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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Cognitive tests and assessment

Topic: Amyloid, tau and blood-test diagnosis

The clinical impact of Alzheimer's disease pathology at biopsy was investigated in 56 cognitively impaired patients undergoing shunt surgery for idiopathic normal pressure hydrocephalus (NPH). Cognition was measured by means of the global deterioration scale (GDS), the mini mental status examination (MMSE) and a battery of six psychometric tests. Gait was assessed using objective measurements of velocity and the ambulatory index (AI).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Golomb, J., Wisoff, J., Miller, D. C., Boksay, I., Kluger, A., Weiner, H., et al. (2000). Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.68.6.778

Vancouver

Golomb J, Wisoff J, Miller DC, Boksay I, Kluger A, Weiner H, et al. Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response. Journal of neurology, neurosurgery, and psychiatry. 2000. doi:10.1136/jnnp.68.6.778. PMID: 10811706.

BibTeX

@article{golomb2000-10811706,
  author  = {Golomb, J. and Wisoff, J. and Miller, D. C. and Boksay, I. and Kluger, A. and Weiner, H. and Salton, J. and Graves, W.},
  title   = {{Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2000},
  doi     = {10.1136/jnnp.68.6.778},
  pmid    = {10811706},
  url     = {https://doi.org/10.1136/jnnp.68.6.778}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Cognition was measured by means of the global deterioration scale (GDS), the mini mental status examination (MMSE) and a battery of six psychometric tests.
Gait was assessed using objective measurements of velocity and the ambulatory index (AI).
The prevalence of cases exhibiting neuritic plaques (positive biopsies) increased in parallel with dementia severity from 18% for patients with GDS 3 to 75% for patients with GDS scores > or =6.
Patients with positive biopsies were more cognitively impaired (higher GDS and lower MMSE scores) as well as more gait impaired (higher AI scores and slower velocities) than patients with negative biopsies.

Why it matters

This study investigated the prevalence of Alzheimer's disease pathology at biopsy and shunt response in patients with idiopathic normal pressure hydrocephalus. It concerns surgical outcomes in a specific patient group and does not test treating, curing or preventing Alzheimer's disease itself.

Study details

Evidence strengthLow

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry)
Journal's citation record	3 / 4	Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2000 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 282 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.1 citations a year over 28 year(s) since 2000
Impact for its field and year	2 / 6	Cited 1.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 6 other studies in this library
Still being cited	2 / 4	Cited 30 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author James B. Golomb: h-index 26 (OpenAlex, whole career)
Institution's track record	2 / 3	New York University: institution h-index 1,612 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 10811706)
Free to read	0 / 2	Behind a paywall — scores zero
Total	42 / 100	—

What each of these 20 components measures, and what this score is not →

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