Newest studies

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau

40/100 ✓ Peer-reviewed Disease mechanisms Science Advances

Key finding: The accumulation of pathological four-repeat (4R) tau is central to several frontotemporal dementia (FTD) subtypes, but human neuronal models amenable to high-throughput screening of 4R tau-targeting therapies remain very limited.

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Electroretinography as a Noninvasive Biomarker of Alzheimer’s Disease and Related Dementias in Older Adults: A Systematic Scoping Review

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

Key finding: Irrespective of ERG modality, ADRD was consistently associated with retinal dysfunction marked by impaired synaptic transmission and delayed neural processing across retinal circuits. +2 more findings

• Biomarkers

Scored 53 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Serum brain-derived p-tau 217 and SV2A Reduce Peripheral Interference in Alzheimer’s Disease: A Multicohort Study

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv

Key finding: Our findings suggest that serum brain-derived p-tau 217 and SV2A are more specific diagnostic biomarkers for reflecting brain damage and may not be disturbed by peripheral damage for AD patients. +4 more findings

• Biomarkers

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Gut-Brain Axis Mechanism in Alzheimer’s Disease: From Animal Models to Clinical Translation and Innovative Treatment Strategies

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Preprints.org

Key finding: Human studies consistently demonstrate that alterations in gut microbiota span the entire spectrum of AD, from the preclinical stage to dementia, and are associated with Amyloid-beta (Aβ) deposition, phosphorylated Tau (p-tau) positivity, dysregulation of bile acid and short-chain fatty acid (SCFA) metabolism, as well as impaired intestinal barrier function. +2 more findings

• Brain Biology
• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Artificial Intelligence in Alzheimer’s Disease: Evidence Maturity and Clinical Translation Across the Care Pathway

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Preprints.org

Key finding: This scoping-informed methodological review maps AD-AI evidence across prevention and risk stratification, diagnosis and staging, treatment and therapeutic monitoring, and care and safety support, drawing on PubMed/MEDLINE, IEEE Xplore, ACM Digital Library, ScienceDirect/Scopus-indexed venues, Google Scholar, and citation chaining for literature from 2000 to May 2026. +4 more findings

• Treatments
• Digital Tools

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Altered T1w/T2w-FLAIR Ratio in White Matter Hyperintensities as an Indicator of Structural Integrity Loss: Association with Alzheimer’s Disease and Vascular Dementia

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: Residualized WMH T1w/T2w-FLAIR ratio captures lesion-specific microstructural variation missed by volumetric measures, consistent with vascular-gliotic injury in VD and coexisting amyloid-linked demyelination in AD. +3 more findings

• Brain Scans
• Early Stage
• Other Dementias

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Biomarker-Informed Interpretation of Dyadic Cognitive Function Index Scores in Cognitively Unimpaired Older Adults

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: Amyloid regional extent and tau PET were associated with different features of dyadic CFI data: reporter balance and CFI burden across reporters, respectively. +3 more findings

• Biomarkers

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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BACH1/HO-1 axis dysregulation links Down syndrome to Alzheimer-like neurodegeneration

31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurochemistry international

Key finding: Down syndrome (DS), caused by trisomy of chromosome 21, is characterized by early-onset oxidative stress, impaired neuronal development, and an increased risk of Alzheimer's disease (AD)-like neuropathology. +1 more finding

• Down Syndrome
• Brain Biology

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Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline: Biological Rationale and Current Evidence

48/100 ✓ Peer-reviewed Clinical safety Nutrients

Key finding: Cognitive decline is closely associated with biological aging and with interconnected processes, including chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence. +1 more finding

• Brain Biology

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Public Preferences for End-of-Life Timing in Alzheimer Disease and Related Dementias

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care medRxiv

Key finding: We found that 75% of participants would choose for their life to end in the early stages of ADRD. +3 more findings

• End-of-Life Care

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Fine-Grained Emotional Characterization of Dementia Caregivers in Online Support Communities Using Large Language Models

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving medRxiv

Key finding: Caregiver narratives were predominantly negative (89.3% of posts; mean valence - 0.46), with interpretable structure. +1 more finding

