Newest studies

Evaluation of oxidative stress biomarkers in mild cognitive impairment and Alzheimer’s disease: targeting dynamic thiol–disulfide homeostasis and ischemia-modified albumin

35/100 ✓ Peer-reviewed Mild cognitive impairment Neurological Research

Key finding: Hypertensive patients also had significantly lower thiol levels compared to those without hypertension (p < 0.05).Conclusion Our findings suggest that total and native thiol levels decline with cognitive deterioration and advancing age. +3 more findings

• Early Stage
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Disagreement between self- and informant-reported memory complaints and progression of mild cognitive impairment to dementia

41/100 ✓ Peer-reviewed Mild cognitive impairment Aging & Mental Health

Key finding: Underreporters showed lower cognitive performance (p = 0.021), which did not translate into higher self-report SMC (p = 0.092). +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation

46/100 ✓ Peer-reviewed Lewy body dementia npj Parkinson s Disease

Key finding: These findings reveal distinct roles of C-terminal truncations at different aggregation stages on the pathway to LB formation, highlighting the need for consideration of stage‑specific strategies to target aSyn proteolytic cleavages.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Deprescribing for People with Dementia: A Roadmap

41/100 ✓ Peer-reviewed Caregiving Drugs & Aging

Key finding: Appropriate deprescribing of unnecessary or potentially inappropriate medications is essential to high-quality care for PWD, to avoid iatrogenic harm and improve health and well-being for patients and their care partners. +4 more findings

• Side Effects

Full summary, score breakdown and related studies → Original source

Inflammatory changes in early dementia with Lewy bodies

47/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Neurology

Key finding: Our data show changes in innate immune cells in MCI-LB compared to healthy controls in this small exploratory study. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial

76/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: 2,111 participants aged 60-79 randomized to structured (n=1,056) vs self-guided (n=1,055) 2-year lifestyle interventions +3 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Causal effect of conventional anti-dementia drugs on economic burden: an orthogonal double/debiased machine learning approach

46/100 ✓ Peer-reviewed Costs and economics BMC geriatrics

Key finding: A total of 12,764,487 weighted older adults with ADRD were included, with 34.60% of them using anti-dementia drugs. +4 more findings

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Donanemab for Alzheimer's disease: from preclinical research to the clinical application

71/100 ✓ Peer-reviewed Treatments Expert review of neurotherapeutics

Key finding: Donanemab (Kisunla) is a humanized IgG1 monoclonal antibody specifically targeting a modified form of β-amyloid found predominantly within plaques (characterized as N-terminal pyroglutamate Aβ).

• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Cognitive Decline and Dementia in Chronic Widespread Pain: A Longitudinal Population-based Study

56/100 ✓ Peer-reviewed Long-term cohort studies Anesthesiology

Key finding: This study analyzed 13 yr of follow-up data from 188,594 participants to assess the relationship between CWP and cognitive outcomes, while exploring the mediating effects of brain structure and systemic inflammation. +4 more findings

Full summary, score breakdown and related studies → Original source

Mild Cognitive Impairment: A Pre-Dementia Syndrome

29/100 ✓ Peer-reviewed Mild cognitive impairment Batna Journal of Medical Sciences (BJMS)

Key finding: Mild Cognitive Impairment (MCI) is a neuropsychological clinical condition regarded as a prodromal stage of dementia, characterized by cognitive decline without significant impairment in daily functioning or autonomy.

• Early Stage

Full summary, score breakdown and related studies → Original source

Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes

61/100 ✓ Peer-reviewed Prevention and risk Annals of Internal Medicine

Key finding: The 6-year absolute risk was 12.0% (95% CI, 11.9% to 12.1%) in the control group (349 cases) and 9.5% (CI, 9.4% to 9.5%) in the intervention group (280 cases). +4 more findings

• Lifestyle
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function

57/100 ✓ Peer-reviewed Prevention and risk Nature Medicine

Key finding: Here we show that the associations of 57 metabolites with dementia risk varied by APOE4 genotype or other AD/ADRD risk variants. +2 more findings

