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On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves
Katada A, Hasegawa S, Ohira D, Kumagai T, Harashima T, Ozaki H, Suzuki H.. Brain & development, 2000-06-01
Topic: Brain proteins, microglia and lab models
The authors tried to know specificity of aging in persons with Down syndrome (DS) from the aspect of electroencephalograph (EEG) frequency changes through the cross-sectional and longitudinal studies, in comparison with normal persons as well as those with mentally retardation except the Down syndrome (non-DS MR). Subjects for a cross-sectional study were 265 persons with DS, 242 with non-DS MR and 239 healthy persons, and subjects for a follow-up study were 28 persons with DS and 14 with non-DS MR, whose EEGs were recorded repeatedly once a year during 8 or 9 years. Resting EEGs from the frontal, central and occipital regions were examined through power spectrum. In the cross-sectional study, the number of subjects with DS who showed dominant component within 8 Hz band of the basic rhythm reached maximum in its appearance rate at 40-44 years of age in the occipital area, but this slowing progressed already at 30-34 years of age. While in non-DS MR, the number of subjects who showed dominant component at 8 Hz reached maximum at 45-49 years of age, and this slowing of the basic rhythm was not so clear as in DS. In the follow-up study for subjects with DS, although the lowering in EEG frequency to 8 Hz took place in various years of age individually, earlier distinct decrease of the frequency was commonly noticed. These earlier steep lowering of EEG frequency was discussed in relation to the senile signs and to the decline of brain function referring to Alzheimer disease.
Key findings
- Resting EEGs from the frontal, central and occipital regions were examined through power spectrum.
- In the cross-sectional study, the number of subjects with DS who showed dominant component within 8 Hz band of the basic rhythm reached maximum in its appearance rate at 40-44 years of age in the occipital area, but this slowing progressed already at 30-34 years of age.
- While in non-DS MR, the number of subjects who showed dominant component at 8 Hz reached maximum at 45-49 years of age, and this slowing of the basic rhythm was not so clear as in DS.
- In the follow-up study for subjects with DS, although the lowering in EEG frequency to 8 Hz took place in various years of age individually, earlier distinct decrease of the frequency was commonly noticed.
- These earlier steep lowering of EEG frequency was discussed in relation to the senile signs and to the decline of brain function referring to Alzheimer disease.
Why it matters
This cross-sectional and follow-up EEG study found that slowing of the basic brain rhythm began earlier in people with Down syndrome than in people with other intellectual disability. It describes a measure of aging in the brain and does not test any treatment, cure, or prevention.
Study details
- Study designcross-sectional
- Participants265
- Evidence strengthModerate
How this study scored 43/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain & development) |
| Journal's citation record | 1 / 4 | Brain and Development: journal h-index 120 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2000 — older than 20 years, still counted |
| Sample size | 2 / 4 | 265 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 28 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 28 year(s) since 2000 |
| Impact for its field and year | 1 / 6 | Cited 0.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Hiroya Suzuki: h-index 12 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Tsukuba: institution h-index 685 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10838108) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Katada, A., Hasegawa, S., Ohira, D., Kumagai, T., Harashima, T., Ozaki, H., et al. (2000). On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves. Brain & development. https://doi.org/10.1016/s0387-7604(00)00107-8
Vancouver
Katada A, Hasegawa S, Ohira D, Kumagai T, Harashima T, Ozaki H, et al. On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves. Brain & development. 2000. doi:10.1016/s0387-7604(00)00107-8. PMID: 10838108.
BibTeX
@article{katada2000-10838108,
author = {Katada, A. and Hasegawa, S. and Ohira, D. and Kumagai, T. and Harashima, T. and Ozaki, H. and Suzuki, H.},
title = {{On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves}},
journal = {Brain \& development},
year = {2000},
doi = {10.1016/s0387-7604(00)00107-8},
pmid = {10838108},
url = {https://doi.org/10.1016/s0387-7604(00)00107-8}
}
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