• Caregiving

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Synergistic Interactions of Midlife Multimorbidity on Dementia： A Stratified Analysis by Neuropsychiatric Subtypes

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Specific disease clusters involving diabetes, oral disease, sensory impairment, and osteoporosis were associated with suspected dementia and neuropsychiatric heterogeneity, supporting integrated multimorbidity-oriented screening and care. +3 more findings

• Risk Factors

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Art-based intervention in promoting brain health among the elderly in Okere City, Otuke District, Northern Uganda. A protocol for a Quasi-experimental study

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials Research Square

Key finding: Population ageing is accelerating globally, with a rising burden of neurocognitive disorders such as dementia and Alzheimer’s disease, particularly in low- and middle-income countries. +4 more findings

• Diagnosis

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation with Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: The HELI Randomised Controlled Trial

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials medRxiv

Key finding: We investigated brain, inflammation, cardiometabolic, and gut health changes associated with a six-month multidomain lifestyle intervention in Dutch older adults at risk for cognitive decline and dementia. +4 more findings

• Clinical Trials
• Lifestyle
• Risk Factors

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Early Amyloid-β Toxicity Disrupts Nervous System Connectivity During Aging in Caenorhabditis elegans

16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv

Key finding: Our experiments revealed that nAβ expressing animals exhibit a unique loss of positively correlated neuron connectivity, premature disruption of system wide dynamics, and reduced overall neuronal activity. +1 more finding

• Side Effects

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium

45/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: = 0.039) were associated with better global cognition. +4 more findings

• Risk Factors
• Lifestyle

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Adoption of Medicare's Cognitive Assessment and Care Plan Services Benefit: People, Plans, Payment, and Providers

35/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Through 2022, 5% of fee-for-service beneficiaries with dementia received CACP compared to 3% of MA beneficiaries (p < 0.001). +4 more findings

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Hearing and vision support in people with dementia living at home: Outcomes from the intervention development programme for the European SENSE-Cog Trial

41/100 ✓ Peer-reviewed Digital health tools HRB Open Res

Key finding: This intervention represents the output of the iterative development of a complex intervention to fulfil an unmet need for PwD and sensory loss. +1 more finding

• Clinical Trials

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Building confidence in dementia care: The experience of Chinese Carers in participation in culturally and linguistically appropriate Carer Support Program

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: Four main themes emerged from the data: 1) the unseen challenges of caregiving; 2) knowledge and experiences lead to stronger self-confidence; 3) the power of peer influence on caregiving; and 4) pursuing better support for carers. +4 more findings

• Caregiving

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Co-design, Cultural Adaptation, and Mixed-Methods Evaluation of a Carer Support Program for Chinese Australian Dementia Carers

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: The culturally adapted CSP enhanced self-efficacy among Chinese Australian carers of people with dementia, but not carer burden, quality of life and approach to dementia care. +2 more findings

• Caregiving

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: Traumatic brain injuries (TBIs) are associated with increased risk of neurodegenerative disease, including Alzheimer’s disease (AD); however, the mechanisms by which TBI promotes AD pathogenesis remain poorly understood. +1 more finding

• Risk Factors
• Brain Biology
• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Building Cognitive Lines of Defense: A Life-Course Prevention Strategy for Alzheimer's Disease—An Evidence-Based Multi-Stage Intervention Protocol

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials Research Square

Key finding: AD prevention must transcend the "geriatric disease" mindset.

• Risk Factors
• Prevention

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Computational Screening of 1,348 FDA-Approved Drugs as Potential BACE1 Inhibitors for Alzheimer's Disease Drug Repurposing

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: Of the 1,348 compounds screened, 809 (60%) demonstrated binding affinity below the −7.0 kcal/mol significance threshold. +2 more findings

• Treatments

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: Structured Abstract INTRODUCTION Alzheimer’s disease (AD) progresses over decades, yet plasma biomarkers that resolve disease stage rather than simply detect disease remain scarce. +2 more findings

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Edge-Based ADL Recognition Using Room-Specialized Mixture-of-Experts

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: These findings suggest that room-specialized MoE provides a practical, privacy-preserving framework for continuous smart home monitoring and establishes a foundation for future edgenative healthcare applications, including continual and federated learning.

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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