• Lifestyle
• Genetics
• Prevention

Full summary, score breakdown and related studies → Original source

A novel C. elegans model for MAPT/Tau spreading reveals genes critical for endolysosomal integrity and seeded MAPT/Tau aggregation

42/100 ✓ Peer-reviewed Genetics Autophagy

Key finding: The spreading of MAPT/Tau pathology is closely associated with the progression of neurodegeneration and cognitive decline in Alzheimer disease and other tauopathies. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

The impact of polygenic risk for alzheimer’s disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum

36/100 ✓ Peer-reviewed Genetics Neurological Sciences

Key finding: In the whole sample, both PRSs were associated with the strength of correlation between GMV and different serotonin receptors and fluorodopa uptake. +1 more finding

• Genetics
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation

42/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s Research & Therapy

Key finding: We observed a nonlinear trajectory of two functional connectivity metrics-temporal variability (fluidity) and connectedness (average node strength)-across symptom severity, especially in the delta frequency band. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Behavioral variant frontotemporal dementia as a model for understanding the cognitive and cerebral determinants of verbal creativity

40/100 ✓ Peer-reviewed Lewy body dementia Behavioral and Brain Functions

Key finding: We dissociated four key cognitive components underlying remote thinking: spontaneous associative thinking, inhibition of unoriginal responses, intentional remote associative thinking, and verbal initiation; and replicated them in three independent datasets. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment

43/100 ✓ Peer-reviewed Inflammation and the immune system Translational neurodegeneration

Key finding: We identified a significant upregulation of COX-1 in 5 × FAD mice, with expression specifically localized to microglia in an age-dependent manner. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma tau biomarkers for biological staging of Alzheimer's disease

71/100 ✓ Peer-reviewed Biomarkers Nature aging

Key finding: Our results revealed that specific tau species became abnormal at different points along the disease continuum. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Among 6437 participants screened, with non-Hispanic (NH) White as the reference group, odds ratios of plasma ineligibility were 2.88 (95% confidence interval [CI]: 1.40-6.96) for Hispanic Black, 1.60 (95% CI: 1.33-1.92) for Hispanic White, 2.10 (95% CI: 1.37-3.38) for NH Asian, and 1.59 (95% CI: 1.27-2.0) for NH Black participants. +2 more findings

• Biomarkers
• Health Equity
• Brain Scans

Full summary, score breakdown and related studies → Original source

Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia

40/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95% CI 0.537-0.865). +3 more findings

Full summary, score breakdown and related studies → Original source

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease

39/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: These findings highlight hippocampal atrophy as a key pathway linking Aβ burden to cognitive impairment. +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

The association between plasma and MRI biomarkers in dementia with lewy bodies

44/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s Research & Therapy

Key finding: In DLB, plasma concentrations of GFAP and NfL were associated with MTA, GCA-F, and Fazekas scale; and the Aβ42/40 ratio was associated with PA and Fazekas. +4 more findings

• Other Dementias
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Biomarcadores de laboratorio en la enfermedad de Alzheimer: avances recientes e implantación en un hospital de tercer nivel

26/100 ✓ Peer-reviewed Treatments Kranion

Key finding: ResumenLa enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa crónica que se caracteriza por la acumulación excesiva de proteína beta-amiloide y de proteína Tau fosforilada.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Treating Alzheimer Disease With Antiamyloid Therapies—The Real-World Experience Grows

41/100 ✓ Peer-reviewed Treatments JAMA

Key finding: This Medical News article discusses the safety and effectiveness of lecanemab and donanemab in treating mild cognitive impairment and early Alzheimer disease outside clinical trials.

• Treatments

Full summary, score breakdown and related studies → Original source

Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults

50/100 ✓ Peer-reviewed Genetics Neurology

Key finding: This study suggests 2 molecular pathways underlying CAA, with a larger effect size for the pathway including SFRP1 and APOE protein and C-terminally truncated Aβ before position 40. +1 more finding

Full summary, score breakdown and related studies → Original source