Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,951–22,975 of 27,380 studies, newest first · page 919 of 1096.
October 2006 12
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2006-10-01
Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study
59/100 ✓ Peer-reviewed Mild cognitive impairment The Lancet. Neurology
Key finding: Mutation carriers had significantly increased hippocampal and whole-brain atrophy rates compared with controls and these differences increased with time. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-10-01
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery
49/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Classic Parkinson's disease (PD) is characterized by fibrillar alpha-synuclein inclusions known as Lewy bodies in the substantia nigra, which are associated with nigrostriatal degeneration.
Full summary, score breakdown and related studies → Original source
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2006-10-01
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
62/100 ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)
Key finding: Although the identity of the ubiquitinated protein specific to either disorder was unknown, we showed that TDP-43 is the major disease protein in both disorders.
Full summary, score breakdown and related studies → Original source
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2006-10-01
Prevalence of dementia in rural China: impact of age, gender and education
55/100 ✓ Peer-reviewed Disparities Acta neurologica Scandinavica
Key finding: The prevalence of dementia in this population is similar to that reported from other areas in mainland China and Taiwan with aging being a significant risk factor. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-10-01
Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment
48/100 ✓ Peer-reviewed Disparities Journal of neurovirology
Key finding: Human immunodeficiency virus (HIV)-associated cognitive impairment, a significant cause of morbidity, affects up to 30% of HIV-infected people. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-10-01
Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
56/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Frontotemporal dementia and Alzheimer disease display different spatial distributions of hypoperfusion on arterial spin labeling MRI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-10-01
Comparison of three rating scales as outcome measures for treatment trials of depression in Alzheimer disease: findings from DIADS
58/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry
Key finding: The CSDD, and particularly its mood subscale, appears to be more sensitive than the HDRS, it's subscales or the NPI-M, for comparing drug to placebo in treating major depression in AD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-10-01
Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis
58/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: These post-hoc analyses support the beneficial effects of memantine on cognition observed in a previously reported clinical trial. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-10-01
Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment
59/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: In moderate-to-severe Alzheimer disease (AD), there are significant losses of activities of daily living (ADL). +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-10-01
ADCS Prevention Instrument Project: overview and initial results
61/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: This initial report describes the ongoing 4-year longitudinal study and provides baseline results, which confirm the feasibility of obtaining home-based clinical information via mail or telephone. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-10-01
Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
71/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: One hundred seventy-four patients fulfilled the trial. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-10-01
Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
41/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology
Key finding: In homogenates of the frontal cortex, NEP protein levels were reduced in AD but not significantly; NEP enzymatic activity was significantly reduced in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
September 2006 13
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2006-09-29
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
51/100 ✓ Peer-reviewed Tau biomarkers Brain
Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2006-09-29
The relationship between cerebral Alzheimer's disease pathology and odour identification in old age
56/100 ✓ Peer-reviewed Caregiving Journal of neurology, neurosurgery, and psychiatry
Key finding: The results suggest that difficulty in identifying familiar odours in old age is partly due to the accumulation of neurofibrillar pathology in central olfactory regions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-29
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice
45/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: We found significantly higher levels of membrane-associated Abeta42 in the hippocampus of mice that overexpressed mLRP2. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-28
Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease
51/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: The thickness of the cortex decreased significantly when the healthy elderly brains were compared to those with MCI, mainly in the medial temporal lobe region and in some regions of the frontal and the parietal cortices. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-28
Structural anatomy of empathy in neurodegenerative disease
58/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology
Key finding: Voxels in the right temporal pole, the right fusiform gyrus, the right caudate and right subcallosal gyrus correlated significantly with total empathy score (P < 0.05 after whole-brain correction for multiple comparisons). +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-28
A systematic review of the prevalence and covariates of anxiety in caregivers of people with dementia
59/100 ✓ Peer-reviewed Caregiving International psychogeriatrics
Key finding: Coping style may be more associated with anxiety than depression while other covariates (burden and poor physical health) are similar to those for caregiver depression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-27
Selection and characterization of Affibody ligands binding to Alzheimer amyloid beta peptides
38/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of biotechnology
Key finding: Post-selection screening of 384 randomly picked clones, out of which 192 clones were subjected to DNA sequencing and clustering, resulted in the identification of 16 Affibody variants that were produced and affinity purified for ranking of their binding properties. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-27
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD
46/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuroinflammation
Key finding: Microglia are associated with neuritic plaques in Alzheimer disease (AD) and serve as a primary component of the innate immune response in the brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-26
Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
50/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica
Key finding: The influence of histological type on clinical phenotype was highly significant with type 1 histology being associated clinically with cases of frontotemporal dementia (FTD) or progressive non-fluent aphasia (PNFA), type 2 histology with semantic dementia (SD), and type 3 histology with FTD, or FTD and motor neurone disease (MND).
Full summary, score breakdown and related studies → Original source
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2006-09-25
Resting state oscillatory brain dynamics in Parkinson's disease: an MEG study
36/100 ✓ Peer-reviewed Brain scans and imaging Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: Parkinson's disease is characterized by a slowing of resting state brain activity involving theta, beta and gamma frequency bands. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-25
Increased fMRI responses during encoding in mild cognitive impairment
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging
Key finding: Compared to controls, the MCI subjects exhibited increased fMRI responses in the posterior hippocampal, parahippocampal and fusiform regions, while VBM revealed more atrophy in MCI in the anterior parts of the left hippocampus. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-21
Control of peripheral nerve myelination by the beta-secretase BACE1
41/100 ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)
Key finding: We found that very high levels of BACE1 were expressed at time points when peripheral nerves become myelinated.
Full summary, score breakdown and related studies → Original source
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2006-09-20
Test performance and classification statistics for the Rey Auditory Verbal Learning Test in selected clinical samples
43/100 ✓ Peer-reviewed Vascular contributions Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Key finding: Patients were stratified into three age groups, 16-35, 36-59, and 60-88. +4 more findings
Full summary, score breakdown and related studies → Original source
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