Newest studies

Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study

41/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: The results of our study indicate no reduction in the volume of the hippocampus in patients with major depression. +4 more findings

• Brain Scans

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Practice parameter: risk of driving and Alzheimer's disease (an evidence-based review) [RETIRED]: report of the quality standards subcommittee of the American Academy of Neurology

71/100 ✓ Peer-reviewed Clinical safety Neurology

Key finding: Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. +1 more finding

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Review: modulating factors in amyloid-beta fibril formation

36/100 ✓ Peer-reviewed Clinical safety Journal of structural biology

Key finding: The characteristic amyloid fiber exhibits a high beta-sheet content and may be generated in vitro by the nucleation-dependent self-association of the Abeta peptide and an associated conformational transition from random to beta-conformation. +4 more findings

• Brain Biology

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Survival analysis in percutaneous endoscopic gastrostomy feeding: a worse outcome in patients with dementia

52/100 ✓ Peer-reviewed Clinical safety The American journal of gastroenterology

Key finding: This is the first demonstration in the United Kingdom that the mortality of patients with dementia who are fed by gastrostomy is considerable. +2 more findings

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High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

55/100 ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial.

• Brain Biology

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Voxel-Based Morphometry—The Methods

56/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Voxel-based morphometry (VBM) involves a voxel-wise comparison of the local concentration of gray matter between two groups of subjects. +2 more findings

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Inflammation and Alzheimer's disease

59/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of Aging

Key finding: Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease (AD) brain, and it does so with the full complexity of local peripheral inflammatory responses. +2 more findings

• Brain Biology

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Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia

35/100 ✓ Peer-reviewed Cognitive tests and assessment Psychiatry and clinical neurosciences

Key finding: The cognitive state of each patient was evaluated with the Mini-Mental-State Examination (MMSE) and circadian rhythm with actigram before and after therapy for all of the patients and those of two groups divided by the severity criteria of the Clinical Dementia Rating. +3 more findings

• Diagnosis

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Modelling mini mental state examination changes in Alzheimer's disease

40/100 ✓ Peer-reviewed Cognitive tests and assessment Statistics in medicine

Key finding: While changes over time in the MMSE due to dementia have been studied, the relationship between MMSE scores and the duration of disease course is less well understood. +3 more findings

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Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response

42/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

Key finding: Cognition was measured by means of the global deterioration scale (GDS), the mini mental status examination (MMSE) and a battery of six psychometric tests. +3 more findings

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Proteolytic processing and cell biological functions of the amyloid precursor protein

48/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of cell science

Key finding: Interesting parallels exists with the proteolysis of other proteins involved in cell differentiation, cholesterol homeostasis and stress responses. +1 more finding

• Brain Biology

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On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain & development

Key finding: Resting EEGs from the frontal, central and occipital regions were examined through power spectrum. +4 more findings

• Down Syndrome

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Prevalence of dementia and impact on intellectual disability services

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Mental retardation

Key finding: In a statewide survey, dementia was found in 3% of adults age 40+; 6%, age 60+; and 12%, age 80+. +4 more findings

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Phospholipid composition and levels are altered in Down syndrome brain

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain research

Key finding: Total phospholipid content was significantly reduced approximately 20% in DS frontal cortex and cerebellum relative to these regions in control tissue. +4 more findings

• Down Syndrome

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The rise and fall of frequency and imageability: noun and verb production in semantic dementia

50/100 ✓ Peer-reviewed Digital health tools Brain and language

Key finding: We drew two main predictions from this model: reduced availability of the lower bands of word frequency should result in (a) an apparent deficit for noun retrieval in relation to verb retrieval and (b) an apparent reverse imageability effect. +2 more findings

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Delirium is independently associated with poor functional recovery after hip fracture

63/100 ✓ Peer-reviewed How common it is Journal of the American Geriatrics Society

Key finding: Delirium is common, persistent, and independently associated with poor functional recovery 1 month after hip fracture even after adjusting for prefracture frailty. +2 more findings

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Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group

74/100 ✓ Peer-reviewed Treatments Neurology

Key finding: At 6 months, galantamine significantly improved cognition and global function. +1 more finding

• Clinical Trials
• Treatments

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Differentiating frontal and temporal variant frontotemporal dementia from Alzheimer's disease

52/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: The double dissociation in performance on semantic memory and attention/executive function clearly separated the temporal and frontal variants of FTD and aids the early differentiation of FTD from AD. +2 more findings

• Other Dementias

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Age-specific incidence rates of Alzheimer's disease: the Baltimore Longitudinal Study of Aging

72/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Incidence rates for AD in the BLSA are consistent with published rates in other studies. +1 more finding

• Risk Factors

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The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort

55/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology

Key finding: The "preclinical phase" of detectable lowering of cognitive functioning precedes the appearance of pAD by many years. +1 more finding

• Diagnosis
• Early Stage

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Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4

49/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: Severe CAA confers a greater risk of VLs in AD, even within strata of APOE genotype. +4 more findings

• Genetics
• Risk Factors

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Single and multiple transgenic mice as models for Alzheimer's disease

39/100 ✓ Peer-reviewed Genetics Progress in neurobiology

Key finding: The late development of amyloid plaques in aging transgenic APP mice is needed to warrant that the earlier behavioural and cognitive defects are informative for the human disorder. +4 more findings

• Brain Biology
• Genetics

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Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study

68/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: The APOE*E4 allele of the gene for apolipoprotein E (APOE) has been reported as a risk factor for Alzheimer disease (AD) to varying degrees in different ethnic groups.

• Genetics

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Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD

47/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Mean +/- SD CSF NFL levels were increased in patients with FTD (1442 +/- 1183 pg/mL; p < 0.05) and LAD (1006 +/- 727 pg/mL; p < 0.001) compared with control subjects (241 +/- 166 pg/mL) and in LAD compared with EAD (498 +/- 236 pg/mL; p < 0.05), and tended to be increased in FTD compared with EAD. +4 more findings

• Biomarkers
• Genetics

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Variable expression of familial Alzheimer disease associated with presenilin 2 mutation M239I

41/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology

Key finding: In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source