Newest studies

National trends in cerebrospinal fluid biomarker testing for Alzheimer's disease in Japan

43/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease reports

Key finding: The annual number of health insurance claims for p-tau181 testing gradually increased from 1358 (2014) to 3420 (2023); 79-86% of claims were from inpatient settings throughout the study period. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cerebral small vessel disease unveils a vascular pathway to motoric cognitive risk in aging

55/100 ✓ Peer-reviewed Vascular contributions Journal of Alzheimer s Disease

Key finding: In this multi-cohort study of older adults without cognitive impairment, we show that WMH and lacunes independently predict increased risk of MCR, after adjusting for key confounders. +4 more findings

• Other Dementias
• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

Expanding the Boundaries of Palliative Care: Diseases of the Nervous System and Survival Prognosis in Home-Based Programs

44/100 ✓ Peer-reviewed End-of-life care American Journal of Hospice and Palliative Medicine®

Key finding: DNS conditions, particularly dementia, were associated with longer survival among non-oncologic HBPC patients. +3 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The role of the MIND diet in Alzheimer's disease patients: A case-control study on malnutrition and depression

37/100 ✓ Peer-reviewed Prevention trials Nutrition

Key finding: These findings suggest that adherence to the MIND diet may support nutrition and psychological well-being in AD and highlight the value of integrating nutrition-based approaches into dementia care. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Disparity of Prescribed Psychotropics in Alzheimer’s Disease with Neuropsychiatric Symptoms

42/100 ✓ Peer-reviewed Disparities Pharmacoepidemiology

Key finding: A total of 7031 AD patients were identified. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Usability of a Tablet-Based Cognitive Assessment Administered by Medical Assistants in General Practice: Implementation Study

34/100 ✓ Peer-reviewed Getting a diagnosis JMIR Formative Research

Key finding: The results indicated good usability for the MoCA Duo. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Should we include dementia diagnosis or cognitive impairment to predict home care cost? An observational study using real-world data

38/100 ✓ Peer-reviewed Health systems and care delivery BMC Health Services Research

Key finding: Among the 1,035 patients in our dataset, 176 (17%) had a dementia diagnosis. +4 more findings

• Care Services
• Policy
• Diagnosis

Full summary, score breakdown and related studies → Original source

Should we include dementia diagnosis or cognitive impairment to predict home care cost? : an observational study using real-world data

33/100 ✓ Peer-reviewed Health systems and care delivery Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences)

Key finding: Among the 1,035 patients in our dataset, 176 (17%) had a dementia diagnosis. +4 more findings

• Care Services
• Policy
• Diagnosis

Full summary, score breakdown and related studies → Original source

Utility of the Amygdalar Atrophy Scale to Identify Patients With Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Memory Clinic

56/100 ✓ Peer-reviewed Laboratory science Neurology

Key finding: The analytic sample included 469 participants (mean age 71.2 ± 8.5 years, 53% female). +2 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Menopause hormone therapy and risk of mild cognitive impairment or dementia: a systematic review and meta-analysis

66/100 ✓ Peer-reviewed Prevention and risk The Lancet Healthy Longevity

Key finding: No significant association was found between MHT use and risk of mild cognitive impairment or dementia. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer's Disease Rat Model

45/100 ✓ Peer-reviewed Prevention trials Neurochemical research

Key finding: Aβ injection significantly impaired learning and memory and reduced hippocampal levels of PKA, CREB, and BDNF (p < 0.001). +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Mapping research trends and competency domains in nursing-related digital and artificial intelligence technologies: A bibliometric analysis

38/100 ✓ Peer-reviewed Digital health tools International Journal of Nursing Sciences

Key finding: A total of 83,807 articles were included for bibliometric analysis. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Montreal Cognitive Assessment (MoCA) Scale: Strengths, Limitations, and Implication for Clinical Practice

32/100 ✓ Peer-reviewed Getting a diagnosis Iranian Journal of Psychiatry

Key finding: The MoCA shows superior sensitivity for MCI detection compared to the Mini-Mental State Examination (MMSE), with strengths in brevity, multidomain coverage, and accessibility. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Comparative dementia risk with GLP1 receptor agonists, SGLT2 inhibitors, or DPP4 inhibitors: a population-based cohort study

