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Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization
Meng Jin, Jingjing Liu, Ziyi Bao, Xiaqing Hong, Songbin He, Feng Gao. Journal of Stroke and Cerebrovascular Diseases, 2025-08-27
Topic: Risk, prevention and care in population studies
The relative risk of dementia following cerebral hemorrhage ( relative risk(RR):3.02[1.17-7.78],P<0.001 ) was higher than that of cerebral infarction (RR: 2.07[1.47-2.96], P<0.001). However, due to the high prevalence of cerebral infarction, the PAF for dementia due to cerebral infarction was higher than that of cerebral hemorrhage. Together, they explain 1.31% (1.41%-1.21%) of global dementia. The burden of dementia following both cerebral infarction and cerebral hemorrhage showed significant spatial and temporal heterogeneity. Four causal associations were replicated in two-sample MR and a mediating role for cerebrospinal fluid(CSF) metabolites X-11261 was identified by 2-step MR. one point three one percent of dementia prevalence globally could be explained by ischemic stroke and hemorrhagic stroke.Quantifying the proportion of dementia caused by these two conditions has helped us to gain a comprehensive understanding of the causes of dementia.Through two-sample MR study and two-step MR analysis, modifiable risk factors and cerebrospinal fluid mediators associated with vascular dementia were identified, elucidating intervention methods for preventing or delaying the typical characteristics of dementia. This is crucial for future efforts in disease prevention and treatment.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jin, M., Liu, J., Bao, Z., Hong, X., He, S., & Gao, F. (2025). Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization. Journal of Stroke and Cerebrovascular Diseases. https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108443
Vancouver
Jin M, Liu J, Bao Z, Hong X, He S, Gao F. Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization. Journal of Stroke and Cerebrovascular Diseases. 2025. doi:10.1016/j.jstrokecerebrovasdis.2025.108443. PMID: 40882898.
BibTeX
@article{jin2025-40882898,
author = {Jin, Meng and Liu, Jingjing and Bao, Ziyi and Hong, Xiaqing and He, Songbin and Gao, Feng},
title = {{Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization}},
journal = {Journal of Stroke and Cerebrovascular Diseases},
year = {2025},
doi = {10.1016/j.jstrokecerebrovasdis.2025.108443},
pmid = {40882898},
url = {https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108443}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The relative risk of dementia following cerebral hemorrhage ( relative risk(RR):3.02[1.17-7.78],P<0.001 ) was higher than that of cerebral infarction (RR: 2.07[1.47-2.96], P<0.001).
- However, due to the high prevalence of cerebral infarction, the PAF for dementia due to cerebral infarction was higher than that of cerebral hemorrhage.
- Together, they explain 1.31% (1.41%-1.21%) of global dementia.
- The burden of dementia following both cerebral infarction and cerebral hemorrhage showed significant spatial and temporal heterogeneity.
- Four causal associations were replicated in two-sample MR and a mediating role for cerebrospinal fluid(CSF) metabolites X-11261 was identified by 2-step MR. one point three one percent of dementia prevalence globally could be explained by ischemic stroke and hemorrhagic stroke.Quantifying the propor
Why it matters
This study found that dementia risk was higher after cerebral hemorrhage than after cerebral infarction, but because infarction is more common it accounted for a larger share of dementia, with the two together explaining 1.31% of global dementia. It also identified a cerebrospinal fluid metabolite as a possible mediator, suggesting intervention targets for future prevention work.
Study details
- Effect sizeRR: 2.07; 1.31%; 1.41%
- Evidence strengthHigh
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 40 of the 96 points we could judge it on, which is 42 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Stroke and Cerebrovascular Diseases) |
| Journal's citation record | 1 / 4 | Journal of Stroke and Cerebrovascular Diseases: journal h-index 104 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Feng Gao holds only 6 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40882898) |
| Free to read | 2 / 2 | Free to read |
| Points | 40 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 40 of the 96 points we could judge it on is 42 out of 100. |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.jstrokecerebrovasdis.2025.108443
- PubMed: 40882898
- Original source →
- Free full text: Journal of Stroke and Cerebrovascular Diseases →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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