Newest studies

A 26-week analysis of a double-blind, placebo-controlled trial of the ginkgo biloba extract EGb 761 in dementia

59/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders

Key finding: The data were collected during a 52-week, double-blind, placebo-controlled, fixed dose, parallel-group, multicenter study. +3 more findings

• Clinical Trials

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Treatment of cognitive impairment after poststroke depression : a double-blind treatment trial

45/100 ✓ Peer-reviewed Cognitive tests and assessment Stroke

Key finding: Patients with poststroke major depression have a greater severity of cognitive impairment than nondepressed patients even when matched for size and location of stroke lesion. +3 more findings

• Clinical Trials
• Treatments

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Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss

49/100 ✓ Peer-reviewed Risk genes beyond APOE The American journal of pathology

Key finding: Deposition of Abeta was detected as early as 3 months of age in the Fc and CA1 of PSAPP mice and progressed to cover 28.3% of the superior frontal cortex and 18.4% of CA1 at 12 months: approximately 20- (Fc) and approximately 40- (CA1) fold greater deposition than in APPsw mice. +3 more findings

• Brain Biology
• Genetics

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Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study

56/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: These findings suggest that the initial 1H MRS change in the pathologic progression of AD is an increase in MI/Cr. +3 more findings

• Early Stage

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

56/100 ✓ Peer-reviewed Lewy body dementia Nature genetics

Key finding: Our findings indicate that accumulation of proteins that have yet to be identified causes a selective neural cell death without formation of Lewy bodies. +1 more finding

• Genetics
• Other Dementias

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Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL

44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: We have previously shown that Alzheimer disease (AD) brain exhibits terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) for DNA damage and morphological evidence for apoptosis. +4 more findings

• Down Syndrome
• Brain Biology

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Are hereditary hemochromatosis mutations involved in Alzheimer disease?

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics

Key finding: Mutations in the class I-like major histocompatibility complex gene called HFE are associated with hereditary hemochromatosis (HHC), a disorder of excessive iron uptake. +2 more findings

• Genetics

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Is depression a risk factor for dementia or cognitive decline? A review

63/100 ✓ Peer-reviewed Risk factors Gerontology

Key finding: There is sufficient evidence to take seriously the possibility that depression is a risk factor for dementia and cognitive decline. +1 more finding

• Risk Factors

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The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong

32/100 ✓ Peer-reviewed Digital health tools Annals of the Academy of Medicine, Singapore

Key finding: The internal consistency (Cronbach's alpha) of the ADAS-cog were 0.91, 0.88 and 0.65 for the whole group, the AD and normal (i.e. non-demented) subjects respectively.

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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

53/100 ✓ Peer-reviewed How common it is Nature genetics

Key finding: We have previously identified a shared 153-kb ancestor haplotype in all Finnish disease alleles between markers D19S1175 and D19S608 on chromosome 19q13.1 (refs 5,6). +4 more findings

• Genetics

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Barriers to healthcare access for cognitively impaired older Hispanics

36/100 ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders

Key finding: This study further reports the results of the BHAS applied to a community sample of cognitively impaired older Hispanics and their caregivers. +1 more finding

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Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients

54/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: Patients with anti-Ta (also called anti-Ma2) antibodies were young men with testicular tumours (100%), frequent hypothalamic involvement (70%) and a poor neurological outcome. +4 more findings

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Vascular dementia : incidence and risk factors in the Canadian study of health and aging

64/100 ✓ Peer-reviewed Prevention and risk Stroke

Key finding: The study confirmed some previously reported risk factors but also suggested new ones. +2 more findings

• Risk Factors
• Other Dementias

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Cognitive impairment without dementia in older people: prevalence, vascular risk factors, impact on disability. The Italian Longitudinal Study on Aging

60/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society

Key finding: CIND is very frequent in older people. +3 more findings

• Risk Factors

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Efficacy of naftidrofuryl in patients with vascular or mixed dementia: results of a multicenter, double-blind trial

52/100 ✓ Peer-reviewed Treatments Clinical therapeutics

Key finding: The results of this study suggest that naftidrofuryl is effective and well tolerated in treating the symptoms of vascular and mixed dementia. +3 more findings

• Clinical Trials
• Diagnosis
• Other Dementias

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

52/100 ✓ Peer-reviewed Genetics The American journal of pathology

Key finding: To evaluate endocytic activation, we used markers of internalization (rab5, rabaptin 5) and recycling (rab4), and found that enlargement of rab5-positive early endosomes in the AD brain was associated with elevated levels of rab4 immunoreactive protein and translocation of rabaptin 5 to endosomes, implying that both endocytic uptake and recycling are activated. +2 more findings

• Genetics
• Brain Biology
• Down Syndrome

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Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

40/100 ✓ Peer-reviewed Biomarkers International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Key finding: To elucidate the mechanisms involved in beta-amyloid-mediated inflammation, transgenic mice (Tg2576) expressing high levels of the Swedish double mutation of human amyloid precursor protein and progressively developing typical beta-amyloid plaques in cortical brain regions including gliosis and astrocytosis, were examined for the expression pattern of a number of cytokines. +4 more findings

• Brain Biology

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SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease

48/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: Our results demonstrate that associations can be detected at SNPs near a complex disease gene. +1 more finding

• Genetics

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Clock-drawing: is it the ideal cognitive screening test?

36/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: The clock-drawing test meets defined criteria for a cognitive screening instrument. +3 more findings

• Diagnosis

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How much do persons with Alzheimer's disease cost Medicare?

55/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

Key finding: The average total cost to Medicare of persons with a claims-based diagnosis of AD was $6021 versus $2310 (P < .001) for persons without a diagnosis. +1 more finding

• Policy

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On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

36/100 ✓ Peer-reviewed End-of-life care Experimental neurology

Key finding: Bartus, Simple Words for Complex Lives, (c) 1998 In the nearly 20 years since the cholinergic hypothesis was initially formulated, significant progress has been achieved. +1 more finding

• Treatments

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Inflamm-aging. An evolutionary perspective on immunosenescence

36/100 ✓ Peer-reviewed Risk factors Annals of the New York Academy of Sciences

Key finding: In conclusion, the beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

41/100 ✓ Peer-reviewed Risk genes beyond APOE Nature

Key finding: There is evidence that the polytopic membrane-spanning proteins, presenilin 1 and 2 (PS1 and PS2), are important determinants of gamma-secretase activity: mutations in PS1 and PS2 that are associated with early-onset familial Alzheimer's disease increase the production of A beta42 (refs 4-6), the more amyloidogenic peptide; gamma-secretase activity is reduced in neuronal cultures derived from PS1-deficient mouse embryos; and directed mutagenesis of two conserved aspartates in transmembrane segments of PS1 inactivates the ability of gamma-secretase to catalyse processing of APP within its transmembrane domain. +2 more findings

• Genetics
• Brain Biology

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From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of the New York Academy of Sciences

Key finding: More importantly, the right EC, but not the left, was significantly smaller in elderly participants compared to young controls. +2 more findings

• Brain Scans

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Hippocampal volume and everyday memory in children of very low birth weight

41/100 ✓ Peer-reviewed Hippocampus size on brain scans Pediatric research

Key finding: The preterm group had significantly smaller hippocampal volumes bilaterally, despite equivalent head size, and showed specific deficits in certain aspects of everyday memory, both on objective testing and as indicated by parental questionnaires.

• Brain Scans

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