, Riedel D, et al. Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study. Frontiers in Aging Neuroscience. 2025. doi:10.3389/fnagi.2025.1587395. PMID: 40933821.

BibTeX

@article{fischer2025-40933821,
  author  = {Fischer, Florian U. and Kollmann, Bianca and Wolf, Dominik Georg Friedrich and Sebastian, Alexandra and Knaepen, Kristel and Riedel, David and Mierau, Andreas and Ruffini, Nicolas and others},
  title   = {{Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1587395},
  pmid    = {40933821},
  url     = {https://doi.org/10.3389/fnagi.2025.1587395}
}

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Key findings

Out of 180 subjects, 74 showed short-term training gain transfer that was maintained over 3 months in 19 subjects.
Neither microstructural integrity of the corpus callosum, nor bilateralized activation predicted training gain transfer alone.
However, their interaction was associated with long-term transfer over 3 months: subjects with higher mean diffusivity of the corpus callosum and more bilateral functional activity or conversely with lower diffusivity of the corpus callosum and more lateral functional activity were more likely successful long-term transferers.
We demonstrated successful training gain transfer in 41.1% of subjects, among whom 25.7% maintained the transfer over 3 months.
Successful long-term transfer of training gains may depend on divergent mechanisms of structural and functional connectivity, which may explain previous heterogeneous results in the literature.

Why it matters

In this cognitive training study of 180 cognitively healthy older adults, 74 showed short-term transfer of training gains and 19 maintained it over 3 months. Long-term transfer appeared to depend on a combination of brain structure and function, which may explain mixed results in earlier studies.

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Study details

Participants235
Effect size41.1%; 25.7%
Evidence strengthLow

How this study scored 48/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in Aging Neuroscience)
Journal's citation record	2 / 4	Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	235 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Oliver Tüscher: h-index 59 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Freiburg: institution h-index 1,068 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 18 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40933821)
Free to read	2 / 2	Free to read
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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