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Inflammation and Alzheimer's disease
Haruhiko Akiyama. Neurobiology of Aging, 2000-06-01
Topic: Amyloid, tau and blood-test diagnosis
This text examines how inflammation occurs in vulnerable regions of the Alzheimer's disease brain in response to stimuli like damaged neurons and insoluble deposits. It explains that this chronic local inflammatory response likely exacerbates underlying pathogenic processes over many years. Consequently, studies suggest that inflammation contributes to the pathogenesis of the disorder, offering a basis for potential anti-inflammatory approaches to slow its progression or delay its onset.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Akiyama, H. (2000). Inflammation and Alzheimer's disease. Neurobiology of Aging. https://doi.org/10.1016/s0197-4580(00)00124-x
Vancouver
Akiyama H. Inflammation and Alzheimer's disease. Neurobiology of Aging. 2000. doi:10.1016/s0197-4580(00)00124-x. PMID: 10858586.
BibTeX
@article{akiyama2000-10858586,
author = {Akiyama, Haruhiko},
title = {{Inflammation and Alzheimer's disease}},
journal = {Neurobiology of Aging},
year = {2000},
doi = {10.1016/s0197-4580(00)00124-x},
pmid = {10858586},
url = {https://doi.org/10.1016/s0197-4580(00)00124-x}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease (AD) brain, and it does so with the full complexity of local peripheral inflammatory responses.
- Cumulated over many years, direct and bystander damage from AD inflammatory mechanisms is likely to significantly exacerbate the very pathogenic processes that gave rise to it.
- Thus, animal models and clinical studies, although still in their infancy, strongly suggest that AD inflammation significantly contributes to AD pathogenesis.
Why it matters
Addresses inflammation and its place in Alzheimer's disease. Inflammation is presented as a feature of the disease to investigate rather than as something treated here.
Study details
- Evidence strengthLow
How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 57 of the 97 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of Aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2000 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 4,521 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 161.5 citations a year over 28 year(s) since 2000 |
| Impact for its field and year | 6 / 6 | Cited 76.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 155 other studies in this library |
| Still being cited | 4 / 4 | Cited 397 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Haruhiko Akiyama: h-index 101 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10858586) |
| Free to read | 2 / 2 | Free to read |
| Points | 57 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 57 of the 97 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s0197-4580(00)00124-x
- PubMed: 10858586
- Original source →
- Free full text: Amsterdam UMC (VU Amsterdam) - Institutional Repository →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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