Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,201–24,225 of 27,380 studies, newest first · page 969 of 1096.
March 2004 5
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2004-03-01
Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease
45/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Informant- and self-perceptions of QOL differed substantially. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
The Rowland Universal Dementia Assessment Scale (RUDAS): a multicultural cognitive assessment scale
59/100 ✓ Peer-reviewed Getting a diagnosis International psychogeriatrics
Key finding: The 6-item RUDAS is portable and tests multiple cognitive domains. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-03-01
Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins
62/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: This study questions the effect of statins on the processing of amyloid precursor protein in humans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
40/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Double-labeling with AT8 and anti-GFAP antibodies demonstrated that the abnormal tau protein was deposited in astroglial cell bodies and in proximal and distal astroglial processes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
57/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: These data support distinct processes in the initiation and progression of AD pathology within the temporal cortex: Deposition of Abeta reaches a "ceiling" early in the disease process, whereas NFT formation, synaptic loss, and gliosis continue throughout the course of the illness.
Full summary, score breakdown and related studies → Original source
February 2004 20
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2004-02-24
Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Furthermore, inhibition of mitosis-related cyclin-dependent kinases (Cdks) by roscovitine significantly reduced the hyperphosphorylation of tau. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-02-15
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
36/100 ✓ Peer-reviewed Risk factors Proceedings of the National Academy of Sciences of the United States of America
Key finding: The pathogenesis of AD is tightly linked to Abeta deposition and oxidative stress, but it remains unclear as to how these factors result in neuronal dysfunction and death. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-11
Deaths: preliminary data for 2002
36/100 ✓ Peer-reviewed Risk factors PubMed
Key finding: The age-adjusted death rate in 2002 for the United States decreased from 854.5 deaths per 100,000 population in 2001 to 846.8 in 2002. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-09
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses
43/100 ✓ Peer-reviewed Cognitive tests and assessment Proceedings of the National Academy of Sciences of the United States of America
Key finding: These well powered tests revealed a major transcriptional response comprising thousands of genes significantly correlated with AD markers. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-06
Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation
41/100 ✓ Peer-reviewed Treatments Proceedings of the National Academy of Sciences of the United States of America
Key finding: These findings are in line with predictions that a low cholinergic tone during SWS is essential for declarative memory consolidation.
Full summary, score breakdown and related studies → Original source
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2004-02-05
Brain cholesterol: long secret life behind a barrier
36/100 ✓ Peer-reviewed Risk factors Arteriosclerosis, thrombosis, and vascular biology
Key finding: This oxysterol is capable of escaping the recycling mechanism and traversing the blood-brain barrier. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-04
Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: α-Synuclein
36/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the American Chemical Society
Key finding: The application of Raman spectroscopy to characterize natively unfolded proteins has been underdeveloped, even though it has significant technical advantages. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-02-04
What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
47/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: We found significant naming deficits in all patient groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-01
Disclosing a diagnosis of dementia: a systematic review
57/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Existing evidence regarding diagnostic disclosure in dementia is both inconsistent and limited with the perspectives of people with dementia being largely neglected.
Full summary, score breakdown and related studies → Original source
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2004-02-01
Increased risk of type 2 diabetes in Alzheimer disease
48/100 ✓ Peer-reviewed Risk factors Diabetes
Key finding: To address this, we first examined the prevalence of type 2 diabetes in a community-based controlled study, the Mayo Clinic Alzheimer Disease Patient Registry (ADPR), which follows patients with Alzheimer disease versus control subjects without Alzheimer disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-02-01
The glamour and gloom of glycogen synthase kinase-3
36/100 ✓ Peer-reviewed Risk factors Trends in biochemical sciences
Key finding: Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly large number of cellular processes and diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-01
Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications
40/100 ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology
Key finding: Genomic triplication of the alpha-synuclein gene recently has been associated with familial Parkinson's disease in the Spellman-Muenter kindred.
Full summary, score breakdown and related studies → Original source
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2004-02-01
Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia
47/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: A 1-minute semantic fluency test can assist in early detection of dementia in the memory clinic setting. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-01
Hippocampal volume and memory performance in a community-based sample of women with posttraumatic stress disorder secondary to child abuse
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of traumatic stress
Key finding: Women with PTSD did not express significant deficits in memory performance or hippocampal volume when compared with the abuse and normal control groups.
Full summary, score breakdown and related studies → Original source
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2004-02-01
Medicare program expenditures associated with hospice use
67/100 ✓ Peer-reviewed End-of-life care Annals of internal medicine
Key finding: Hospice enrollment correlates with reduced Medicare expenditures among younger decedents with cancer but increased expenditures among decedents without cancer and those older than 84 years of age. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-02-01
Dying with advanced dementia in the nursing home
50/100 ✓ Peer-reviewed End-of-life care Archives of internal medicine
Key finding: Nursing home residents dying with advanced dementia are not perceived as having a terminal condition, and most do not receive optimal palliative care.
Full summary, score breakdown and related studies → Original source
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2004-02-01
Pneumonia in the very old
36/100 ✓ Peer-reviewed Clinical safety The Lancet. Infectious diseases
Key finding: Although there are no fundamental differences in pathophysiology and microbiology of the two entities, NHAP tends to be much more severe, because milder cases are not referred to the hospital, and residents of nursing homes often suffer from dementia, multiple comorbidities, and decreased functional status. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-01
Individual analysis of EEG frequency and band power in mild Alzheimer's disease
46/100 ✓ Peer-reviewed Cognitive tests and assessment Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: This EEG study investigates the role of the cholinergic system, cortico-cortical connections, and sub-cortical white matter on the relationship between individual EEG frequencies and their relative power bands. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-01
Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy--PLOSL): a dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects
41/100 ✓ Peer-reviewed TREM2 and immune genetics Cellular and molecular neurobiology
Key finding: Nasu-Hakola disease is a unique disease characterized by multiple bone cysts associated with a peculiar form of neurodegeneration that leads to dementia and precocious death usually during the fifth decade of life. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-02-01
Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease
38/100 ✓ Peer-reviewed Risk genes beyond APOE Current protein & peptide science
Key finding: This binding has been studied as regards the direct toxicity of Abeta on neurons, and the activation of a local inflammation phase involving microglia. +3 more findings
Full summary, score breakdown and related studies → Original source
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