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C-reactive protein predicts functional decline in older adults newly diagnosed with dementia: A 5-year follow-up study
Miguel Germán Borda, Miguel Germán Borda, Tommy Cederholm, Salomón Salazar‐Londoño, Luis Carlos Venegas‐Sanabria, Hidetaka Wakabayashi, Mario Ulises Pérez-Zepeda, Miguel Fernando Borda et al.. Revista Española de Geriatría y Gerontología, 2025-08-27
Topic: Risk, prevention and care in population studies
A total of 158 participants were included, with an average age of 75.2 years (SD 7.65). 60.8% (n=96) of patients had AD, and 39.2% (n=62) had LBD. Elevated CRP was associated with functional decline during follow-up (Est 0.0118, p-value<0.001). For BMI or weight, we did not find any statistically significant associations, as well as for MMSE, and mortality. Higher CRP levels were associated with greater functional decline in individuals newly diagnosed with dementia.
Key findings
- A total of 158 participants were included, with an average age of 75.2 years (SD 7.65). 60.8% (n=96) of patients had AD, and 39.2% (n=62) had LBD.
- Elevated CRP was associated with functional decline during follow-up (Est 0.0118, p-value<0.001).
- For BMI or weight, we did not find any statistically significant associations, as well as for MMSE, and mortality.
- Higher CRP levels were associated with greater functional decline in individuals newly diagnosed with dementia.
Why it matters
In this 5-year study of 158 people newly diagnosed with dementia, higher CRP levels were linked to greater functional decline. No significant links were found for BMI, weight, MMSE, or mortality.
Study details
- Study designcohort study
- Participants96
- Effect size60.8%; 39.2%
- Evidence strengthModerate
How this study scored 54/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Revista Española de Geriatría y Gerontología) |
| Journal's citation record | 0 / 4 | Revista Española de Geriatría y Gerontología: journal h-index 38 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 96 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Dag Aarsland: h-index 141 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | King's College London: institution h-index 1,348 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 15 institution(s) in 10 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40876302) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.regg.2025.101722
- PubMed: 40876302
- Original source →
- Free full text: Revista Española de Geriatría y Gerontología →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Borda, M. G., Cederholm, T., Salazar‐Londoño, S., Venegas‐Sanabria, L. C., Wakabayashi, H., Pérez-Zepeda, M. U., et al. (2025). C-reactive protein predicts functional decline in older adults newly diagnosed with dementia: A 5-year follow-up study. Revista Española de Geriatría y Gerontología. https://doi.org/10.1016/j.regg.2025.101722
Vancouver
Borda MG, Cederholm T, Salazar‐Londoño S, Venegas‐Sanabria LC, Wakabayashi H, Pérez-Zepeda MU, et al. C-reactive protein predicts functional decline in older adults newly diagnosed with dementia: A 5-year follow-up study. Revista Española de Geriatría y Gerontología. 2025. doi:10.1016/j.regg.2025.101722. PMID: 40876302.
BibTeX
@article{borda2025-40876302,
author = {Borda, Miguel Germán and Cederholm, Tommy and Salazar‐Londoño, Salomón and Venegas‐Sanabria, Luis Carlos and Wakabayashi, Hidetaka and Pérez-Zepeda, Mario Ulises and Borda, Miguel Fernando and others},
title = {{C-reactive protein predicts functional decline in older adults newly diagnosed with dementia: A 5-year follow-up study}},
journal = {Revista Española de Geriatría y Gerontología},
year = {2025},
doi = {10.1016/j.regg.2025.101722},
pmid = {40876302},
url = {https://doi.org/10.1016/j.regg.2025.101722}
}
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