Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The positive effects might be caused by the systematic and tailored individual way of information provisioning by DEM-DISC.
Why it matters
In a pilot study, 14 informal carers who could access the DEM-DISC system at home for two months reported more met and less unmet needs, and carers in the experimental group reported higher levels of competence than controls, though they were not explicitly satisfied with the first prototype. This is a small pilot study of an information tool and does not test treating, curing or preventing Alzheimer's disease.
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This paper reviews the characteristics of sleep disorders found in people at a greater risk of dementia: the elderly adult, patients with mild cognitive impairment (MCI) and those with neurodegenerative diseases.
Why it matters
This review describes sleep disorders in older adults, people with mild cognitive impairment, and people with neurodegenerative diseases, noting that poor sleep increases the risk of health problems and caregiver stress. It does not report any treatment, cure, or prevention of Alzheimer's disease.
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Those who reached the DBT in both years had higher morbidity and utilization.
Why it matters
This study found that Medicare beneficiaries who repeatedly reached the drug benefit threshold were more likely to have conditions including dementia and to use trade-name medications with limited generic alternatives. It addresses medication costs in dementia but does not test any treatment, cure, or prevention for Alzheimer's disease.
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The relationship between diet and cognitive function has been a topic of increasing interest, as numerous studies have shown that variations in dietary practices and nutrient intake may protect against age-related cognitive decline, as well as the development of dementia and Alzheimer's Disease (AD).
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Age is the largest risk factor for the development and progression of Parkinson's disease (PD).
Why it matters
This review states that age is the largest risk factor for Parkinson's disease and that ageing may increase the risk of developing dementia in Parkinson's disease. It describes how ageing affects disease presentation but does not test any treatment, cure, or prevention for Alzheimer's disease.
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The prevalence of dementia is expected to increase dramatically over the upcoming decades due to the aging population.
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Older adults who report more severe acute or chronic pain have smaller hippocampal volumes and lower levels of hippocampal N-acetylaspartate/creatine, a marker of neuronal integrity.
Why it matters
In this small pilot study of 20 nondemented older adults, smaller hippocampal volume was associated with higher bodily pain ratings and lower hippocampal NAA/Cr was associated with higher acute pain severity. This concerns pain and the hippocampus in healthy elderly adults, not treating, curing or preventing Alzheimer's disease.
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Mild AD significantly impaired simulated driving fitness, while MCI limitedly affected driving performance.
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Qualitative methodology based on action research identified challenges when caring for persons with advanced dementia, as perceived by key professional providers.
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Hispanic subjects were, on average, significantly younger and had less years of education than African Americans or whites.
Why it matters
Clinical dementia diagnoses were associated with consistent differences in brain structure on MRI across African American, white, and Hispanic participants. This helps validate diagnostic assessment across diverse groups but does not treat, cure, or prevent dementia.
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The findings suggest that specific cultural attitudes towards the caregiving role have important implications for how carers can best be supported.
Why it matters
This qualitative study found that Black Caribbean, south Asian, and White British carers held traditional or non-traditional caregiver ideologies that shaped their feelings of fulfilment, strain, fears, and attitudes toward formal services. It suggests cultural attitudes matter for how carers can best be supported, not for treating or preventing dementia.
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All antipsychotics are associated with an increased risk of stroke, and the risk might be higher in patients receiving atypical antipsychotics than those receiving typical antipsychotics.
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The Cache County Study of Memory in Aging (CCMS) is an epidemiological study of Alzheimer's disease (AD), mild cognitive disorders, and aging in a population of exceptionally long-lived individuals (7th to 11th decade).
Why it matters
In older people without dementia, advanced age and low education were linked to lower test scores across nearly all neurocognitive measures, while APOE epsilon4 had negligible and inconsistent effects once age and education were controlled. This provides information about normal cognition in advanced age rather than a treatment, cure or prevention for Alzheimer's disease.
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The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable with IBASPM.
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43/100
Patients who survive to the final phase of dementia are more likely to die from cachexia or dehydration than those who die before.
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In aged and pathological populations, reduced hippocampal volume is frequently described in association with impairment of hippocampus-dependent cognitive processes and chronically elevated cortisol levels.
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Smaller hippocampal volume is associated with psychiatric disorders.
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Corticobasal degeneration (CBD) has characteristic neuropathological features, but is a clinically heterogeneous disorder.
Why it matters
This review describes the clinical heterogeneity of corticobasal degeneration, noting that the corticobasal syndrome is not specific for its pathology and that patients with this syndrome could potentially be candidates for therapies aiming to modify tau biochemistry. It does not itself test any treatment, cure or prevention.
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When assessed via instrumentation, swallowing abnormalities are found in many patients with FTLD.
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Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested with a virtual Morris water task.
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43/100
Hippocampal sclerosis (HS) is characterized by selective neuronal loss and gliosis in CA1 and the subiculum and has been associated with several disorders, including Alzheimer's disease, frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions (FTLD-U), vascular dementia and some tauopathies.
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43/100
The NUCOG was undertaken with the MMSE on a total of 347 individuals, with 82 subjects in the control group and 265 in the patient group.
Why it matters
This study examined the validity and reliability of a brief cognitive screen, the NUCOG, in 347 people including patients with dementia, psychiatric illness and neurological disorders, and compared it with the MMSE. It is about a screening tool, not a treatment or cure.
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Alzheimer's disease (AD) and diabetes mellitus (DM) are two of the most common and devastating health problems in the elderly.
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Better communication, greater resident comfort, no tube feeding, and care in a specialized dementia unit are modifiable factors that may improve satisfaction with care in advanced dementia.
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Structural and functional magnetic resonance imaging (fMRI) was performed on 21 healthy elderly controls, 14 subjects with mild cognitive impairment (MCI) and 15 patients with mild Alzheimer's disease (AD) to investigate changes in fMRI activation in relation to underlying structural atrophy.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- A group intervention to improve quality of life for people with advanced dementia living in care homes: the Namaste feasibility cluster RCT
- Barriers to excellent end-of-life care for patients with dementia
- Long-term metformin usage and cognitive function among older adults with diabetes
- Exploring Neighborhood-Level Environmental Justice to Tackle County-Level Disparities in Breast Cancer Outcomes
- Prevalence and impact of caregiving: a detailed comparison between dementia and nondementia caregivers
- Relationship of Early-Life Residence and Educational Experience to Level and Change in Cognitive Functioning: Results of the Minority Aging Research Study
- Nonalcoholic fatty liver disease and aging: epidemiology to management
- Multicomponent Exercise and Functional Fitness: Strategies for Fall Prevention in Aging Women
- Marriage and risk of dementia: systematic review and meta-analysis of observational studies
- Hearing Loss, Hearing Aid Use, and Risk of Dementia in Older Adults