Home › Research › Prevention trials
Type 2 Diabetes and Cognitive Decline: A Neurovascular Perspective
Arbind Kumar Choudhary. Chronicle of Diabetes Research and Practice, 2025-01-01
Topic: Risk, prevention and care in population studies
The manuscript provides a thorough analysis of the neurovascular and metabolic processes that contribute to cognitive deterioration in patients with Type 2 diabetes (T2D). The findings highlight the critical roles of hyperglycemia, insulin resistance, and neuroinflammation, along with vascular abnormalities such as endothelial dysfunction and disruptions in the blood–brain barrier, which collectively exacerbate cognitive impairment. Comorbidities such as hypertension, dyslipidemia, smoking, alcohol consumption, and stroke further complicate the clinical picture. The review examines current diagnostic methods, including cognitive evaluations, neuroimaging techniques (magnetic resonance imaging, positron emission tomography, electroencephalography), and electrophysiological tools, pointing out their limitations in detecting early-stage cognitive decline. It suggests the potential for developing biomarkers, such as amyloid-beta and tau proteins, along with digital biomarkers, for the early identification of cognitive deterioration and for creating novel treatment approaches. It underscores the importance of understanding the interplay between metabolic and vascular dysfunctions, emphasizing the necessity for early detection and personalized therapies. This also identifies gaps in current research, such as the lack of standardized biomarkers and the need for longitudinal studies, stressing the importance of a collaborative effort to tackle these issues. This review emphasizes the development of novel diagnostic tools and personalized treatments, including pharmacological interventions, lifestyle modifications, and cognitive training. The study encourages further research to fill knowledge gaps and find effective solutions for this growing public health issue.
Key findings
- It suggests the potential for developing biomarkers, such as amyloid-beta and tau proteins, along with digital biomarkers, for the early identification of cognitive deterioration and for creating novel treatment approaches.
- It underscores the importance of understanding the interplay between metabolic and vascular dysfunctions, emphasizing the necessity for early detection and personalized therapies.
- This also identifies gaps in current research, such as the lack of standardized biomarkers and the need for longitudinal studies, stressing the importance of a collaborative effort to tackle these issues.
- This review emphasizes the development of novel diagnostic tools and personalized treatments, including pharmacological interventions, lifestyle modifications, and cognitive training.
- The study encourages further research to fill knowledge gaps and find effective solutions for this growing public health issue.
Why it matters
This review discusses how type 2 diabetes-related metabolic and blood vessel problems may contribute to cognitive decline and suggests possible biomarkers for early detection. It is a review and does not provide evidence that any treatment cures or prevents Alzheimer's disease.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 40/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Chronicle of Diabetes Research and Practice) |
| Journal's citation record | 0 / 4 | Chronicle of Diabetes Research and Practice: journal h-index 4 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Arbind Kumar Choudhary: h-index 11 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | All India Institute of Medical Sciences: institution h-index 440 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.4103/cdrp.cdrp_11_24
- Original source →
- Free full text: Chronicle of Diabetes Research and Practice →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Choudhary, A. K. (2025). Type 2 Diabetes and Cognitive Decline: A Neurovascular Perspective. Chronicle of Diabetes Research and Practice. https://doi.org/10.4103/cdrp.cdrp_11_24
Vancouver
Choudhary AK. Type 2 Diabetes and Cognitive Decline: A Neurovascular Perspective. Chronicle of Diabetes Research and Practice. 2025. doi:10.4103/cdrp.cdrp_11_24.
BibTeX
@article{choudhary2025-b4e51807,
author = {Choudhary, Arbind Kumar},
title = {{Type 2 Diabetes and Cognitive Decline: A Neurovascular Perspective}},
journal = {Chronicle of Diabetes Research and Practice},
year = {2025},
doi = {10.4103/cdrp.cdrp_11_24},
url = {https://doi.org/10.4103/cdrp.cdrp_11_24}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.