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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,951–12,975 of 27,380 studies, newest first · page 519 of 1096.

April 2019 21

  1. 2019-04-02

    Geographical Variation in the Diagnostic Rate and Quality of Dementia Diagnoses

    ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

    Key finding: The national prevalence and incidence of registered dementia diagnoses was 3.0% and 0.5%, respectively. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-04-02

    Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's Disease on optical coherence tomography angiography

    ✓ Peer-reviewed Cognitive tests and assessment PloS one

    Key finding: Patients with Alzheimer's Disease (AD) exhibit decreased retinal blood flow and vessel density (VD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-04-02

    Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis

    ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of disease

    Key finding: We report effects of low (Curc-lo) and high (Curc-hi) doses of curcumin on neuroinflammation in APPsw transgenic mice. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-04-02

    Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

    ✓ Peer-reviewed Biomarkers Autophagy

    Key finding: We found that autophagy induced by alborixin substantially cleared Aβ in microglia and primary neuronal cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2019-04 month only

    Prescribing physical activity as a preventive measure for middle-aged Australians with dementia risk factors

    ✓ Peer-reviewed Prevention trials Australian journal of primary health

    Key finding: The development of common forms of dementia, including Alzheimer's disease, is associated with lifestyle-related risk factors that are prevalent among middle-aged Australians, including obesity, hypertension, high cholesterol, diabetes and depression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2019-04-01

    Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

    ✓ Peer-reviewed Inflammation and the immune system Nature neuroscience

    Key finding: We found that, in the brains of patients with AD and in AD mouse models, Aβ plaque-associated Olig2- and NG2-expressing oligodendrocyte progenitor cells (OPCs), but not astrocytes, microglia, or oligodendrocytes, exhibit a senescence-like phenotype characterized by the upregulation of p21/CDKN1A, p16/INK4/CDKN2A proteins, and senescence-associated β-galactosidase activity. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-04-01

    Ambient Air Pollution, Noise, and Late-Life Cognitive Decline and Dementia Risk

    ✓ Peer-reviewed Risk factors Annual review of public health

    Key finding: Although current evidence is still limited, especially for chronic noise exposure, high exposure has been associated with faster cognitive decline either mediated through cerebrovascular events or resulting in Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2019-04-01

    Antisense oligonucleotides: A primer

    ✓ Peer-reviewed Drug development Neurology. Genetics

    Key finding: Perhaps the most significant advantage to ASO therapeutics over other small molecule approaches is that acquisition of the target sequence provides immediate knowledge of putative complementary oligonucleotide therapeutics.

    Full summary, score breakdown and related studies → Original source

  9. 2019-04-01

    Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease

    ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

    Key finding: In vitro findings suggest that pathological tau may spread 'prion-like' across neuronal connections in an activity-dependent manner. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-04-01

    The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

    ✓ Peer-reviewed Genetics Cell reports

    Key finding: Activated response microglia (ARMs) are composed of specialized subgroups overexpressing MHC type II and putative tissue repair genes (Dkk2, Gpnmb, and Spp1) and are strongly enriched with Alzheimer's disease (AD) risk genes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-04-01

    Tools Measuring Quality of Death, Dying, and Care, Completed after Death: Systematic Review of Psychometric Properties

    ✓ Peer-reviewed End-of-life care The patient

    Key finding: Four tools demonstrated some promise, but no single tool was consistent across all psychometric properties assessed. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2019-04-01

    Maximizing Annual Wellness Visits to Promote Hearing Health

    ✓ Peer-reviewed Health systems and care delivery The Hearing Journal

    Key finding: Despite the increasing national attention being given to the risks posed by unidentified and untreated hearing loss, stakeholders—including primary care physicians, caregivers, and patients—have yet to make any significant progress in improving earlier recognition of hearing loss. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2019-04-01

    Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia

    ✓ Peer-reviewed Long-term cohort studies Alzheimer disease and associated disorders

    Key finding: We investigated whether cholinesterase inhibitors (ChEIs) benefit cognitive outcomes in mild cognitive impairment due to Alzheimer disease (MCI-AD) and in mild AD dementia (ADdem). +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2019-04-01

    Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease

    ✓ Peer-reviewed Treatments The New England journal of medicine

    Key finding: The drug did not prevent clinical progression in a trial involving patients with mild-to-moderate dementia due to Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2019-04-01

    Immune Signaling in Neurodegeneration

    ✓ Peer-reviewed TREM2 and immune genetics Immunity

    Key finding: Advances in genetics and animal models are beginning to unearth an unexpected role of the immune system in disease onset and pathogenesis; however, the role of cytokines, growth factors, and other immune signaling pathways in disease pathogenesis is still being examined. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2019-04-01

    Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease

    ✓ Peer-reviewed Risk factors JAMA neurology

    Key finding: From a total of 146 patients, 111 patients were included (67 men [60.4%]; mean [SD] age at diagnosis, 62.5 [11.5] years).

    Full summary, score breakdown and related studies → Original source

  17. 2019-04-01

    Longitudinal Relationships Between Decline in Speech-in-Noise Recognition Ability and Cognitive Functioning: The Longitudinal Aging Study Amsterdam

    ✓ Peer-reviewed Digital health tools Journal of speech, language, and hearing research : JSLHR

    Key finding: Causal pathways corresponding to all 4 hypotheses were supported. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2019-04-01

    Long-term outcomes of deep brain stimulation in Parkinson disease

    ✓ Peer-reviewed How common it is Nature reviews. Neurology

    Key finding: Although many patients are lost to follow-up, the evidence indicates that subthalamic nucleus DBS improves motor function for up to 10 years, although the magnitude of improvement tends to decline over time.

    Full summary, score breakdown and related studies → Original source

  19. 2019-04-01

    The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies

    ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

    Key finding: Our main findings were: (i) FDG-PET uptake in the bilateral anterior cingulate cortex and anterior temporal pole was associated with baseline global cognition in cognitively stable 80+ (the resilience signature); (ii) established Alzheimer's disease imaging biomarkers did not predict baseline global cognition in this subset of participants; (iii) in the full MCSA 80+ and ADNI cohorts, amyloid burden and FDG-PET in the resilience signature were the stronger predictors of baseline global cognition; (iv) sex and systemic vascular health predicted FDG-PET in the resilience signature, suggesting vascular health maintenance as a potential pathway to preserve the metabolism of these areas; and (v) the resilience signature provided significant information about global longitudinal cognitive change even when considering amyloid status in both the MCSA and ADNI cohorts.

    Full summary, score breakdown and related studies → Original source

  20. 2019-04-01

    Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers

    ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

    Key finding: Symptomatic mutation carriers also demonstrated elevated tau PET binding in the basal ganglia, consistent with prior work with amyloid-β. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2019-04-01

    Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

    ✓ Peer-reviewed Biomarkers JAMA

    Key finding: Among 16 008 registered participants, 11 409 (71.3%) completed study procedures and were included in the analysis (median age, 75 years [interquartile range, 71-80]; 50.9% women; 60.5% with MCI). +4 more findings

    Full summary, score breakdown and related studies → Original source

March 2019 4

  1. 2019-03-31

    The Pharmacy Combining Convenience Store with Care Consulting Services

    ✓ Peer-reviewed Risk factors YAKUGAKU ZASSHI

    Key finding: Dispensing pharmacy stores-pharmacies that combine the features of a convenience store with care consulting services-were established in 2016. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-03-30

    Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

    ✓ Peer-reviewed Long-term cohort studies Journal of neuroinflammation

    Key finding: Immunity has been suggested to be important in the pathogenesis of dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-03-29

    Effect of Patients' Life Stories in Bringing Meaning to Nursing Home Care

    ✓ Peer-reviewed Health systems and care delivery PRiMER (Leawood, Kan.)

    Key finding: Participants found nursing home care challenging, particularly for patients who were nonverbal due to advanced dementia, because they had difficulties forming meaningful relationships or discussing medical decisions with their patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-03-29

    Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP

    ✓ Peer-reviewed Biomarkers Scientific reports

    Key finding: Here, we investigate the impact of the I45T mutation on the backbone dynamics of the substrate TMD. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →