Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,701–26,725 of 27,380 studies, newest first · page 1069 of 1096.
January 1994 12
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1994-01-01
Expression of alpha B-crystallin in Alzheimer's disease
40/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica
Key finding: Under pathological conditions, the expression of alpha B-crystallin increases in proliferating astrocytes, which suggests that this protein, in addition to glial fibrillary acidic protein (GFAP), can be a marker for gliosis in neurodegenerative diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
MRI-based hippocampal volume measurements in epilepsy
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Epilepsia
Key finding: Abnormalities in hippocampal morphology, including unilateral or bilateral volume loss, are known to occur in epilepsy, Alzheimer's disease, and in certain amnestic syndromes. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
The relative contributions of MRI, SPECT, and PET imaging in epilepsy
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Epilepsia
Key finding: Only magnetic resonance imaging (MRI) can image the structural changes associated with the underlying epileptic process, and quantitative evidence of hippocampal volume loss has been highly correlated with seizure onset in medial temporal structures.
Full summary, score breakdown and related studies → Original source
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1994-01-01
Cellular forms and functions of brain microglia
41/100 ✓ Peer-reviewed Inflammation and the immune system Brain research bulletin
Key finding: The microglia are derived from blood monocytes that migrate into the tissue during fetal development and subsequently remain after complete formation of the blood-brain barrier. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans
46/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica
Key finding: In demented subjects of 80 years of age or older, the frequency of HpScl was even higher, 26%. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
53/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica
Key finding: For the purpose of correlation, the two methods are carried out one after the other on the same section. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
Severe impairment battery. A neuropsychological test for severely demented patients
55/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of neurology
Key finding: Patients with progressive dementia invariably evolve to a stage where they can no longer be tested by standard neuropsychological tests. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
The rate of the Down syndrome among offspring of women with Alzheimer disease
26/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Psychiatric genetics
Key finding: It has been reported that the Down syndrome occurs more often than expected among relatives of individuals with Alzheimer disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
Prevalence and pattern of major neurological disorders in rural Kashmir (India) in 1986
35/100 ✓ Peer-reviewed Disparities Neuroepidemiology
Key finding: In 1986 in the Kuthar Valley in the Anantnag District of south Kashmir (northwestern India), we studied the population to ascertain the prevalence and pattern of various neurological diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-01-01
Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial
52/100 ✓ Peer-reviewed Disparities Neurology
Key finding: These we compared with 223 unimpaired, unmatched controls from the same population for exposure to familial, cardiovascular, educational, and geographic risk factors for dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-01-01
Measuring preferences for health states worse than death
59/100 ✓ Peer-reviewed Caregiving Medical decision making : an international journal of the Society for Medical Decision Making
Key finding: Previous research indicates that persons assigning values to ranges of health states consider some states to be worse than death. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-01-01
Antagonic-stress superiority versus meclofenoxate in gerontopsychiatry (alzheimer type dementia)
29/100 ✓ Peer-reviewed Treatments Archives of gerontology and geriatrics
Key finding: Prolonged treatments with MF and AS significantly decreased the psychogeriatric scores in scales and subscales, improved the cognitive performance (attention, concentration, memory, performance IQ, full IQ) and diminshed the deterioration index (ANOVA). +2 more findings
Full summary, score breakdown and related studies → Original source
December 1993 8
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1993-12-01
An Intervention That Delays Institutionalization of Alzheimer's Disease Patients: Treatment of Spouse-Caregivers
38/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: This suggests that a comprehensive counseling program can reduce the socioeconomic impact of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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1993-12-01
The consortium to establish a registry for Alzheimer's disease (CERAD). Part IV. Rates of cognitive change in the longitudinal assessment of probable Alzheimer's disease
48/100 ✓ Peer-reviewed Health systems and care delivery Neurology
Key finding: We found that rate-of-change determinations are less reliable when the observation period is 1 year or less, that dementia progression may be nonlinear when described by certain measures, and that simple change scores do not accurately characterize the rate of decline.
Full summary, score breakdown and related studies → Original source
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1993-12-01
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
36/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America
Key finding: Electron microscopic analysis demonstrated that the immunostaining was localized on amyloid fibrils. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-12-01
Driving and Alzheimer's disease: the risk of crashes
40/100 ✓ Peer-reviewed Clinical safety Neurology
Key finding: We designed this questionnaire-based study to determine the risk of auto crashes among Alzheimer's disease (AD) patients who continued to drive after the onset of AD, compared with normal age-matched control subjects and other drivers' statistical records. +2 more findings
Full summary, score breakdown and related studies → Original source
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1993-12-01
pH-dependent binding of synthetic beta-amyloid peptides to glycosaminoglycans
38/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: The latter has been shown recently to bind tightly to both amyloid precursor protein and A beta, and this binding has been attributed largely to the interaction of the core protein of heparan sulfate proteoglycan with A beta and its precursor. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-12-01
apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor
40/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Recently, a number of APP and APP-related proteins have been identified in different organisms and constitute the family of APP proteins. +3 more findings
Full summary, score breakdown and related studies → Original source
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1993-12-01
Expression of APP in brains of transgenic mice containing the entire human APP gene
37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Biochemical and biophysical research communications
Key finding: Recent evidence indicates that increases in APP expression and/or beta/A4 peptide accumulation may underlie the amyloidosis characteristic of these diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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1993-12-01
Factors determining the decision to institutionalize dementing individuals: a prospective study
52/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: This longitudinal study of 196 caregiver/care receiver dyads was undertaken to determine the variables predictive of caregiver decision to institutionalize a dependent with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
November 1993 5
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1993-11-01
The course of geriatric depression with "reversible dementia": a controlled study
59/100 ✓ Peer-reviewed Risk factors American Journal of Psychiatry
Key finding: Irreversible dementia developed significantly more frequently in the depressed group with reversible dementia (43%) than in the group with depression alone (12%). +4 more findings
Full summary, score breakdown and related studies → Original source
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1993-11-01
Does sleep disturbance predict depression in elderly people? A study in inner London
64/100 ✓ Peer-reviewed Risk factors Europe PMC (PubMed Central)
Key finding: Sleep disturbance was associated with being a woman, being unmarried, living alone, disability, and current and future depression, but not with dementia or older age. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-11-01
The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology
Key finding: We found far fewer SP in normal control subjects than in AD patients, who in turn have fewer SP than elderly DS patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-11-01
Clock completion: an objective screening test for dementia
36/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: A simple, completely objective scoring system for a clock completion test has been developed which involves only the number of digits placed in the fourth quadrant of a pre-drawn circle. +1 more finding
Full summary, score breakdown and related studies → Original source
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1993-11-01
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease
36/100 ✓ Peer-reviewed Vascular contributions Proceedings of the National Academy of Sciences of the United States of America
Key finding: Reinvestigation of the chemical structure of beta-amyloid peptide (A beta) deposits in the vascular tissue of Alzheimer disease brains revealed that the 42-residue form A beta-(1-42), rather than the more soluble A beta-(1-40) form, is the predominant peptide. +2 more findings
Full summary, score breakdown and related studies → Original source
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