Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,076–26,100 of 27,380 studies, newest first · page 1044 of 1096.
October 1997 14
-
1997-10-01
Meta-analysis of the Hachinski Ischemic Score in pathologically verified dementias
79/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: The mean HIS (+/- SD) was 5.4 +/- 4.5 and differed significantly among the groups (AD, 3.1 +/- 2.5; MID, 10.5 +/- 4.1; mixed, 7.7 +/- 4.3). +3 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease
52/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Neuropathology & Experimental Neurology
Full summary, score breakdown and related studies → Original source
-
1997-10-01
The need for research on dementia in developing countries
37/100 ✓ Peer-reviewed Risk factors Tropical Medicine & International Health
Key finding: Although most older people live in developing countries, little research has been carried out in those settings. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons
40/100 ✓ Peer-reviewed Inflammation and the immune system The American journal of pathology
Key finding: CXCR-4 (fusin) was the first identified, and it serves as co-receptor for T-cell-line tropic (T-tropic) HIV-1 isolates. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Subjective memory complaints in the elderly: depressive symptoms and future dementia
47/100 ✓ Peer-reviewed Cognitive tests and assessment The British journal of psychiatry : the journal of mental science
Key finding: Population studies indicate that subjective memory complaints by elderly people are correlated with cognitive performance. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Left ventricular dysfunction: a clue to cognitive impairment in older patients with heart failure
41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: Cognitive impairment has been reported in middle aged patients with end stage heart failure. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
53/100 ✓ Peer-reviewed Risk genes beyond APOE Neuron
Key finding: In a variety of experimental in vitro and in vivo settings, FAD-linked presenilin variants influence the processing of the amyloid precursor protein (APP), leading to elevated levels of the highly fibrillogenic Abeta1-42 peptides that are preferentially deposited in the brains of Alzheimer Disease (AD) patients. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
[The apolipoprotein E genotype and Down's syndrome]
27/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Revista clinica espanola
Key finding: Dementia in Alzheimer disease has been associated with the presence of genotype epsilon 4/epsilon 4 in apolipoprotein E (apo E). +1 more finding
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Evidence against increased oxidative DNA-damage in Down syndrome
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters
Key finding: We measured the oxidized nucleoside, 8-hydroxy-2'-deoxyguanosine (8-OHdG), in nuclear DNA (nDNA) isolated from four different regions of cerebral cortex and cerebellum in 10 adult DS and 10 Alzheimer's disease (AD) patients compared to normal controls. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society
53/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Alzheimer disease is progressive and irreversible, but pharmacologic therapies for cognitive impairment and nonpharmacologic and pharmacologic treatments for the behavioral problems associated with dementia can enhance quality of life.
Full summary, score breakdown and related studies → Original source
-
1997-10-01
A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group
76/100 ✓ Peer-reviewed Treatments JAMA
Key finding: EGb was safe and appears capable of stabilizing and, in a substantial number of cases, improving the cognitive performance and the social functioning of demented patients for 6 months to 1 year. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice
42/100 ✓ Peer-reviewed Genetics Human molecular genetics
Key finding: Expression of SOD1 transgenes is protective, suggesting involvement of oxidative damage in premature death, but ablation of Apoe had no significant effect.
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
53/100 ✓ Peer-reviewed Genetics JAMA
Key finding: Fifteen chromosomal regions warranted initial follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1997-10-01
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
70/100 ✓ Peer-reviewed Genetics JAMA
Key finding: Among Caucasian subjects from clinic- or autopsy-based studies, the risk of AD was significantly increased for people with genotypes epsilon2/epsilon4 (OR=2.6, 95% CI=1.6-4.0), epsilon3/epsilon4 (OR=3.2, 95% CI=2.8-3.8), and epsilon4/epsilon4 (OR=14.9, 95% CI= 10.8-20.6); whereas, the ORs were decreased for people with genotypes epsilon2/epsilon2 (OR=0.6, 95% CI=0.2-2.0) and epsilon2/epsilon3 (OR=0.6, 95% CI=0.5-0.8). +1 more finding
Full summary, score breakdown and related studies → Original source
September 1997 10
-
1997-09-15
Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
36/100 ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience Research
Key finding: We conclude that, by inducing production of Mn-SOD and suppressing peroxynitrite formation and membrane lipid peroxidation, NF-kappaB plays an anti-apoptotic role in neurodegenerative conditions that involve oxidative stress.
Full summary, score breakdown and related studies → Original source
-
1997-09-13
Bias in meta-analysis detected by a simple, graphical test
57/100 ✓ Peer-reviewed How common it is BMJ
A simple analysis of funnel plots provides a useful test for the likely presence of bias in meta-analyses, but as the capacity to detect bias will be limited when meta-analyses are based on a limited number of small trials the results from such analyses should be treated with considerable caution.
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Cell
Key finding: Although structural features indicate that the presenilins are membrane proteins, their function(s) is unknown. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Medically recognized urinary incontinence and risks of hospitalization, nursing home admission and mortality
45/100 ✓ Peer-reviewed Vascular contributions Age and ageing
Key finding: Design review and abstraction of medical records and computerized data bases from 5986 members, aged 65 years and older, of a large health maintenance organization in northern California.
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Factors influencing dialysis patients' completion of advance directives
43/100 ✓ Peer-reviewed End-of-life care American journal of kidney diseases : the official journal of the National Kidney Foundation
Key finding: Those who did not complete the dialysis-specific living will chose not to because they were not sure what they would want done (12 of 16 patients [75%]). +4 more findings
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Criteria for enrolling dementia patients in hospice
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Our hospice enrollment criteria identified a group with a median survival time of 4 months and a mean survival time of 6.9 months. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides
55/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine
Key finding: Proteolysis by gamma-secretase is the last processing step resulting in release of A beta. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1997-09-01
A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
48/100 ✓ Peer-reviewed Lewy body dementia Journal of neurochemistry
Key finding: In brain areas associated with PD, such as substantia nigra, caudate nucleus, and putamen, there was a significant increase in carbonyl levels. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Developmental immunohistochemistry of growth inhibitory factor in normal brains and brains of patients with Down syndrome
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Pediatric neurology
Key finding: Therefore, growth inhibitory factor in astrocytes may be correlated with dendritic maturation of neurons. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1997-09-01
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
57/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The volume of each MTL structure was significantly smaller in AD patients than control subjects (p < 0.001).
Full summary, score breakdown and related studies → Original source
August 1997 1
-
1997-08-28
α-Synuclein in Lewy bodies
60/100 ✓ Peer-reviewed Lewy body dementia Nature
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →