Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Flooding has become more frequent and severe worldwide, leading to an increased burden of psychiatric disorders (e.g., depression and anxiety).
Why it matters
In this UK Biobank cohort, flood exposure was linked to an 8.0% higher risk of dementia, and this link was partly mediated by psychiatric disorders, especially psychotic disorder. The findings describe an environmental association and mediation pattern, not a treatment or prevention approach.
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The tests qualitatively and statistically associated to a cognitive decline are MMSE, FAB, BSTR, AM, and VSF, of which at least three were considered the most informative also by machine learning. 73% average accuracy was obtained in the diagnosis prediction on three subsets of original and external data.
Why it matters
This study found that certain neuropsychological tests were associated with cognitive decline and that machine learning models predicted diagnosis with 73% average accuracy. It is about identifying informative tests and predicting progression, not about treating, curing or preventing Alzheimer's disease.
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40/100
This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating cognitive decline.
Why it matters
In this 12-week study of 154 older adults with cognitive decline, aerobic and strength training improved physical performance measures but produced no significant improvement in cognitive function. It found no cognitive benefit from the exercise programs tested.
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Age-related macular degeneration (AMD) is a multifactorial disorder influenced by genetic, lifestyle, nutritional, and systemic health factors that contribute to increased oxidative stress and chronic inflammation in the retina.
Why it matters
This review is about modifiable lifestyle risk factors for age-related macular degeneration, an eye disease, and does not address Alzheimer's disease. It reports that smoking, physical inactivity, prolonged sunlight exposure and certain health conditions are linked to higher AMD risk, and that specific vitamin and mineral combinations and a Mediterranean diet may reduce progression.
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Conducting high-quality health technology assessments requires high-quality evidence.
Why it matters
This review discusses how health technology assessors handle limited evidence, using Alzheimer's disease therapies as one example. It offers policy solutions such as reimbursement with evidence development and outcomes-based contracts, but does not test any treatment, cure, or prevention.
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40/100
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with considerable variability of age-at-onset.
Why it matters
This retrospective study found clinical and metabolic differences between early- and late-onset behavioral frontotemporal dementia, with greater verbal memory deficit in late-onset groups. It describes different disease phenotypes rather than testing any treatment or prevention.
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In the last 5 years significant progress has been made in potential dementia treatments, yet many of these treatments come with significant burdens on the healthcare system that may limit access to treatment and care for patients.
Why it matters
This viewpoint discusses barriers to equitable access to dementia treatments and clinical trials, noting that patients in remote, rural, and low-income regions are disadvantaged and that trials often recruit homogeneous groups. It offers a potential framework involving infrastructure, regulatory change, and patient education, but reports no treatment, cure, or prevention results.
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This study examined relationships among caregiver burden, depressive symptoms, and key processes related to psychological flexibility (experiential avoidance, cognitive fusion, values-driven actions, and mindfulness) in 157 family caregivers of individuals with dementia in the United States.
Why it matters
This path analysis of 157 family caregivers found that caregiver burden had both a direct effect on depressive symptoms and indirect effects through psychological flexibility processes such as values-driven action, cognitive fusion, and experiential avoidance. It suggests that acceptance and commitment therapy may help reduce the impact of burden on depressive symptoms, but this was not tested.
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Dementia, is a critical global public health challenge with no effective pharmacological treatments.
Why it matters
This review reports that physical activity and dietary habits may mitigate cognitive decline in the elderly and prevent progression to dementia in people with mild cognitive impairment, with different approaches in Western and Asian countries. It supports lifestyle-based risk reduction but presents no cure for Alzheimer's disease.
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Over the past decade, Latin America and the Caribbean (LAC) have made progress in implementing the Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR).
Why it matters
This article is about disaster risk reduction in Latin America and the Caribbean and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and Alzheimer's disease.
Why it matters
Using a type of MRI called free-water diffusion tensor imaging, this study found distinct white matter changes in people with late MCI compared with early MCI, even though MMSE scores did not differ between the two groups. These findings suggest specific white matter tracts are involved in MCI progression and may help with early diagnosis, but the study does not test any treatment.
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This paper presents the results of a long-term exploratory study that examined the social and emotional impact of using a social robot with a variety of applications to promote activities for people with advanced dementia and their caregivers.
Why it matters
In this 10-month exploratory study, a social robot was used with 13 people with advanced dementia, their family members, and professional caregivers in a secured care environment. Findings suggest potential to improve well-being, engagement, and social interaction, but the authors present this as early work needing future research.
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The study cohort included 7167 delirium cases and 7167 matched controls.
Why it matters
This study developed electronic health record-based models to predict postoperative delirium in surgical patients without dementia, with the best model achieving good predictive ability on internal data. However, performance decreased when validated on data from other hospitals, indicating limited generalisability.
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In 2020, the Centers for Medicare and Medicaid Services reintroduced Alzheimer's disease and related dementias to its risk-adjustment payment model for Medicare Advantage (MA) plans.
Why it matters
This study found that reintroducing dementia to Medicare Advantage risk adjustment was associated with an 11.5 percent increase in incident dementia diagnoses relative to traditional Medicare. It does not test any treatment, cure, or prevention for Alzheimer's disease, and it raises questions about potential overdiagnosis or upcoding.