58/100 ✓ Peer-reviewed Prevention and risk Alzheimer's Research & Therapy

Key finding: In the intention-to-treat analysis, dementia risk was not different between GLP1-RA and DPP4i initiators (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.87–1.04; rates: 6.29 versus 6.64 per 1000 person-years; mean follow-up: 6.54 years); however, continuous GLP1-RA versus DPP4i use was associated with a 21% lower risk (HR 0.79, 95% CI 0.64–0.97; rates: 3.64 versus 4.82; mean follow-up: 2.71 years). +3 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches

43/100 ✓ Peer-reviewed Drug development Antibodies (Basel, Switzerland)

Key finding: They offer distinct engineering benefits compared with traditional antibodies and small molecules, including small size, stability, and specificity. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Immediate reactions to amyloid PET disclosure in Japanese older adults without dementia

54/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (New York, N. Y.)

Key finding: Twenty-six percent of participants were PET positive. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Trem2R47H and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv : the preprint server for biology

Key finding: Trem2*R47H mice had alternative splicing leading to reduced Trem2 expression; Trem2*R47HHSS mice expressed Trem2 at wild-type transcript and protein levels. +3 more findings

• Genetics
• Brain Biology

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation

35/100 ✓ Peer-reviewed Risk genes beyond APOE Structure

Key finding: Moreover, we found that bulky aromatic mutations within the 16 amino acid extension of C99 interfere with exosite binding and inhibit substrate cleavage. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Delirium prevalence and incidence in acutely admitted older patients: an observational cohort study

48/100 ✓ Peer-reviewed How common it is BMC Geriatrics

Key finding: length of stay, need for a higher level of care, and mortality after discharge in patients with and without delirium. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Global, Regional, and National Disparities in the Burden of Alzheimer’s Disease and Other Dementias, 1990–2021

41/100 ✓ Peer-reviewed Disparities Neuroepidemiology

Key finding: In 2021, the age-standardised rates for ADOD were 694.01 (95% uncertainty intervals [UIs]: 602.88 to 794.08) for prevalence, 119.76 (95% UI: 104.96 to 135.89) for incidence, and 481.70 (95% UI: 228.79 to 1,023.96) for disability-adjusted life years (DALYs). +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Biología en la sangre: avances en biomarcadores plasmáticos para el diagnóstico de la enfermedad de Alzheimer

27/100 ✓ Peer-reviewed Genetics Star of Sciences Multidisciplinary Journal

Key finding: El cociente Aβ42/40 refleja con alta sensibilidad la carga amiloide cerebral, mientras que las isoformas p-tau181 y p-tau217 indican la propagación de la patología tau. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Remote assessments of sleep and cognition in cognitively normal older adults at risk for Alzheimer disease

39/100 ✓ Peer-reviewed Genetics Sleep Medicine

Key finding: At the between-person level, no associations were observed between sleep and cognition. +4 more findings

• Genetics
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

A APOLIPOPROTEINA E (APOE) E SUAS ISOFORMAS NA DOENÇA DE ALZHEIMER

27/100 ✓ Peer-reviewed Genetics Revista Contemporânea

Key finding: A análise crítica dos estudos permitiu avaliar a relação entre a APOE, suas variantes e processos como deposição de β-amiloide, neuroinflamação, reparo sináptico e metabolismo lipídico. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia

41/100 ✓ Peer-reviewed Risk factors Schizophrenia Research

Key finding: The effect of ADI score was also significant, β = -0.36, t = -2.30, p < .05; while the effect of RUCC, β = 0.06, t = 0.34, p = .73, and the interaction between ADI and RUCC, β = -0.001, t = 0.27, p = .99, were nonsignificant. +2 more findings

Full summary, score breakdown and related studies → Original source

Genetic architecture of Alzheimer’s disease-related plasma biomarkers

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: The observed phenotypic and genetic associations highlight shared underlying mechanisms among plasma biomarkers. +1 more finding

• Biomarkers
• Genetics

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source