Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Non-heme iron, which is more abundant in plant-based sources, poses challenges about its lower bioavailability and this could contribute to an increased risk of anemia in these populations.
Why it matters
This review examines iron status in people following vegetarian and vegan diets, noting that well-planned plant-based diets can be nutritionally adequate. It contains no information on Alzheimer's disease.
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On the test set, MICE imputation yielded the highest accuracy for both RF (0.76) and LR (0.81), while SVM performed best with median imputation (0.81).
Why it matters
This study compared ways of filling in missing data and found that the choice of method significantly affects how accurately dementia is classified, with MICE generally performing best. It is a methods study and does not address treating, curing or preventing Alzheimer's disease.
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We identified key limitations in traditional assessment methods and classified SS symptoms into five domains: psychomotor symptoms, cognitive and perceptual disturbances, mood and affective symptoms, psychosis, and disruptions in activities of daily living and instrumental activities of daily living.
Why it matters
This scoping review proposes a multimodal platform integrating sensor technologies to enhance risk identification, diagnosis, continuous monitoring, and treatment of Sundown Syndrome. The platform is a proposed roadmap for future investigation, not an established treatment or cure.
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The growing prevalence of dementia emphasizes the need for effective prevention strategies.
Why it matters
This study examined whether genetic background affects how much people with mild cognitive impairment benefit from a multidomain intervention, and found no statistically significant differences in cognitive improvement for participants aged 75 or older. It does not show that the intervention prevents dementia, and the authors are still identifying who benefits most.
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Using raw data from the CFD and the GLMnet algorithm, we could accurately differentiate between DEM vs. HC with accuracies ranging up to 94.0%.
Why it matters
Machine learning combined with the Cognitive Functions Dementia test set differentiated dementia from healthy controls with accuracies up to 94.0%, and dementia from depression with accuracies up to 80.8%. The authors describe this as preliminary evidence that these algorithms could aid clinicians in differential diagnosis, not as a treatment or cure.
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The caregiver burden was found at a moderate to severe level with the average score of 58.14(12.84).
Why it matters
This cross-sectional study found that caregivers with a stronger sense of coherence reported lower caregiver burden, and that emotion-focused and dysfunctional coping strategies partly explained this link. It suggests that future support programs could focus on changing caregivers' coping behaviors, but it does not test whether such programs actually reduce burden.
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The training significantly improved caregivers' dementia knowledge and self-efficacy but did not reduce caregivers' distress and depression, nor decrease care recipients' emergency room visits and hospitalizations.
Why it matters
A multiweek online training improved home care workers' dementia knowledge and self-efficacy. However, it did not reduce caregivers' distress and depression or decrease care recipients' emergency room visits and hospitalizations.
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Among 177 403 decedents, 82.41% had cancer and 17.59% non-cancer diagnoses.
Why it matters
Among 177,403 decedents, non-cancer patients were more likely to start palliative care in the final days of life, though initiation became earlier over time for both groups. This is about timing of palliative care, not a treatment or cure for Alzheimer's disease.
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AI/AN patients at the end-of-life were more likely to be hospitalized and less likely to use hospice compared with their NHW counterparts.
Why it matters
This analysis found American Indian and Alaska Native patients at the end-of-life were more likely to be hospitalized and less likely to use hospice than their non-Hispanic White counterparts. Having dementia and cancer was associated with more hospice days for both groups.
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We identified two overarching themes. Firstly, there was a complex interaction of LTCs, sleep and dementia.
Why it matters
This qualitative study describes a complex interaction between long-term health conditions, sleep and dementia, and notes that carers were exhausted and faced dilemmas about giving pain relief. It highlights the need for adequate analgesia and support for family carers, not a treatment or cure for dementia.
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A total of 2056 papers related to machine learning in patients with MCI were retrieved from the Wo SCC database.
Why it matters
This bibliometric analysis of 2056 papers describes research trends in machine learning for mild cognitive impairment, including prediction, automated monitoring and personalized medicine as current hotspots. It maps the literature and does not test any treatment, cure or prevention.
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Stroke is a leading cause of death and disability globally, with significant long-term impacts such as post-stroke cognitive impairment (PSCI).
Why it matters
This review describes how stroke can lead to cognitive impairment and raises dementia risk, involving vascular damage, neurodegenerative changes and chronic inflammation. It summarizes possible mechanisms but does not report a treatment or cure.
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40/100
Falls before dementia were linked to a higher risk of dementia.
Why it matters
In this UK Biobank study of over 400,000 participants, people who experienced falls had higher risks of all-cause dementia, Alzheimer disease, vascular dementia, and non-Alzheimer/non-vascular dementia. Fall experiences had synergistic effects with dementia risk factors including the APOE ε4 allele, family history of dementia, and frailty.
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A total of 800 questionnaires were sent out in this survey, and 778 were effectively collected, with an effective recovery rate of 97.25%.
Why it matters
Among 778 elderly people in Huzhou City, the prevalence of mild cognitive impairment was 10.54%, and being female, older age, and higher scores on certain screening and depression questionnaires were risk factors. This is a prevalence and risk factor survey, not a treatment or cure.
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Twenty-two studies (RCTs, non-RCTs, single arm and prospective trials) were included (n = 6-977; mean age: 72.0 years; 66.9% male).
Why it matters
This scoping review found that clinical trials on hearing loss treatment and cognitive outcomes predominantly enrolled White participants, with underrepresentation of Black, Asian, and Hispanic/Latino populations. It highlights the need for more representative recruitment but does not test a treatment for Alzheimer's disease.
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Social networks shrank linearly as death approached.
Why it matters
Social networks shrank as death approached for White people with dementia, while Hispanic/Latino people with dementia gained close extended family members and Black networks were more stable. The authors suggest these network strengths could be used to develop care and support, but this does not test any treatment, cure, or prevention.
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LPA identified four intrinsic profiles: Profile 1 had low motivation; Profile 2 had high motivation and self-efficacy, but poor dementia knowledge; Profile 3 had moderate motivation; and Profile 4 had low motivation and high apathy.
Why it matters
This study grouped middle-aged adults into four profiles based on motivation, self-efficacy, apathy, and dementia knowledge, and found these groups differed in health behaviors and dementia risk. It suggests that different types of intervention strategies may be needed for dementia prevention, but it did not test whether any intervention actually prevents dementia.
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Nearly 7 million Americans are living with Alzheimer's disease or a related dementia (ADRD).
Why it matters
This review discusses the need for better quality measures for dementia care and the potential of payment models like the GUIDE Model to improve care delivery and address disparities. It does not test any treatment or prevention for Alzheimer's disease.
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The thematic analysis identified 12 themes: manifestations, sexual practices, impact, control, emotional formulations, beliefs in causes of hypersexuality and attributions, relationship with the partner, dealing with hypersexuality, coping with hypersexuality, self-image, stigma and professional help-seeking.
Why it matters
This qualitative study found that hypersexuality in Parkinson's disease and frontotemporal dementia causes distress and strain on carers' mental health and marital life, and that carers face barriers to seeking professional help. It suggests that healthcare professionals should recognise these psychological and relational consequences and that psychoeducation, support groups and tailored interventions are recommended to alleviate emotional distress.
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For the interim analysis as of October 2024, the results of the MCI study arm are reported (n=42).
Why it matters
In this preliminary interim analysis of 42 patients with mild cognitive impairment, those using the MEMODIO app showed significantly improved cognition compared to those receiving standard care alone. Quality of life, physical activity and daily living activities were not significantly different from baseline at this interim point.
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The drive for positive social interactions, or "social rewards", is an important motivator of human behaviour, conferring several adaptive benefits.
Why it matters
This paper proposes a framework suggesting that social rewards become devalued in frontotemporal dementia, leading to social withdrawal, while social rewards hold equivalent or increased value in older adulthood. It is a theoretical framework, not a treatment trial, so it does not show any cure or prevention.
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40/100
During a median follow-up of 12.8 years, 2219 incident dementias were recorded.
Why it matters
In UK Biobank participants followed a median of 12.8 years, tinnitus was associated with a 10% higher risk of dementia, with higher risk for more severe tinnitus, and noise exposure over 5 years was associated with a 12% higher risk. These observational findings point to tinnitus and noise as public health targets for prevention but do not show that treating them prevents dementia.
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Probable sarcopenia subjects with dementia were older (68.5(7.8) years old) as compared to those without dementia (66.0(6.0) years old).
Why it matters
Among older adults with probable sarcopenia or sarcopenia, hypertension was the only factor associated with dementia risk after adjusting for confounders. The authors suggest good blood pressure control may lower dementia risk in these patients, but they call for clinical trials to confirm this.
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BackgroundStructural changes in medial temporal lobes including the fusiform gyrus, a critical area in face recognition, precede the progression of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD).
Why it matters
This small EEG study found that people with amnestic mild cognitive impairment lacked the face inversion effect in P1 amplitude and the right hemisphere advantage in N170 for faces compared with healthy controls. It is early-stage and does not test treatment or cure, but it suggests face-processing brain signals may be altered in this group.
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Within the 440 included surveys, respondents particularly over-estimated frailty prevalence in older hospitalised patients, with two-thirds choosing between 41 and 80% prevalence, when the literature suggests only 23-46%, but paradoxically underestimated the frequency of frailty in people with delirium (more than three quarters of responses across 21-80%; literature suggests 71-93%).
Why it matters
This survey of European geriatricians found varied and sometimes inaccurate perceptions about the prevalence and links between dementia, delirium and frailty. It does not test any treatment or prevention for Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Determinants of disease and disability in the elderly: The Rotterdam elderly study
- Generative artificial intelligence in dementia care: a scoping review protocol on nursing roles, experiences and ethical perspectives
- Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
- Clinical features of frontal lobe dementia in comparison to Alzheimer's disease
- Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank
- Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study
- Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review
- Assessing Palliative Care Content in Dementia Care Guidelines: A Systematic Review
- A Nurse‐Initiated Protocol for Interprofessional Management of Changed Behaviours in Hospital Patients With Dementia and/or Delirium: A Modified e‐Delphi Study
- Preventing Burdensome Transitions of Nursing Home Residents with Advanced Dementia: It's More than Advance Directives