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CompBased-CAT demonstrated good test–retest reliability, with an ICC of 0.64 among all participants, which increased to 0.74 among participants with MCI over a 2-month period, indicating its potential for monitoring cognitive function through repeated assessments.
Why it matters
This study found that a computer-based cognitive assessment tool had good test-retest reliability over about two months in community-dwelling older Japanese adults, with an ICC of 0.64 overall and 0.74 among participants with MCI. It is about a monitoring tool and does not treat, cure or prevent Alzheimer's disease.
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Kolb’s experiential learning theory has a positive impact on alleviating the caregiving burden and reducing anxiety and depression among family caregivers of dementia patients.
Why it matters
This study of 110 caregivers found that nursing based on Kolb's experiential learning theory significantly lowered caregiver burden scores and reduced anxiety and depression compared with routine care. The findings concern caregiver support and do not address treating, curing, or preventing Alzheimer's disease.
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Higher education was associated with higher initial cognitive status but faster decline.
Why it matters
Over up to 8 years, this study found that higher education was linked to better initial thinking skills but faster decline, while antidiabetic medication was linked to slower decline and depression or vision problems to faster decline. Treating conditions like diabetes and vision impairment may help slow dementia symptoms, supporting the idea that modifiable factors can affect disease progression.
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= 1,217; 65.0 years) showed earlier initial MMSE scores (by 6.1 years, 95% CI = 5.2-7.0), earlier dementia diagnoses (by 2.3 years, 95% CI = 0.9-3.7) but lower dementia risk (adjusted HR = 0.81; 95% CI = 0.69-0.95).
Why it matters
In this study of 1,217 patients, those with schizophrenia spectrum disorders had earlier initial MMSE scores and earlier dementia diagnoses but lower dementia risk than those with affective disorders. They also took longer to receive a dementia diagnosis and were less likely to be prescribed anti-dementia medication.
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Our findings indicate that the severity of cognitive impairment was significantly associated with an increased risk of falls in patients with dementia.
Why it matters
In this study of 30 dementia patients, the severity of cognitive impairment was significantly associated with increased risk of falls. The authors recommend fall risk screening for these patients.
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EOD participants reported the highest mean levels of all psychosocial outcomes (e.g., everyday discrimination score of 8.3 in EOD vs 4.6 in LOD and 6.8 in no-dementia).
Why it matters
People with early-onset dementia reported more everyday discrimination, discrimination in healthcare settings and perceived stress than those with late-onset dementia, but no difference in loneliness was found between the two groups. The authors call for targeted support for younger people with dementia and their families.
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The manuscript provides a thorough analysis of the neurovascular and metabolic processes that contribute to cognitive deterioration in patients with Type 2 diabetes (T2D).
Why it matters
This review discusses how type 2 diabetes-related metabolic and blood vessel problems may contribute to cognitive decline and suggests possible biomarkers for early detection. It is a review and does not provide evidence that any treatment cures or prevents Alzheimer's disease.
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Oropharyngeal dysphagia (OD) is a highly prevalent geriatric syndrome that remains underdiagnosed and undertreated, often resulting in severe nutritional and respiratory complications with poor clinical outcomes.
Why it matters
This narrative review found oropharyngeal dysphagia significantly associated with eight groups of risk factors in older patients, including dementia among several phenotypes. It describes risk factors and complications rather than testing any treatment, cure, or prevention for Alzheimer's disease.
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40/100
This Medical News article discusses care denials under Medicare Advantage plans and efforts to streamline the prior authorization process.
Why it matters
This news article discusses care denials under Medicare Advantage plans and efforts to streamline the prior authorization process. It contains no research findings on treating, curing, or preventing Alzheimer's disease.
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Little is known about the extent of prior authorization requirements in otolaryngology.
Why it matters
This analysis found that prior authorization requirements for otolaryngologic procedures varied widely among Medicare Advantage insurers, with nearly half of affected services subject to prior authorization by a single insurer. It contains no research findings on treating, curing, or preventing Alzheimer's disease.
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Dementia specialists-neurologists, geriatricians, and geriatric psychiatrists-serve a critical clinical function in diagnosing early-stage Alzheimer's disease and determining eligibility for treatment with disease-modifying therapies.
Why it matters
This study estimated that 34% to 59% of Americans aged 65 and older live in areas with potential shortfalls of dementia specialists, who diagnose early-stage Alzheimer's disease and determine eligibility for disease-modifying therapies. It does not test a treatment or prevention, so it cannot show how to cure or prevent dementia.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cognitive processes related to gait velocity: results from the Einstein Aging Study
- Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown
- Frontotemporal dementia characterization using neurite orientation dispersion and density imaging
- A review of multidomain interventions to support healthy cognitive ageing
- The older adult driver with cognitive impairment: "It's a very frustrating life"
- Three methods of assessing values for advance care planning: comparing persons with and without dementia
- Vascular Cognitive Impairment
- Processes of decision making and end-of-life care for patients with dementia in group homes in Japan
- Neurological complications in renal failure: a review
- Ageing and infection