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Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia
Yamadera H, Ito T, Suzuki H, Asayama K, Ito R, Endo S.. Psychiatry and clinical neurosciences, 2000-06-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Twenty-seven patients with Alzheimer-type dementia (ATD) were treated with bright light therapy in the morning for four consecutive weeks. The cognitive state of each patient was evaluated with the Mini-Mental-State Examination (MMSE) and circadian rhythm with actigram before and after therapy for all of the patients and those of two groups divided by the severity criteria of the Clinical Dementia Rating. The therapy improved the circadian rhythm disturbances.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yamadera, H., Ito, T., Suzuki, H., Asayama, K., Ito, R., & Endo, S. (2000). Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia. Psychiatry and clinical neurosciences. https://doi.org/10.1046/j.1440-1819.2000.00711.x
Vancouver
Yamadera H, Ito T, Suzuki H, Asayama K, Ito R, Endo S. Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia. Psychiatry and clinical neurosciences. 2000. doi:10.1046/j.1440-1819.2000.00711.x. PMID: 11186110.
BibTeX
@article{yamadera2000-11186110,
author = {Yamadera, H. and Ito, T. and Suzuki, H. and Asayama, K. and Ito, R. and Endo, S.},
title = {{Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia}},
journal = {Psychiatry and clinical neurosciences},
year = {2000},
doi = {10.1046/j.1440-1819.2000.00711.x},
pmid = {11186110},
url = {https://doi.org/10.1046/j.1440-1819.2000.00711.x}
}
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Key findings
- The cognitive state of each patient was evaluated with the Mini-Mental-State Examination (MMSE) and circadian rhythm with actigram before and after therapy for all of the patients and those of two groups divided by the severity criteria of the Clinical Dementia Rating.
- The therapy improved the circadian rhythm disturbances.
- Although the therapy caused no remarkable effects on dementia severity, it improved the MMSE scores, especially in the early stages of ATD.
- These results suggest that bright light therapy improved the circadian rhythm disturbances and then bettered the cognitive state in early-stage ATD.
Why it matters
This study treated 27 people with Alzheimer-type dementia with bright light therapy for four weeks and found it improved circadian rhythm disturbances and MMSE scores, especially in early stages, though it caused no remarkable effects on dementia severity. It is a small study of a non-drug therapy, not a cure or prevention.
Study details
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychiatry and clinical neurosciences) |
| Journal's citation record | 1 / 4 | Psychiatry and Clinical Neurosciences: journal h-index 120 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2000 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 151 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.4 citations a year over 28 year(s) since 2000 |
| Impact for its field and year | 2 / 6 | Cited 1.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Shunkichi Endo: h-index 14 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Nippon Medical School: institution h-index 344 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11186110) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 35 / 100 | — |
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