Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Mild cognitive impairment (MCI) is the transitional stage between normal cognition and dementia and is associated with arterial stiffness, which may lead to cardiovascular disease.
Why it matters
This randomized trial found that water-based exercise alone and combined with cognitive training improved cognitive performance and cardiovascular fitness in older adults with mild cognitive impairment. It suggests possible benefits for these outcomes, but it does not show that the exercise treats, cures or prevents Alzheimer's disease.
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33/100
Three hundred fourteen articles from 48 countries were included.
Why it matters
This bibliometric analysis of nutrition in palliative care at the end of life found annual publications remain limited with low collaboration. Trend topics shifted toward refusal of nutrition, ethics, family, and bereavement, away from prior themes such as withdrawal of life-sustaining therapy in advanced cancer or dementia.
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This study explores how older people with dementia and their family caregivers experience the process from diagnosis to follow-up in primary care, what support is needed, what works well and what could be improved.
Why it matters
In interviews with four people with dementia and 11 family caregivers in Sweden, four themes described gaps in communication and follow-up between memory clinics and primary care that left people feeling abandoned. The authors call for sustainable, person-centered dementia care models in primary care, but no treatment, cure or prevention was tested.
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Various negative and positive aspects, along with specific needs, were identified.
Why it matters
Interviews with formal caregivers in Chinese nursing homes found they face multiple pressures and challenges in end-of-life care for people with advanced dementia. It does not test any treatment, cure or prevention.
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This real-life study aims to describe and compare the characteristics of patients who do or do not receive speech therapy after a memory consultation.
Why it matters
This real-life study found that a diagnosis of Alzheimer's disease was the characteristic most strongly associated with receiving speech therapy after a memory consultation, while female gender, lower education, and lower cognitive efficiency were associated with lower probability of speech therapy. It describes access to speech therapy, not treating, curing, or preventing Alzheimer's disease.
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MA-PD enrollees had significantly lower utilization of PIMs than standalone PDP enrollees: a 0.7 percentage-point [95% CI: 0.5, 0.8] lower prevalence of potentially harmful drug-disease interactions in older adults with dementia; a 3.1 percentage-point [2.6, 3.5] lower prevalence of potentially harmful drug-disease interactions in older adults with dementia and a history of falls; and a 0.5 percentage-point [0.4, 0.6] lower prevalence of high-risk medications in older adults.
Why it matters
This study compared use of potentially inappropriate medications between Medicare Advantage and standalone prescription drug plan enrollees with dementia. It found Medicare Advantage enrollees had lower use of these medications, which is about safer prescribing rather than treating, curing or preventing Alzheimer's disease.
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This study aimed to investigate the association between delirium and incident dementia in elderly (≥65 years) type 2 diabetes mellitus (T2DM) patients, addressing the heightened dementia risk in this population. newly diagnosed between January 1, 2005, and December 31, 2007.
Why it matters
This study found a strong association between delirium and increased risk of dementia in elderly type 2 diabetes patients, with a dose-response pattern where each additional delirium episode amplified dementia risk. The authors suggest a potential causal link and advocate for targeted interventions, but the study design cannot prove causation.
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Mild cognitive impairment (MCI) is primarily characterized by a gradual decline in cognitive function, where early detection and intervention are crucial to preventing Alzheimer's disease progression.
Why it matters
In 37 elderly participants, combining upper limb multimodal tasks with functional near-infrared spectroscopy showed weaker cortical responses in the mild cognitive impairment group during rest and reduced motor cortex activation during a numerical cognitive task. This is a small assessment study exploring early detection, not a treatment or cure.
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Three hundred adult patients were included in the study.
Why it matters
This cluster analysis of 300 palliative care patients found three main trajectories in the last three months of life, with dementia and having children limiting hospitalization. Not having an informal caregiver and having dementia were associated with staying in a nursing home.
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A balanced understanding of dementia’s impact (acknowledging both continuity and loss, alternatives and socially constructed aspects) better reflects the realities of dementia and creates new possibilities for supportive care practices to improve pain management and quality of life.
Why it matters
This paper proposes a balanced model of 'total pain' in dementia care that considers both painful and functional experience within a critical context. It is a conceptual discussion of pain management and quality of life, not a treatment or cure for Alzheimer's disease.
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These inputs and activities were shown in the logic model to result in short, medium, and long-term outcomes, including reduced healthcare resource use and increased quality of life for people with dementia at the end of life.
Why it matters
This abstract describes co-designing a model of palliative care for people with advanced dementia, with a logic model linking inputs and activities to outcomes such as reduced healthcare resource use and increased quality of life. In a survey, 83% were satisfied with the model of care and 39% of stakeholders said their awareness of dementia and palliative care services increased.
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Between April 2020 and March 2021, the number of fall-related emergency admissions in England for adults over 65 years was 1933 per 100 000 people.
Why it matters
This quality improvement project in older adults' mental health wards in Wales increased assessments such as lying and standing blood pressure, medication review and delirium assessments, but reported falls rates stayed the same for the five wards. It is about fall prevention in hospital, not about treating, curing or preventing Alzheimer's disease.
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This study aims to investigate how cognitive impairment and social presence influence goal attainment in an ecological virtual environment.
Why it matters
This study used a virtual supermarket task and found that people with mild cognitive impairment made more wandering and orientation errors than cognitively healthy older adults, and that verbal support did not fully remove these deficits. It suggests virtual environments may be useful for assessment and cognitive training, but it does not test a treatment, cure or prevention for Alzheimer's disease.
