alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26889 of the 27780 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,476–25,500 of 27,780 studies, newest first · page 1020 of 1112.

August 2001 18

  1. 2001-08-21

    Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

    Key finding: We found that transgenic expression of human APP in B6SJL mice, under the prion promoter, results in immune hyporesponsiveness to human Abeta, in terms of both antibody and cellular immune responses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2001-08-01

    Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

    ✓ Peer-reviewed Biomarkers The European journal of neuroscience

    Key finding: Quantification of thioflavine-S-positive Abeta deposits revealed a marked acceleration of amyloid deposition in LPS-treated APPV717F+/+-apoE+/+ mice compared to nontreated or vehicle-treated APPV717F+/+-apoE+/+ mice (P = 0.005). +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2001-08-01

    Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro

    ✓ Peer-reviewed Biomarkers Journal of virology

    Key finding: Compared with wild-type controls, CNS expression of the CC chemokine gene CCL2/MCP-1 and the CXC chemokine genes CXCL10/IP-10 and CXCL9/Mig was induced in the GFAP-HIV gp120 mice. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2001-08-01

    Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

    ✓ Peer-reviewed Biomarkers Experimental neurology

    Key finding: Behavioral phenotypes of apoE3 and apoE4 TG mice were derived by conducting a longitudinal study in which apoE3 and apoE4 TG mice were compared with apoE KO and wild-type (WT) mice (all male) on several behavioral measures. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2001-08 month only

    Homocysteine, vascular dementia and Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Clinical chemistry and laboratory medicine

    Key finding: There are only a few intervention studies, and the results are disappointing for such a frequent disease.

    Full summary, score breakdown and related studies → Original source

  6. 2001-08-01

    Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry

    Key finding: To address this question we first studied DSCR1 (Adapt78) in multiple human tissues and found significant expression in brain, spinal cord, kidney, liver, mammary gland, skeletal muscle, and heart. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2001-08-01

    Cerebral microvascular pathology in aging and Alzheimer's disease

    ✓ Peer-reviewed Vascular contributions Progress in neurobiology

    Key finding: The aging of the central nervous system and the development of incapacitating neurological diseases like Alzheimer's disease (AD) are generally associated with a wide range of histological and pathophysiological changes eventually leading to a compromised cognitive status.

    Full summary, score breakdown and related studies → Original source

  8. 2001-08-01

    Nicastrin binds to membrane-tethered Notch

    ✓ Peer-reviewed Drug development Nature cell biology

    Key finding: In addition, we report that the Notch and betaAPP pathways do not significantly compete with each other.

    Full summary, score breakdown and related studies → Original source

  9. 2001-08-01

    A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD

    ✓ Peer-reviewed Genetics Neurology

    Key finding: As the first 1-year, multinational, double-blinded, placebo-controlled study of a cholinesterase inhibitor in AD, these data support donepezil as a well tolerated and effective long-term treatment for patients with AD, with benefits over placebo on global assessment, cognition, and ADL. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2001-08-01

    The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians

    ✓ Peer-reviewed Hippocampus size on brain scans Primary care companion to the Journal of clinical psychiatry

    Key finding: The data support that HPA axis activation is common in depressed patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2001-08-01

    Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder.

    Full summary, score breakdown and related studies → Original source

  12. 2001-08-01

    Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

    ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

    Key finding: Although QUIN has been shown to be produced in neurotoxic concentrations by macrophages and microglia, the role of astrocytes in QUIN production is controversial. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2001-08-01

    In-vivo measurement of activated microglia in dementia

    ✓ Peer-reviewed Inflammation and the immune system Lancet (London, England)

    Key finding: The transition of microglia from the normal resting state to the activated state is associated with an increased expression of receptors known as peripheral benzodiazepine binding sites, which are abundant on cells of mononuclear phagocyte lineage. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2001-08-01

    Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: We examined whether cholesterol might be present in senile plaques, a hallmark neuropathological feature of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2001-08-01

    Functional genomics of the Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Croatian medical journal

    Key finding: Down syndrome, as a phenotypic result of trisomy 21, is a complex condition with a set of over 30 phenotypic features, which manifest themselves with varying frequencies among affected individuals. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2001-08-01

    A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Patients' mean age was 73.6 years (range 48 to 92 years). +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2001-08-01

    A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Patients with AD continue to show detectable disease progression over time, but treatment with donepezil for 1 year was associated with a 38% reduction in the risk of functional decline compared with placebo. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2001-08-01

    Oxidative damage is the earliest event in Alzheimer disease

    ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology

    Key finding: Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). +4 more findings

    Full summary, score breakdown and related studies → Original source

July 2001 7

  1. 2001-07-15

    The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

    ✓ Peer-reviewed Disease mechanisms Journal of Neurochemistry

    Key finding: Western blots of immunoprecipitated HNE-immunoreactive proteins from the inferior parietal lobule of AD and control brains suggest that HNE is conjugated to GLT-1 to a greater extent in the AD brain. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2001-07-01

    The Association Between Caregiver Burden and Caregiver Health-Related Quality of Life in Alzheimer Disease

    ✓ Peer-reviewed Costs and economics Alzheimer Disease & Associated Disorders

    Key finding: The burden experienced by family caregivers of individuals with Alzheimer disease (AD) affects the caregivers' overall health-related quality of life (HRQOL).

    Full summary, score breakdown and related studies → Original source

  3. 2001-07-01

    Accuracy of administrative data to assess comorbidity in patients with heart disease. an Australian perspective

    ✓ Peer-reviewed Digital health tools Journal of clinical epidemiology

    Key finding: These were compared with the 10 discharge codes obtained from the hospital administrative records (referred to as the "administrative data").

    Full summary, score breakdown and related studies → Original source

  4. 2001-07-01

    Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images

    ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)

    Key finding: Progressive atrophy was revealed in presymptomatic individuals, with posterior cingulate and neocortical temporoparietal cortical losses, and medial temporal-lobe atrophy.

    Full summary, score breakdown and related studies → Original source

  5. 2001-07-01

    Informal costs of dementia care: estimates from the National Longitudinal Caregiver Study

    ✓ Peer-reviewed Costs and economics The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: This study provides a comprehensive estimate of the excess costs that result from providing informal dementia care in the community. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2001-07-01

    Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians

    ✓ Peer-reviewed Biomarkers Journal of the American Geriatrics Society

    Key finding: Because they have a high prevalence of several common diseases and chronic conditions, Danish centenarians are not healthy.

    Full summary, score breakdown and related studies → Original source

  7. 2001-07-01

    The ABILHAND questionnaire as a measure of manual ability in chronic stroke patients: Rasch-based validation and relationship to upper limb impairment

    ✓ Peer-reviewed Vascular contributions Stroke

    Key finding: The ABILHAND questionnaire results in a valid person-centered measure of manual ability in everyday activities. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →