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Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown
Baschi R, Luca A, Nicoletti A, Caccamo M, Cicero CE, D'Agate C, Di Giorgi L, La Bianca G et al.. Frontiers in psychiatry, 2020-12-14
Topic: Risk, prevention and care in population studies
All groups showed a worsening of cognitive (39.6%), pre-existing (37.5%), and new (26%) behavioral symptoms, and motor symptoms (35.4%) during the COVID-19 lockdown, resulting in an increased caregiver burden in 26% of cases. After multivariate analysis, PD-MCI was significantly and positively associated with the IADL lost during quarantine (OR 3.9, CI 1.61-9.58), when compared to PD-NC. In the analysis of MCInoPD vs. PD-MCI, the latter showed a statistically significant worsening of motor symptoms than MCInoPD (OR 7.4, CI 1.09-45.44). Regarding NPI items, nighttime behaviors statistically differed in MCInoPD vs. PD-MCI (16.1% vs. 48.4%, p = 0.007). MDS-UPDRS parts I and II revealed that PD-MCI showed a significantly higher frequency of cognitive impairment ( p = 0.034), fatigue ( p = 0.036), and speech ( p = 0.013) than PD-NC. On the contrary, PD-MCI showed significantly higher frequencies in several MDS-UPDRS items compared to MCInoPD, particularly regarding pain ( p = 0.001), turning in bed (p = 0.006), getting out of bed ( p = 0.001), and walking and balance ( p = 0.003). The COVID-19 quarantine is associated with the worsening of cognitive, behavioral, and motor symptoms in subjects with PD and MCI, particularly in PD-MCI. There is a need to implement specific strategies to contain the effects of quarantine in patients with PD and cognitive impairment and their caregivers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Baschi, R., Luca, A., Nicoletti, A., Caccamo, M., Cicero, C. E., D'Agate, C., et al. (2020). Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2020.590134
Vancouver
Baschi R, Luca A, Nicoletti A, Caccamo M, Cicero CE, D'Agate C, et al. Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown. Frontiers in psychiatry. 2020. doi:10.3389/fpsyt.2020.590134. PMID: 33381057.
BibTeX
@article{baschi2020-33381057,
author = {Baschi, R. and Luca, A. and Nicoletti, A. and Caccamo, M. and Cicero, C. E. and D'Agate, C. and Di Giorgi, L. and La Bianca, G. and others},
title = {{Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown}},
journal = {Frontiers in psychiatry},
year = {2020},
doi = {10.3389/fpsyt.2020.590134},
pmid = {33381057},
url = {https://doi.org/10.3389/fpsyt.2020.590134}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- All groups showed a worsening of cognitive (39.6%), pre-existing (37.5%), and new (26%) behavioral symptoms, and motor symptoms (35.4%) during the COVID-19 lockdown, resulting in an increased caregiver burden in 26% of cases.
- After multivariate analysis, PD-MCI was significantly and positively associated with the IADL lost during quarantine (OR 3.9, CI 1.61-9.58), when compared to PD-NC.
- PD-MCI, the latter showed a statistically significant worsening of motor symptoms than MCInoPD (OR 7.4, CI 1.09-45.44).
- Regarding NPI items, nighttime behaviors statistically differed in MCInoPD vs.
- MDS-UPDRS parts I and II revealed that PD-MCI showed a significantly higher frequency of cognitive impairment ( p = 0.034), fatigue ( p = 0.036), and speech ( p = 0.013) than PD-NC.
Why it matters
This study found that during the COVID-19 lockdown, people with Parkinson's disease and mild cognitive impairment showed worsening cognitive, behavioral, and motor symptoms, with increased caregiver burden. It describes the impact of quarantine on symptoms and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Participants34
- Effect size39.6%; 37.5%; 35.4%
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in psychiatry) |
| Journal's citation record | 2 / 4 | Frontiers in Psychiatry: journal h-index 194 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 34 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 73 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.1 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Roberto Monastero: h-index 42 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Catania: institution h-index 518 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33381057) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fpsyt.2020.590134
- PubMed: 33381057
- Original source →
- Free full text: Frontiers in Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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