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Based on the stakeholder responses from fifteen providers and twenty community members, there was strong consensus in the need for local brain health services.
Why it matters
A community brain health initiative in Richmond found strong consensus on the need for local services, with hypertension, depression or anxiety, and loneliness as the most common risk factors among 45 participants. This describes a model for improving access to dementia resources and services, not a treatment, cure, or prevention.
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The prevalence of dysphagia in Aotearoa New Zealand is estimated to have been approximately 1.78% in 2020, with the biggest aetiological contributors being stroke, Alzheimer's disease and other dementias, and gastroesophageal reflux disease.
Why it matters
This study estimates how common dysphagia is in Aotearoa New Zealand and projects it will rise with an ageing population, with Alzheimer's disease and other dementias among the biggest contributing causes. It is about measuring and planning for swallowing problems, not about treating, curing or preventing Alzheimer's disease.
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Mild Cognitive Impairment (MCI) is marked by a measurable decline in cognitive function that exceeds typical age-related changes but does not yet qualify as dementia.
Why it matters
This review synthesizes findings from resting-state fMRI studies showing altered connectivity in the default mode network in people with MCI. The authors suggest these early neural changes may serve as biomarkers for early detection and could inform interventions aimed at delaying progression to dementia, but no treatment was tested.
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We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials.
Why it matters
This commentary argues that lifestyle intervention trials should meet the same rigor as drug trials and points to opportunities to improve rigor in design, data analysis and publication of results. It does not report any new treatment or prevention findings.
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The Cronbach alpha coefficient of the RUDAS scale is 0.8529.
Why it matters
This study found the Turkish version of the RUDAS scale to be valid and reliable for evaluating Alzheimer's disease and mild cognitive impairment. It is a test-validation study and does not address treatment, cure or prevention.
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• Brain health depends on certain environmental resources of which socioeconomically disadvantaged people in particular are deprived. • Resource deprivation may increase dementia risk due to reduced attainment for deprived populations. • Improving attainment across the lifetime for disadvantaged individuals should be a public health priority for dementia prevention.
Why it matters
This review hypothesizes that deprivation of environmental resources increases dementia risk, with reduced educational and professional attainment as a major mediator. It argues for structural interventions to improve attainment and reduce dementia disparities, but does not test a specific treatment or cure.
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The approval of disease-modifying treatments for Alzheimer's disease demands a rethinking of cognitive screening.
Why it matters
Based on over 180 stakeholder interviews, this perspective describes barriers to current cognitive screening and proposes AI and digital biomarkers, especially speech analysis, as scalable screening tools. It is about improving screening and implementation, not about treating, curing, or preventing Alzheimer's disease.
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The moral authority of advance directives (ADs) in the context of persons living with dementia (PLWD) has sparked a multifaceted debate, encompassing concerns such as authenticity and the appropriate involvement of caregivers.
Why it matters
This is a philosophical analysis arguing that advance directives should take precedence over current experiential interests when a person with dementia develops delirium. It does not report any clinical trial or treatment outcome for Alzheimer's disease.
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Financial incentives to detect dementia resulted in more dementia diagnoses, particularly among persons at high risk of dementia and of undetected dementia but also raises concerns about diagnostic upcoding and the potential for over‐diagnosis.
Why it matters
This study found that new dementia diagnoses in Medicare Advantage increased after dementia was added to the risk adjustment model for plan payments in 2019. It is about diagnosis coding and payment incentives, not about treating, curing, or preventing Alzheimer's disease.
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We find that even for a matched sample of TM and MA patients with the same PCP, dementiadiagnosis rates are lower in MA relative to TM.
Why it matters
This study found that Medicare Advantage beneficiaries were slightly less likely to receive a new dementia diagnosis than traditional Medicare beneficiaries seen by the same primary care provider. It is about diagnosis rates, not about treating, curing, or preventing Alzheimer's disease.
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An accessible and navigable neighbourhood physical environment is a critical part of dementia-friendly and inclusive communities (DFCs).
Why it matters
This qualitative study interviewed municipal planners and designers about their needs and challenges in implementing dementia-friendly and inclusive planning and design. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Given that Black Americans have been found to have a higher prevalence of sleep disturbances compared to white Americans, our findings could add to inform future health interventions and policy recommendations that can address modifiable sources of poorer brain health in Black men.
Why it matters
In a small survey of 117 Black American men aged 40-70 in urban areas, education, socioeconomic status, and bodily symptoms predicted subjective cognitive decline, which may signal a path toward Alzheimer's disease and related dementias. Because this is a small survey, it cannot show cause and effect or whether any intervention would reduce risk.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Predicting Cognitive Impairment and Dementia: A Machine Learning Approach
- The effects of an immersive virtual reality and telemedicine-based multi-component intervention in individuals with subjective cognitive decline: study protocol of a randomized controlled trial
- Sepsis-Associated Encephalopathy: From Delirium to Dementia?
- Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study
- The impact of cognitive training and physical rehabilitation on activity and quality of life in elderly patients
- Premorbid cognitive leisure independently contributes to cognitive reserve in multiple sclerosis
- Process evaluation of APPLE-Tree (active prevention in people at risk of dementia through lifestyle behaviour change and technology to build resilience): dementia prevention study focused on health and lifestyle changes
- Associations between cognitively stimulating leisure activities, cognitive function and age-related cognitive decline
- Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution
- Lecanemab (Leqembi)