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Modelling mini mental state examination changes in Alzheimer's disease
Mendiondo MS, Ashford JW, Kryscio RJ, Schmitt FA.. Statistics in medicine, 2000-06-01
Topic: Amyloid, tau and blood-test diagnosis
The Mini Mental State Examination (MMSE) is widely used to measure dementia severity in Alzheimer's disease patients. While changes over time in the MMSE due to dementia have been studied, the relationship between MMSE scores and the duration of disease course is less well understood. Using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) data, we modelled change in MMSE as a function of time for this population.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Mendiondo, M. S., Ashford, J. W., Kryscio, R. J., & Schmitt, F. A. (2000). Modelling mini mental state examination changes in Alzheimer's disease. Statistics in medicine. https://doi.org/10.1002/(sici)1097-0258(20000615/30)19:11/12<1607::aid-sim449>3.0.co;2-o
Vancouver
Mendiondo MS, Ashford JW, Kryscio RJ, Schmitt FA. Modelling mini mental state examination changes in Alzheimer's disease. Statistics in medicine. 2000. doi:10.1002/(sici)1097-0258(20000615/30)19:11/12<1607::aid-sim449>3.0.co;2-o. PMID: 10844722.
BibTeX
@article{mendiondo2000-10844722,
author = {Mendiondo, M. S. and Ashford, J. W. and Kryscio, R. J. and Schmitt, F. A.},
title = {{Modelling mini mental state examination changes in Alzheimer's disease}},
journal = {Statistics in medicine},
year = {2000},
doi = {10.1002/(sici)1097-0258(20000615/30)19:11/12<1607::aid-sim449>3.0.co;2-o},
pmid = {10844722},
url = {https://doi.org/10.1002/(sici)1097-0258(20000615/30)19:11/12<1607::aid-sim449>3.0.co;2-o}
}
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Key findings
- While changes over time in the MMSE due to dementia have been studied, the relationship between MMSE scores and the duration of disease course is less well understood.
- Using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) data, we modelled change in MMSE as a function of time for this population.
- For this purpose we used the interval between consecutive MMSE assessments as the time factor.
- We also investigated the impact of sex, education and age at testing on the resulting model.
Why it matters
Using registry data, this study modelled how MMSE scores change over time in Alzheimer's disease patients and examined the influence of sex, education and age at testing. It concerns describing disease progression on a test and does not address treating, curing or preventing Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Statistics in medicine) |
| Journal's citation record | 3 / 4 | Statistics in Medicine: journal h-index 309 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2000 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 153 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.5 citations a year over 28 year(s) since 2000 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Frederick A. Schmitt: h-index 83 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Kentucky: institution h-index 824 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10844722) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/(sici)1097-0258(20000615/30)19:11/12<1607::aid-sim449>3.0.co;2-o
- PubMed: 10844722
- Original source →
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